Time-dependent reduction of glutamate current in retinal bipolar cells

Scott A Nawy, Craig E. Jahr

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Glutamate hyperpolarizes retinal depolarizing bipolar cells (DBCs) by decreasing a non-specific cation conductance. We have investigated this action of glutamate using whole-cell voltage clamp of DBCs in larval tiger salamander retinal slices and here report two observations: a wash-out of the glutamate response and a concomitant decrease in resting membrane conductance. The wash-out may be due to the loss of a second messenger-mediated mechanism linking the receptor to the response. The decrease in resting membrane conductance suggests that this second messenger may be required to maintain DBC glutamate channels in an open state in the absence of the receptor ligand.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalNeuroscience Letters
Volume108
Issue number3
DOIs
StatePublished - Jan 22 1990

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Retinal Bipolar Cells
Glutamic Acid
Second Messenger Systems
Ambystoma
Membranes
Cations
Ligands

Keywords

  • 2-Amino-4-phosphonobutyrate receptor
  • Bipolar cell
  • Glutamate
  • Retinal slice
  • Second messenger
  • Wash-out

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Time-dependent reduction of glutamate current in retinal bipolar cells. / Nawy, Scott A; Jahr, Craig E.

In: Neuroscience Letters, Vol. 108, No. 3, 22.01.1990, p. 279-283.

Research output: Contribution to journalArticle

Nawy, Scott A ; Jahr, Craig E. / Time-dependent reduction of glutamate current in retinal bipolar cells. In: Neuroscience Letters. 1990 ; Vol. 108, No. 3. pp. 279-283.
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