Therapeutic ultrasound for gene delivery

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

In vitro and in vivo studies using perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles to enhance gene delivery are reviewed. In vitro studies show PESDA binds to oligonucleotides and that ultrasound can be used to deposit these nucleotides. In addition, in vitro studies show that drug release from microspheres is dependent on ultrasound transmission frequency as well as pulsed or continuous application. Early in vivo studies confirm that ultrasound in combination with microbubbles can be used to facilitate gene deposition. However, the role of ultrasound targeting gene delivery remains to be determined.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalEchocardiography
Volume18
Issue number4
DOIs
StatePublished - Jan 1 2001

Fingerprint

Fluorocarbons
Microbubbles
Albumins
Genes
Glucose
Gene Targeting
Microspheres
Oligonucleotides
Therapeutics
Nucleotides
In Vitro Techniques
Drug Liberation

Keywords

  • Gene therapy
  • Microbubbles
  • Oligonucleotides
  • PESDA
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Therapeutic ultrasound for gene delivery. / Porter, Thomas Richard; Xie, Feng.

In: Echocardiography, Vol. 18, No. 4, 01.01.2001, p. 349-353.

Research output: Contribution to journalArticle

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