The utilization of intravenously infused pyridoxine in humans

Janos Zempleni, Werner Kübler

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The utilization of a usual dose of intravenously infused pyridoxine (100 mg pyridoxine hydrochloride) was investigated in ten healthy males. Blood plasma and erythrocytes were investigated by means of high-performance liquid chromatography. Detectable metabolites in blood plasma were pyridoxine, pyridoxal 5'-phosphate, pyridoxal and 4-pyridoxic acid. In erythrocytes pyridoxine, pyridoxal 5'-phosphate, pyridoxal, and pyridoxamine 5'-phosphate were found. From their concentration-time curves rate constants of elimination and invasion, volume of distribution (pyridoxine) and the areas under the curves were calculated. Values for concmax and tmax are reported. A comparison with earlier results of oral pyridoxine administration revealed a better utilization after intravenous than after oral application, i.e. a greater build-up of coenzyme forms. A regulatory phenomenon in erythrocytes caused by high doses of pyridoxine is described. In view of the potential toxicity of pyridoxine the doses used in parenteral nutrition are called into question.

Original languageEnglish (US)
Pages (from-to)27-36
Number of pages10
JournalClinica Chimica Acta
Volume229
Issue number1-2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Pyridoxine
Pyridoxal Phosphate
Erythrocytes
Pyridoxal
Pyridoxic Acid
Blood
Coenzymes
Parenteral Nutrition
Pyridoxamine
Plasmas
Area Under Curve
Oral Administration
High performance liquid chromatography
Nutrition
Metabolites
High Pressure Liquid Chromatography
Toxicity
Rate constants
Phosphates

Keywords

  • Humans
  • Intravenous infusion
  • Metabolism
  • Pharmacokinetics
  • Pyridoxine
  • Utilization

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

The utilization of intravenously infused pyridoxine in humans. / Zempleni, Janos; Kübler, Werner.

In: Clinica Chimica Acta, Vol. 229, No. 1-2, 01.01.1994, p. 27-36.

Research output: Contribution to journalArticle

Zempleni, Janos ; Kübler, Werner. / The utilization of intravenously infused pyridoxine in humans. In: Clinica Chimica Acta. 1994 ; Vol. 229, No. 1-2. pp. 27-36.
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