Therapeutic manipulation of the insulin receptor kinase - A review

Robert E Lewis, O. V. Chaika

Research output: Contribution to journalReview article

Abstract

Understanding the detailed mechanisms mediating insulin signal transduction has been viewed as a critical step in the development of therapeutic applications to ameliorate diabetes and its attendant complications. One critical element in the insulin-signalling pathway is the insulin receptor. The insulin receptor is a heterotetrameric transmembrane protein that binds insulin on the surface of cells and transduces insulin signals through the plasma membrane to the cytoplasm. With the cloning of the gene for the insulin receptor it became possible to efficiently manipulate the receptor and identify sequences that are crucial to its function. In turn, these analyses have uncovered potential therapeutic approaches to enhance receptor function. The patents covered by this review date from 1988 to 1999.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalExpert Opinion on Therapeutic Patents
Volume10
Issue number2
DOIs
StatePublished - Jan 1 2000

Fingerprint

Insulin Receptor
manipulation
Phosphotransferases
Insulin
patent
chronic illness
Patents
Therapeutics
Organism Cloning
Signal Transduction
Cytoplasm
Cell Membrane
Genes
Proteins

Keywords

  • Inhibitors
  • Insulin receptor
  • Insulin receptor kinase
  • Insulin signalling
  • Phosphorylation
  • Protein tyrosine phosphatase
  • Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Therapeutic manipulation of the insulin receptor kinase - A review. / Lewis, Robert E; Chaika, O. V.

In: Expert Opinion on Therapeutic Patents, Vol. 10, No. 2, 01.01.2000, p. 191-198.

Research output: Contribution to journalReview article

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