Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia

John R. Priest, Norma K.C. Ramsay, Richard E. Latchaw, Lawrence A. Lockman, Duane K. Hasegawa, Thomas D. Coates, Peter Felix Coccia, J. Roger Edson, Mark E. Nesbit, William Krivit

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Sudden cerebrovascular insults occurred during or immediately following remission induction therapy in 4 children with acute lymphoblastic leukemia. In 3, cerebral infarction was due to thrombosis. In the fourth, an intracerebral hematoma developed representing either frank hemorrhaging or a hemorrhagic infarction. None of the patients had central nervous system leukemia or extreme leukocytosis at the time of diagnosis. Symptoms were obtundation, hemiparesis, seizures, and headache. The induction chemotherapy included L‐asparaginase which causes deficiencies of antithrombin, plasminogen, fibrinogen, and factors IX and XI. These hemostatic abnormalities may explain the thromboses and bleeding observed in these children.

Original languageEnglish (US)
Pages (from-to)1548-1554
Number of pages7
JournalCancer
Volume46
Issue number7
DOIs
StatePublished - Jan 1 1980

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Secondary Prevention
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thrombosis
Stroke
Factor XI
Remission Induction
Induction Chemotherapy
Factor IX
Antithrombins
Plasminogen
Leukocytosis
Cerebral Infarction
Paresis
Hemostatics
Hematoma
Fibrinogen
Infarction
Headache
Leukemia
Seizures

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Priest, J. R., Ramsay, N. K. C., Latchaw, R. E., Lockman, L. A., Hasegawa, D. K., Coates, T. D., ... Krivit, W. (1980). Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. Cancer, 46(7), 1548-1554. https://doi.org/10.1002/1097-0142(19801001)46:7<1548::AID-CNCR2820460709>3.0.CO;2-7

Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. / Priest, John R.; Ramsay, Norma K.C.; Latchaw, Richard E.; Lockman, Lawrence A.; Hasegawa, Duane K.; Coates, Thomas D.; Coccia, Peter Felix; Edson, J. Roger; Nesbit, Mark E.; Krivit, William.

In: Cancer, Vol. 46, No. 7, 01.01.1980, p. 1548-1554.

Research output: Contribution to journalArticle

Priest, JR, Ramsay, NKC, Latchaw, RE, Lockman, LA, Hasegawa, DK, Coates, TD, Coccia, PF, Edson, JR, Nesbit, ME & Krivit, W 1980, 'Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia', Cancer, vol. 46, no. 7, pp. 1548-1554. https://doi.org/10.1002/1097-0142(19801001)46:7<1548::AID-CNCR2820460709>3.0.CO;2-7
Priest, John R. ; Ramsay, Norma K.C. ; Latchaw, Richard E. ; Lockman, Lawrence A. ; Hasegawa, Duane K. ; Coates, Thomas D. ; Coccia, Peter Felix ; Edson, J. Roger ; Nesbit, Mark E. ; Krivit, William. / Thrombotic and hemorrhagic strokes complicating early therapy for childhood acute lymphoblastic leukemia. In: Cancer. 1980 ; Vol. 46, No. 7. pp. 1548-1554.
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