Tissue factor gene localized to human chromosome 1 (1pter→1p21)

Steven D Carson, W. Michael Henry, Thomas B. Shows

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Tissue factor (tissue thromboplastin, coagulation factor III), a protein component of cell membranes, is an essential cofactor for factor VII-dependent initiation of blood coagulation. Since no tissue factor-deficient condition has been described, it is one of only a few proteins of the coagulation system for which the pattern of inheritance has not been ascertained. Because of the species-specificity of tissue factor activity and the availability of a very sensitive chromogenic assay, it was possible in the present study to use somatic cell hybrids to assign the chromosomal location of the tissue factor structural gene (F3) to human chromosome 1 (1pter→1p21).

Original languageEnglish (US)
Pages (from-to)991-993
Number of pages3
JournalScience
Volume229
Issue number4717
DOIs
StatePublished - Jan 1 1985

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Chromosomes, Human, Pair 1
Human Chromosomes
Thromboplastin
Genes
Species Specificity
Inheritance Patterns
Factor VII
Hybrid Cells
Blood Coagulation
Membrane Proteins
Proteins

ASJC Scopus subject areas

  • General

Cite this

Tissue factor gene localized to human chromosome 1 (1pter→1p21). / Carson, Steven D; Henry, W. Michael; Shows, Thomas B.

In: Science, Vol. 229, No. 4717, 01.01.1985, p. 991-993.

Research output: Contribution to journalArticle

Carson, Steven D ; Henry, W. Michael ; Shows, Thomas B. / Tissue factor gene localized to human chromosome 1 (1pter→1p21). In: Science. 1985 ; Vol. 229, No. 4717. pp. 991-993.
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