Tissue invasion and metastasis: Molecular, biological and clinical perspectives

W. G. Jiang, A. J. Sanders, M. Katoh, H. Ungefroren, F. Gieseler, M. Prince, S. K. Thompson, M. Zollo, D. Spano, P. Dhawan, D. Sliva, P. R. Subbarayan, M. Sarkar, K. Honoki, H. Fujii, A. G. Georgakilas, A. Amedei, E. Niccolai, A. Amin, S. S. AshrafL. Ye, W. G. Helferich, X. Yang, C. S. Boosani, G. Guha, M. R. Ciriolo, K. Aquilano, S. Chen, A. S. Azmi, W. N. Keith, A. Bilsland, D. Bhakta, D. Halicka, S. Nowsheen, F. Pantano, D. Santini

Research output: Contribution to journalReview article

163 Citations (Scopus)

Abstract

Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast percentage of cancer patient mortality. While advances in this area have been made, the process of cancer metastasis and the factors governing cancer spread and establishment at secondary locations is still poorly understood. The current article summarizes recent progress in this area of research, both in the understanding of the underlying biological processes and in the therapeutic strategies for the management of metastasis. This review lists the disruption of E-cadherin and tight junctions, key signaling pathways, including urokinase type plasminogen activator (uPA), phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene (PI3K/AKT), focal adhesion kinase (FAK), β-catenin/zinc finger E-box binding homeobox 1 (ZEB-1) and transforming growth factor beta (TGF-β), together with inactivation of activator protein-1 (AP-1) and suppression of matrix metalloproteinase-9 (MMP-9) activity as key targets and the use of phytochemicals, or natural products, such as those from Agaricus blazei, Albatrellus confluens, Cordyceps militaris, Ganoderma lucidum, Poria cocos and Silybum marianum, together with diet derived fatty acids gamma linolenic acid (GLA) and eicosapentanoic acid (EPA) and inhibitory compounds as useful approaches to target tissue invasion and metastasis as well as other hallmark areas of cancer. Together, these strategies could represent new, inexpensive, low toxicity strategies to aid in the management of cancer metastasis as well as having holistic effects against other cancer hallmarks.

Original languageEnglish (US)
Pages (from-to)S244-S275
JournalSeminars in Cancer Biology
Volume35
DOIs
StatePublished - Dec 1 2015

Fingerprint

Neoplasm Metastasis
Neoplasms
Milk Thistle
Cordyceps
Reishi
Phosphatidylinositol 3-Kinase
gamma-Linolenic Acid
Agaricus
Biological Phenomena
Catenins
Focal Adhesion Protein-Tyrosine Kinases
Eicosapentaenoic Acid
Thymoma
Mortality
Tight Junctions
Matrix Metalloproteinase 9
Transcription Factor AP-1
Urokinase-Type Plasminogen Activator
Phytochemicals
Cadherins

Keywords

  • Cancer metastasis
  • Cancer therapy
  • Invasion

ASJC Scopus subject areas

  • Cancer Research

Cite this

Jiang, W. G., Sanders, A. J., Katoh, M., Ungefroren, H., Gieseler, F., Prince, M., ... Santini, D. (2015). Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Seminars in Cancer Biology, 35, S244-S275. https://doi.org/10.1016/j.semcancer.2015.03.008

Tissue invasion and metastasis : Molecular, biological and clinical perspectives. / Jiang, W. G.; Sanders, A. J.; Katoh, M.; Ungefroren, H.; Gieseler, F.; Prince, M.; Thompson, S. K.; Zollo, M.; Spano, D.; Dhawan, P.; Sliva, D.; Subbarayan, P. R.; Sarkar, M.; Honoki, K.; Fujii, H.; Georgakilas, A. G.; Amedei, A.; Niccolai, E.; Amin, A.; Ashraf, S. S.; Ye, L.; Helferich, W. G.; Yang, X.; Boosani, C. S.; Guha, G.; Ciriolo, M. R.; Aquilano, K.; Chen, S.; Azmi, A. S.; Keith, W. N.; Bilsland, A.; Bhakta, D.; Halicka, D.; Nowsheen, S.; Pantano, F.; Santini, D.

In: Seminars in Cancer Biology, Vol. 35, 01.12.2015, p. S244-S275.

Research output: Contribution to journalReview article

Jiang, WG, Sanders, AJ, Katoh, M, Ungefroren, H, Gieseler, F, Prince, M, Thompson, SK, Zollo, M, Spano, D, Dhawan, P, Sliva, D, Subbarayan, PR, Sarkar, M, Honoki, K, Fujii, H, Georgakilas, AG, Amedei, A, Niccolai, E, Amin, A, Ashraf, SS, Ye, L, Helferich, WG, Yang, X, Boosani, CS, Guha, G, Ciriolo, MR, Aquilano, K, Chen, S, Azmi, AS, Keith, WN, Bilsland, A, Bhakta, D, Halicka, D, Nowsheen, S, Pantano, F & Santini, D 2015, 'Tissue invasion and metastasis: Molecular, biological and clinical perspectives', Seminars in Cancer Biology, vol. 35, pp. S244-S275. https://doi.org/10.1016/j.semcancer.2015.03.008
Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M et al. Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Seminars in Cancer Biology. 2015 Dec 1;35:S244-S275. https://doi.org/10.1016/j.semcancer.2015.03.008
Jiang, W. G. ; Sanders, A. J. ; Katoh, M. ; Ungefroren, H. ; Gieseler, F. ; Prince, M. ; Thompson, S. K. ; Zollo, M. ; Spano, D. ; Dhawan, P. ; Sliva, D. ; Subbarayan, P. R. ; Sarkar, M. ; Honoki, K. ; Fujii, H. ; Georgakilas, A. G. ; Amedei, A. ; Niccolai, E. ; Amin, A. ; Ashraf, S. S. ; Ye, L. ; Helferich, W. G. ; Yang, X. ; Boosani, C. S. ; Guha, G. ; Ciriolo, M. R. ; Aquilano, K. ; Chen, S. ; Azmi, A. S. ; Keith, W. N. ; Bilsland, A. ; Bhakta, D. ; Halicka, D. ; Nowsheen, S. ; Pantano, F. ; Santini, D. / Tissue invasion and metastasis : Molecular, biological and clinical perspectives. In: Seminars in Cancer Biology. 2015 ; Vol. 35. pp. S244-S275.
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