The vertebrate retina

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The retina is an outpost of the central nervous system (CNS) with neuronal structures and proteins specialized for the transduction of light signals into a neural code that the brain can interpret. Mutations of proteins involved in phototransduction or synaptic transmission through the retina produce visual deficits ranging from subtle color vision defects to complete blindness. Although normally isolated from blood-mediated immune responses by the blood-retinal barrier, inflammatory responses, including gliosis and those mediated by the complement system, are important contributors to retinal degeneration, particularly age-related macular degeneration (ARMD). Studying immune responses in the retina and their pharmacological manipulation therefore presents a promising avenue for the treatment and prevention of retinal degeneration.

Original languageEnglish (US)
Title of host publicationNeuroimmune Pharmacology
PublisherSpringer International Publishing
Pages55-68
Number of pages14
ISBN (Electronic)9783319440224
ISBN (Print)9783319440200
DOIs
StatePublished - Jan 1 2016

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Light Signal Transduction
Vertebrates
Retina
Retinal Degeneration
Blood-Retinal Barrier
Color Vision Defects
Gliosis
Macular Degeneration
Blindness
Synaptic Transmission
Proteins
Central Nervous System
Pharmacology
Mutation
Brain

Keywords

  • Amacrine cell
  • Bipolar cell
  • Choroid
  • Cone
  • Fovea
  • Horizontal cell
  • Magnocellular ganglion cells
  • Melanopsin
  • Müller cells
  • Opsin
  • Outer segment
  • Parvocellular ganglion cells
  • Photoreceptor
  • Retina
  • Retinal ganglion cell
  • Retinal pigment epithelium
  • Ribbon
  • Rod
  • Transducin
  • mGluR6

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Thoreson, W. B. (2016). The vertebrate retina. In Neuroimmune Pharmacology (pp. 55-68). Springer International Publishing. https://doi.org/10.1007/978-3-319-44022-4_5

The vertebrate retina. / Thoreson, Wallace B.

Neuroimmune Pharmacology. Springer International Publishing, 2016. p. 55-68.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thoreson, WB 2016, The vertebrate retina. in Neuroimmune Pharmacology. Springer International Publishing, pp. 55-68. https://doi.org/10.1007/978-3-319-44022-4_5
Thoreson WB. The vertebrate retina. In Neuroimmune Pharmacology. Springer International Publishing. 2016. p. 55-68 https://doi.org/10.1007/978-3-319-44022-4_5
Thoreson, Wallace B. / The vertebrate retina. Neuroimmune Pharmacology. Springer International Publishing, 2016. pp. 55-68
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