Tissue factor antigen in senile plaques of Alzheimer's disease

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Tissue factor (tissue thromboplastin) is the primary initiator of the extrinsic coagulation pathway, triggering a proteolytic cascade when exposed to circulating coagulation factors. In this study, the distribution of tissue factor was examined immunohistochemically in Alzheimer's disease (AD) and control brains. Tissue factor was expressed diffusely in the neocortex, but in AD there was enhanced immunoreactivity in senile plaques. Although tissue factor might potentially contribute to the formation of senile plaques, it could also accumulate in the plaques as a secondary response to other biochemical perturbations.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalAmerican Journal of Pathology
Volume139
Issue number3
StatePublished - Sep 1 1991

Fingerprint

Amyloid Plaques
Thromboplastin
Alzheimer Disease
Antigens
Blood Coagulation Factors
Neocortex
Brain

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tissue factor antigen in senile plaques of Alzheimer's disease. / McComb, Rodney D; Miller, Keith A.; Carson, Steven D.

In: American Journal of Pathology, Vol. 139, No. 3, 01.09.1991, p. 491-494.

Research output: Contribution to journalArticle

@article{f8a271bf304e45cd964f656ab842c374,
title = "Tissue factor antigen in senile plaques of Alzheimer's disease",
abstract = "Tissue factor (tissue thromboplastin) is the primary initiator of the extrinsic coagulation pathway, triggering a proteolytic cascade when exposed to circulating coagulation factors. In this study, the distribution of tissue factor was examined immunohistochemically in Alzheimer's disease (AD) and control brains. Tissue factor was expressed diffusely in the neocortex, but in AD there was enhanced immunoreactivity in senile plaques. Although tissue factor might potentially contribute to the formation of senile plaques, it could also accumulate in the plaques as a secondary response to other biochemical perturbations.",
author = "McComb, {Rodney D} and Miller, {Keith A.} and Carson, {Steven D}",
year = "1991",
month = "9",
day = "1",
language = "English (US)",
volume = "139",
pages = "491--494",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Tissue factor antigen in senile plaques of Alzheimer's disease

AU - McComb, Rodney D

AU - Miller, Keith A.

AU - Carson, Steven D

PY - 1991/9/1

Y1 - 1991/9/1

N2 - Tissue factor (tissue thromboplastin) is the primary initiator of the extrinsic coagulation pathway, triggering a proteolytic cascade when exposed to circulating coagulation factors. In this study, the distribution of tissue factor was examined immunohistochemically in Alzheimer's disease (AD) and control brains. Tissue factor was expressed diffusely in the neocortex, but in AD there was enhanced immunoreactivity in senile plaques. Although tissue factor might potentially contribute to the formation of senile plaques, it could also accumulate in the plaques as a secondary response to other biochemical perturbations.

AB - Tissue factor (tissue thromboplastin) is the primary initiator of the extrinsic coagulation pathway, triggering a proteolytic cascade when exposed to circulating coagulation factors. In this study, the distribution of tissue factor was examined immunohistochemically in Alzheimer's disease (AD) and control brains. Tissue factor was expressed diffusely in the neocortex, but in AD there was enhanced immunoreactivity in senile plaques. Although tissue factor might potentially contribute to the formation of senile plaques, it could also accumulate in the plaques as a secondary response to other biochemical perturbations.

UR - http://www.scopus.com/inward/record.url?scp=0025896355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025896355&partnerID=8YFLogxK

M3 - Article

C2 - 1887858

AN - SCOPUS:0025896355

VL - 139

SP - 491

EP - 494

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 3

ER -