The varied functions of Aurora kinases A and B in mitosis and carcinogenesis

Jyoti Iyer, Saili Moghe, Niveditha Rajagopalan, Manabu Furukawa, Ming Ying Tsai

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aurora kinases are master regulators of mitosis. Aurora kinase A is necessary for centrosome separation and maturation and for the assembly of a functional bipolar spindle. Aurora A's sister kinase Aurora kinase B, functions in monitoring and mediating proper chromosome-microtubule attachments and facilitating accurate cytokinesis. Errors in any of these functions of Aurora kinases can cause defects in chromosome alignment and segregation. This ultimately results in aneuploidy and genome instability. Thus, both Aurora kinases A and B either indirectly or directly influence chromosome segregation and hence, genome integrity. Therefore, it is critical to obtain a clear understanding of the control and regulation of these kinases to bring about proper chromosome segregation and mitosis. This chapter focuses on the mode by which Aurora kinases are regulated by, and regulate, various proteins in mitosis and cancer. Importantly, this chapter also brings into light the data that hint at a possible signaling cross-talk between Aurora A and Aurora B signaling pathways.

Original languageEnglish (US)
Title of host publicationNew Developments in Chromatin Research
PublisherNova Science Publishers, Inc.
Pages1-28
Number of pages28
ISBN (Print)9781620818169
StatePublished - Aug 1 2012

Fingerprint

Aurora Kinase B
Aurora Kinases
Aurora Kinase A
Chromosome Segregation
Chromosomes
Mitosis
Carcinogenesis
Phosphotransferases
Centrosome
Cytokinesis
Genes
Genomic Instability
Aneuploidy
Microtubules
Genome
Light
Defects
Monitoring
Neoplasms
Proteins

Keywords

  • Aurora A
  • Aurora B
  • Cancer
  • Cross-talk
  • Mitosis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Iyer, J., Moghe, S., Rajagopalan, N., Furukawa, M., & Tsai, M. Y. (2012). The varied functions of Aurora kinases A and B in mitosis and carcinogenesis. In New Developments in Chromatin Research (pp. 1-28). Nova Science Publishers, Inc..

The varied functions of Aurora kinases A and B in mitosis and carcinogenesis. / Iyer, Jyoti; Moghe, Saili; Rajagopalan, Niveditha; Furukawa, Manabu; Tsai, Ming Ying.

New Developments in Chromatin Research. Nova Science Publishers, Inc., 2012. p. 1-28.

Research output: Chapter in Book/Report/Conference proceedingChapter

Iyer, J, Moghe, S, Rajagopalan, N, Furukawa, M & Tsai, MY 2012, The varied functions of Aurora kinases A and B in mitosis and carcinogenesis. in New Developments in Chromatin Research. Nova Science Publishers, Inc., pp. 1-28.
Iyer J, Moghe S, Rajagopalan N, Furukawa M, Tsai MY. The varied functions of Aurora kinases A and B in mitosis and carcinogenesis. In New Developments in Chromatin Research. Nova Science Publishers, Inc. 2012. p. 1-28
Iyer, Jyoti ; Moghe, Saili ; Rajagopalan, Niveditha ; Furukawa, Manabu ; Tsai, Ming Ying. / The varied functions of Aurora kinases A and B in mitosis and carcinogenesis. New Developments in Chromatin Research. Nova Science Publishers, Inc., 2012. pp. 1-28
@inbook{e7fb53a0ed554ba6b60710f93957cdb4,
title = "The varied functions of Aurora kinases A and B in mitosis and carcinogenesis",
abstract = "Aurora kinases are master regulators of mitosis. Aurora kinase A is necessary for centrosome separation and maturation and for the assembly of a functional bipolar spindle. Aurora A's sister kinase Aurora kinase B, functions in monitoring and mediating proper chromosome-microtubule attachments and facilitating accurate cytokinesis. Errors in any of these functions of Aurora kinases can cause defects in chromosome alignment and segregation. This ultimately results in aneuploidy and genome instability. Thus, both Aurora kinases A and B either indirectly or directly influence chromosome segregation and hence, genome integrity. Therefore, it is critical to obtain a clear understanding of the control and regulation of these kinases to bring about proper chromosome segregation and mitosis. This chapter focuses on the mode by which Aurora kinases are regulated by, and regulate, various proteins in mitosis and cancer. Importantly, this chapter also brings into light the data that hint at a possible signaling cross-talk between Aurora A and Aurora B signaling pathways.",
keywords = "Aurora A, Aurora B, Cancer, Cross-talk, Mitosis",
author = "Jyoti Iyer and Saili Moghe and Niveditha Rajagopalan and Manabu Furukawa and Tsai, {Ming Ying}",
year = "2012",
month = "8",
day = "1",
language = "English (US)",
isbn = "9781620818169",
pages = "1--28",
booktitle = "New Developments in Chromatin Research",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - The varied functions of Aurora kinases A and B in mitosis and carcinogenesis

AU - Iyer, Jyoti

AU - Moghe, Saili

AU - Rajagopalan, Niveditha

AU - Furukawa, Manabu

AU - Tsai, Ming Ying

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Aurora kinases are master regulators of mitosis. Aurora kinase A is necessary for centrosome separation and maturation and for the assembly of a functional bipolar spindle. Aurora A's sister kinase Aurora kinase B, functions in monitoring and mediating proper chromosome-microtubule attachments and facilitating accurate cytokinesis. Errors in any of these functions of Aurora kinases can cause defects in chromosome alignment and segregation. This ultimately results in aneuploidy and genome instability. Thus, both Aurora kinases A and B either indirectly or directly influence chromosome segregation and hence, genome integrity. Therefore, it is critical to obtain a clear understanding of the control and regulation of these kinases to bring about proper chromosome segregation and mitosis. This chapter focuses on the mode by which Aurora kinases are regulated by, and regulate, various proteins in mitosis and cancer. Importantly, this chapter also brings into light the data that hint at a possible signaling cross-talk between Aurora A and Aurora B signaling pathways.

AB - Aurora kinases are master regulators of mitosis. Aurora kinase A is necessary for centrosome separation and maturation and for the assembly of a functional bipolar spindle. Aurora A's sister kinase Aurora kinase B, functions in monitoring and mediating proper chromosome-microtubule attachments and facilitating accurate cytokinesis. Errors in any of these functions of Aurora kinases can cause defects in chromosome alignment and segregation. This ultimately results in aneuploidy and genome instability. Thus, both Aurora kinases A and B either indirectly or directly influence chromosome segregation and hence, genome integrity. Therefore, it is critical to obtain a clear understanding of the control and regulation of these kinases to bring about proper chromosome segregation and mitosis. This chapter focuses on the mode by which Aurora kinases are regulated by, and regulate, various proteins in mitosis and cancer. Importantly, this chapter also brings into light the data that hint at a possible signaling cross-talk between Aurora A and Aurora B signaling pathways.

KW - Aurora A

KW - Aurora B

KW - Cancer

KW - Cross-talk

KW - Mitosis

UR - http://www.scopus.com/inward/record.url?scp=84895236504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84895236504&partnerID=8YFLogxK

M3 - Chapter

SN - 9781620818169

SP - 1

EP - 28

BT - New Developments in Chromatin Research

PB - Nova Science Publishers, Inc.

ER -