Abstract
In vitro and in vivo studies using perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles to enhance gene delivery are reviewed. In vitro studies show PESDA binds to oligonucleotides and that ultrasound can be used to deposit these nucleotides. In addition, in vitro studies show that drug release from microspheres is dependent on ultrasound transmission frequency as well as pulsed or continuous application. Early in vivo studies confirm that ultrasound in combination with microbubbles can be used to facilitate gene deposition. However, the role of ultrasound targeting gene delivery remains to be determined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 349-353 |
| Number of pages | 5 |
| Journal | Echocardiography |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2001 |
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Keywords
- Gene therapy
- Microbubbles
- Oligonucleotides
- PESDA
- Ultrasound
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
Therapeutic ultrasound for gene delivery. / Porter, Thomas Richard; Xie, Feng.
In: Echocardiography, Vol. 18, No. 4, 01.01.2001, p. 349-353.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Therapeutic ultrasound for gene delivery
AU - Porter, Thomas Richard
AU - Xie, Feng
PY - 2001/1/1
Y1 - 2001/1/1
N2 - In vitro and in vivo studies using perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles to enhance gene delivery are reviewed. In vitro studies show PESDA binds to oligonucleotides and that ultrasound can be used to deposit these nucleotides. In addition, in vitro studies show that drug release from microspheres is dependent on ultrasound transmission frequency as well as pulsed or continuous application. Early in vivo studies confirm that ultrasound in combination with microbubbles can be used to facilitate gene deposition. However, the role of ultrasound targeting gene delivery remains to be determined.
AB - In vitro and in vivo studies using perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles to enhance gene delivery are reviewed. In vitro studies show PESDA binds to oligonucleotides and that ultrasound can be used to deposit these nucleotides. In addition, in vitro studies show that drug release from microspheres is dependent on ultrasound transmission frequency as well as pulsed or continuous application. Early in vivo studies confirm that ultrasound in combination with microbubbles can be used to facilitate gene deposition. However, the role of ultrasound targeting gene delivery remains to be determined.
KW - Gene therapy
KW - Microbubbles
KW - Oligonucleotides
KW - PESDA
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=0034949891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034949891&partnerID=8YFLogxK
U2 - 10.1046/j.1540-8175.2001.00349.x
DO - 10.1046/j.1540-8175.2001.00349.x
M3 - Article
C2 - 11415508
AN - SCOPUS:0034949891
VL - 18
SP - 349
EP - 353
JO - Echocardiography
JF - Echocardiography
SN - 0742-2822
IS - 4
ER -