The viral potassium channel Kcv: Structural and functional features

Sabrina Gazzarrini, Maria Severino, Mara Lombardi, Marzia Morandi, Dario DiFrancesco, James L. Van Etten, Gerhard Thiel, Anna Moroni

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalFEBS Letters
Volume552
Issue number1
DOIs
StatePublished - Sep 18 2003

Fingerprint

Potassium Channels
Viruses
Membranes
Chlorella
Permeability
Modulation
Proteins

Keywords

  • Chlorella virus
  • K channel
  • Kcv
  • PBCV-1

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Gazzarrini, S., Severino, M., Lombardi, M., Morandi, M., DiFrancesco, D., Van Etten, J. L., ... Moroni, A. (2003). The viral potassium channel Kcv: Structural and functional features. FEBS Letters, 552(1), 12-16. https://doi.org/10.1016/S0014-5793(03)00777-4

The viral potassium channel Kcv : Structural and functional features. / Gazzarrini, Sabrina; Severino, Maria; Lombardi, Mara; Morandi, Marzia; DiFrancesco, Dario; Van Etten, James L.; Thiel, Gerhard; Moroni, Anna.

In: FEBS Letters, Vol. 552, No. 1, 18.09.2003, p. 12-16.

Research output: Contribution to journalArticle

Gazzarrini, S, Severino, M, Lombardi, M, Morandi, M, DiFrancesco, D, Van Etten, JL, Thiel, G & Moroni, A 2003, 'The viral potassium channel Kcv: Structural and functional features', FEBS Letters, vol. 552, no. 1, pp. 12-16. https://doi.org/10.1016/S0014-5793(03)00777-4
Gazzarrini S, Severino M, Lombardi M, Morandi M, DiFrancesco D, Van Etten JL et al. The viral potassium channel Kcv: Structural and functional features. FEBS Letters. 2003 Sep 18;552(1):12-16. https://doi.org/10.1016/S0014-5793(03)00777-4
Gazzarrini, Sabrina ; Severino, Maria ; Lombardi, Mara ; Morandi, Marzia ; DiFrancesco, Dario ; Van Etten, James L. ; Thiel, Gerhard ; Moroni, Anna. / The viral potassium channel Kcv : Structural and functional features. In: FEBS Letters. 2003 ; Vol. 552, No. 1. pp. 12-16.
@article{8381b901f694430ca9cae0a4b43a1478,
title = "The viral potassium channel Kcv: Structural and functional features",
abstract = "The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.",
keywords = "Chlorella virus, K channel, Kcv, PBCV-1",
author = "Sabrina Gazzarrini and Maria Severino and Mara Lombardi and Marzia Morandi and Dario DiFrancesco and {Van Etten}, {James L.} and Gerhard Thiel and Anna Moroni",
year = "2003",
month = "9",
day = "18",
doi = "10.1016/S0014-5793(03)00777-4",
language = "English (US)",
volume = "552",
pages = "12--16",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - The viral potassium channel Kcv

T2 - Structural and functional features

AU - Gazzarrini, Sabrina

AU - Severino, Maria

AU - Lombardi, Mara

AU - Morandi, Marzia

AU - DiFrancesco, Dario

AU - Van Etten, James L.

AU - Thiel, Gerhard

AU - Moroni, Anna

PY - 2003/9/18

Y1 - 2003/9/18

N2 - The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.

AB - The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.

KW - Chlorella virus

KW - K channel

KW - Kcv

KW - PBCV-1

UR - http://www.scopus.com/inward/record.url?scp=0041333866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041333866&partnerID=8YFLogxK

U2 - 10.1016/S0014-5793(03)00777-4

DO - 10.1016/S0014-5793(03)00777-4

M3 - Article

C2 - 12972145

AN - SCOPUS:0041333866

VL - 552

SP - 12

EP - 16

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -