Thyroid dependent maturation of β-adrenergic receptors in the rat lung

Jeffrey A. Whitsett, C. Darovec-Beckerman, Karen Adams, Jennifer Pollinger, Howard Needelman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

β-Adrenergic receptors were identified in membranes of fetal and postnatal rat lung with (-)-[ 3 H]dihydroalprenolol, [ 3 H]DHA. β-Receptor number (Bmax) increased 11-fold from day 18 of gestation to adult levels by day 28 of postnatal life. The increase of β-adrenergic receptors occurring between postnatal days 15 and 28 was dependent on thyroxine (T4) in propylthiouracil treated pups. β-Adrenergic receptors on day 28 were identical in euthyroid (PTU + T4) as compared to normal control pups (489±31 and 491±30 femtomoles·mg -1 ) however receptors were markedly reduced in 28 day hypothyroid pups (PTU alone), Bmax = 294±21.5, m±S.E. p<0.01. Treatment of the hypothyroid pups with T4 for three days on postnatal day 25 increased β-adrenergic receptors approximately two-fold by day 28. This thyroid hormone dependent increase in lung β-adrenergic receptors occurs between postnatal days 15 and 28 coincident with the known increase in thyroid gland activity in the rat pup.

Original languageEnglish (US)
Pages (from-to)913-917
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume97
Issue number3
DOIs
StatePublished - Dec 16 1980

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Adrenergic Receptors
Rats
Thyroid Gland
Lung
Dihydroalprenolol
Extraembryonic Membranes
Propylthiouracil
Thyroxine
Thyroid Hormones
Membranes
Pregnancy

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Thyroid dependent maturation of β-adrenergic receptors in the rat lung. / Whitsett, Jeffrey A.; Darovec-Beckerman, C.; Adams, Karen; Pollinger, Jennifer; Needelman, Howard.

In: Biochemical and Biophysical Research Communications, Vol. 97, No. 3, 16.12.1980, p. 913-917.

Research output: Contribution to journalArticle

Whitsett, Jeffrey A. ; Darovec-Beckerman, C. ; Adams, Karen ; Pollinger, Jennifer ; Needelman, Howard. / Thyroid dependent maturation of β-adrenergic receptors in the rat lung. In: Biochemical and Biophysical Research Communications. 1980 ; Vol. 97, No. 3. pp. 913-917.
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