Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion

Amir Monemian Esfahani, Jordan Rosenbohm, Keerthana Reddy, Xiaowei Jin, Tasneem Bouzid, Brandon Riehl, Eunju Kim, Jung Yul Lim, Ruiguo Yang

Research output: Contribution to journalArticle

Abstract

Cell-cell adhesion complexes are macromolecular adhesive organelles that integrate cells into tissues. This mechanochemical coupling in cell-cell adhesion is required for a large number of cell behaviors, and perturbations of the cell-cell adhesion structure or related mechanotransduction pathways can lead to critical pathological conditions such as skin and heart diseases, arthritis, and cancer. Mechanical stretching has been a widely used method to stimulate the mechanotransduction process originating from the cell-cell adhesion and cell-extracellular matrix (ECM) complexes. These studies aimed to reveal the biophysical processes governing cell proliferation, wound healing, gene expression regulation, and cell differentiation in various tissues, including cardiac, muscle, vascular, and bone. This review explores techniques in mechanical stretching in two-dimensional settings with different stretching regimens on different cell types. The mechanotransduction responses from these different cell types will be discussed with an emphasis on their biophysical transformations during mechanical stretching and the cross talk between the cell-cell and cell-ECM adhesion complexes. Therapeutic aspects of mechanical stretching are reviewed considering these cellular responses after the application of mechanical forces, with a focus on wound healing and tissue regeneration. Mechanical stretching has been proposed as a therapeutic option for tissue regeneration and wound healing. It has been accepted that mechanotransduction processes elicited by mechanical stretching govern cellular response and behavior, and these studies have predominantly focused on the cell-extracellular matrix (ECM) sites. This review serves the mechanobiology community by shifting the focus of mechanical stretching effects from cell-ECM adhesions to the less examined cell-cell adhesions, which we believe play an equally important role in orchestrating the response pathways.

Original languageEnglish (US)
Pages (from-to)631-640
Number of pages10
JournalTissue Engineering - Part C: Methods
Volume25
Issue number11
DOIs
StatePublished - Nov 2019

Fingerprint

Tissue regeneration
Cell adhesion
Cell Adhesion
Stretching
Regeneration
Extracellular Matrix
Cell-Matrix Junctions
Wound Healing
Gene expression regulation
Adhesion
Tissue
Macromolecular Substances
Biophysical Phenomena
Cell proliferation
Mechanical Phenomena
Biophysics
Muscle
Adhesives
Skin
Bone

Keywords

  • cell-cell adhesion
  • mechanical stretching
  • mechanotransduction
  • regenerative medicine
  • tissue regeneration
  • wound healing

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Monemian Esfahani, A., Rosenbohm, J., Reddy, K., Jin, X., Bouzid, T., Riehl, B., ... Yang, R. (2019). Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion. Tissue Engineering - Part C: Methods, 25(11), 631-640. https://doi.org/10.1089/ten.tec.2019.0098

Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion. / Monemian Esfahani, Amir; Rosenbohm, Jordan; Reddy, Keerthana; Jin, Xiaowei; Bouzid, Tasneem; Riehl, Brandon; Kim, Eunju; Lim, Jung Yul; Yang, Ruiguo.

In: Tissue Engineering - Part C: Methods, Vol. 25, No. 11, 11.2019, p. 631-640.

Research output: Contribution to journalArticle

Monemian Esfahani, A, Rosenbohm, J, Reddy, K, Jin, X, Bouzid, T, Riehl, B, Kim, E, Lim, JY & Yang, R 2019, 'Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion', Tissue Engineering - Part C: Methods, vol. 25, no. 11, pp. 631-640. https://doi.org/10.1089/ten.tec.2019.0098
Monemian Esfahani A, Rosenbohm J, Reddy K, Jin X, Bouzid T, Riehl B et al. Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion. Tissue Engineering - Part C: Methods. 2019 Nov;25(11):631-640. https://doi.org/10.1089/ten.tec.2019.0098
Monemian Esfahani, Amir ; Rosenbohm, Jordan ; Reddy, Keerthana ; Jin, Xiaowei ; Bouzid, Tasneem ; Riehl, Brandon ; Kim, Eunju ; Lim, Jung Yul ; Yang, Ruiguo. / Tissue Regeneration from Mechanical Stretching of Cell-Cell Adhesion. In: Tissue Engineering - Part C: Methods. 2019 ; Vol. 25, No. 11. pp. 631-640.
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