Time course of ADC(w) changes in ischemic stroke: Beyond the human eye!

V. Nagesh, K. M.A. Welch, J. P. Windham, S. Patel, S. R. Levine, D. Hearshen, D. Peck, K. Robbins, L. D'Olhaberriague, H. Soltanian-Zadeh, M. D. Boska

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background and Purpose - Using newly developed computerized image analysis, we studied the heterogeneity of apparent diffusion coefficient of water (ADC(w)) values in human ischemic stroke within 10 hours of onset. Methods - Echo-planar trace diffusion-weighted images from 9 patients with focal cortical ischemic stroke were obtained within 10 hours of symptom onset. An Iterative Self-Organizing Data Analysis (ISODATA) clustering algorithm was implemented to segment different tissue types with a series of DW images. ADC(w) maps were calculated from 4 DW images on a pixel-by-pixel basis. The segmented zones within the lesion were characterized as low, pseudonormal, or high, expressed as a ratio of the mean±SD of ADC(w) of contralateral noninvolved tissue. Results - The average ADC(w) in the ischemic stroke region within 10 hours of onset was significantly depressed compared with homologous contralateral tissue (626.6±76.8 versus 842.9±60.4x10-6 mm2/s; P < 0.0001). Nevertheless, ISODATA segmentation yielded multiple zones within the stroke region that were characterized as low, pseudonormal, and high. The mean proportion of low:pseudonormal:high was 72%:20%:8%. Conclusions - Despite low average ADC(w), computer-assisted segmentation of DW MRI detected heterogeneous zones within ischemic lesions corresponding to low, pseudonormal, and high ADC(w) not visible to the human eye. This supports acute elevation of ADC(w) in human ischemic stroke and, accordingly, different temporal rates of tissue evolution toward infarction.

Original languageEnglish (US)
Pages (from-to)1778-1782
Number of pages5
JournalStroke
Volume29
Issue number9
DOIs
StatePublished - Sep 1998

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Stroke
Water
Infarction
Cluster Analysis

Keywords

  • Cerebral ischemia, focal
  • Magnetic resonance imaging
  • Signal processing, computer assisted
  • Stroke, acute

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Nagesh, V., Welch, K. M. A., Windham, J. P., Patel, S., Levine, S. R., Hearshen, D., ... Boska, M. D. (1998). Time course of ADC(w) changes in ischemic stroke: Beyond the human eye! Stroke, 29(9), 1778-1782. https://doi.org/10.1161/01.STR.29.9.1778

Time course of ADC(w) changes in ischemic stroke : Beyond the human eye! / Nagesh, V.; Welch, K. M.A.; Windham, J. P.; Patel, S.; Levine, S. R.; Hearshen, D.; Peck, D.; Robbins, K.; D'Olhaberriague, L.; Soltanian-Zadeh, H.; Boska, M. D.

In: Stroke, Vol. 29, No. 9, 09.1998, p. 1778-1782.

Research output: Contribution to journalArticle

Nagesh, V, Welch, KMA, Windham, JP, Patel, S, Levine, SR, Hearshen, D, Peck, D, Robbins, K, D'Olhaberriague, L, Soltanian-Zadeh, H & Boska, MD 1998, 'Time course of ADC(w) changes in ischemic stroke: Beyond the human eye!', Stroke, vol. 29, no. 9, pp. 1778-1782. https://doi.org/10.1161/01.STR.29.9.1778
Nagesh V, Welch KMA, Windham JP, Patel S, Levine SR, Hearshen D et al. Time course of ADC(w) changes in ischemic stroke: Beyond the human eye! Stroke. 1998 Sep;29(9):1778-1782. https://doi.org/10.1161/01.STR.29.9.1778
Nagesh, V. ; Welch, K. M.A. ; Windham, J. P. ; Patel, S. ; Levine, S. R. ; Hearshen, D. ; Peck, D. ; Robbins, K. ; D'Olhaberriague, L. ; Soltanian-Zadeh, H. ; Boska, M. D. / Time course of ADC(w) changes in ischemic stroke : Beyond the human eye!. In: Stroke. 1998 ; Vol. 29, No. 9. pp. 1778-1782.
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title = "Time course of ADC(w) changes in ischemic stroke: Beyond the human eye!",
abstract = "Background and Purpose - Using newly developed computerized image analysis, we studied the heterogeneity of apparent diffusion coefficient of water (ADC(w)) values in human ischemic stroke within 10 hours of onset. Methods - Echo-planar trace diffusion-weighted images from 9 patients with focal cortical ischemic stroke were obtained within 10 hours of symptom onset. An Iterative Self-Organizing Data Analysis (ISODATA) clustering algorithm was implemented to segment different tissue types with a series of DW images. ADC(w) maps were calculated from 4 DW images on a pixel-by-pixel basis. The segmented zones within the lesion were characterized as low, pseudonormal, or high, expressed as a ratio of the mean±SD of ADC(w) of contralateral noninvolved tissue. Results - The average ADC(w) in the ischemic stroke region within 10 hours of onset was significantly depressed compared with homologous contralateral tissue (626.6±76.8 versus 842.9±60.4x10-6 mm2/s; P < 0.0001). Nevertheless, ISODATA segmentation yielded multiple zones within the stroke region that were characterized as low, pseudonormal, and high. The mean proportion of low:pseudonormal:high was 72{\%}:20{\%}:8{\%}. Conclusions - Despite low average ADC(w), computer-assisted segmentation of DW MRI detected heterogeneous zones within ischemic lesions corresponding to low, pseudonormal, and high ADC(w) not visible to the human eye. This supports acute elevation of ADC(w) in human ischemic stroke and, accordingly, different temporal rates of tissue evolution toward infarction.",
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T2 - Beyond the human eye!

AU - Nagesh, V.

AU - Welch, K. M.A.

AU - Windham, J. P.

AU - Patel, S.

AU - Levine, S. R.

AU - Hearshen, D.

AU - Peck, D.

AU - Robbins, K.

AU - D'Olhaberriague, L.

AU - Soltanian-Zadeh, H.

AU - Boska, M. D.

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N2 - Background and Purpose - Using newly developed computerized image analysis, we studied the heterogeneity of apparent diffusion coefficient of water (ADC(w)) values in human ischemic stroke within 10 hours of onset. Methods - Echo-planar trace diffusion-weighted images from 9 patients with focal cortical ischemic stroke were obtained within 10 hours of symptom onset. An Iterative Self-Organizing Data Analysis (ISODATA) clustering algorithm was implemented to segment different tissue types with a series of DW images. ADC(w) maps were calculated from 4 DW images on a pixel-by-pixel basis. The segmented zones within the lesion were characterized as low, pseudonormal, or high, expressed as a ratio of the mean±SD of ADC(w) of contralateral noninvolved tissue. Results - The average ADC(w) in the ischemic stroke region within 10 hours of onset was significantly depressed compared with homologous contralateral tissue (626.6±76.8 versus 842.9±60.4x10-6 mm2/s; P < 0.0001). Nevertheless, ISODATA segmentation yielded multiple zones within the stroke region that were characterized as low, pseudonormal, and high. The mean proportion of low:pseudonormal:high was 72%:20%:8%. Conclusions - Despite low average ADC(w), computer-assisted segmentation of DW MRI detected heterogeneous zones within ischemic lesions corresponding to low, pseudonormal, and high ADC(w) not visible to the human eye. This supports acute elevation of ADC(w) in human ischemic stroke and, accordingly, different temporal rates of tissue evolution toward infarction.

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