The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States

Colleen S. Kraft, Angela L Hewlett, Scott A Koepsell, Anne M. Winkler, Christopher J Kratochvil, Luann Larson, Jay B. Varkey, Aneesh K. Mehta, G. Marshall Lyon, Rachel J. Friedman-Moraco, Vincent C. Marconi, Charles E. Hill, James N Sullivan, Daniel W Johnson, Steven J Lisco, Mark J. Mulligan, Timothy M. Uyeki, Anita K. McElroy, Tara Sealy, Shelley CampbellChristina Spiropoulou, Ute Ströher, Ian Crozier, Richard Sacra, Michael J. Connor, Viranuj Sueblinvong, Harold A. Franch, Philip W. Smith, Bruce S. Ribner, Shelly Schwedhelm, Kate Boulter, Elizabeth L Beam, Shawn Gibbs, John-Martin J Lowe, Craig Arnold Piquette, Kristina L Bailey, Joseph Auxier, Brian Boer, Travis Hanson, Julia Kaseman, M. Salman Khan, Ji Hyun Rhee, Adam Wells, Diana F Florescu, Andre C Kalil, Mark Edmund Rupp, Valerie Becker, Bridget Boeckman, Erica Elder, Abby Fitch, Elizabeth Flood, Meagan Freml, Roman Frigge, Kelly Ann Hanzlik, Lois Jensen, Nicole Kraus, Drew Molacek, Jerry Nevins, Alicia Parker, Jeff Peters, Cheryl Rand, Karen Roesler, Kendall Ryalls, Morgan Shradar, Amanda Strain, Timothy Sunderman, Jennifer Sundermeier, John Swanhorst, Angela Vasa, Jean Bellinghausen, Frank Freihaut, Susan Denny, Lauren Mainelli, Dee Pinkney, Deborah Ray, Jay Jevne, Kalen Knight, Derrick McCroy, Ralph Nadeau, Anna Nightser, Peter Charles Iwen, Tony Sambol, Vicki Herrera, David Morgan, Sarah Trotter, Amy Kerby, Sue Peters, Timothy Southern, Caitlin Murphy, Rosanna Morris, Suzanne Nuss, Theresa Franco, Connie Ogden, Julie Lazure, Dawn Straub, Steven Heye Hinrichs, Troy J Plumb, Marius C Florescu, John Becker, Jenna Souchek, Jon Beck, Peggy Heires, Bruce Gordon, Gail Paulsen, Barb Wolford, Jill Petersen, Nedra Marion, Kim Hayes, Kate Tyner, Taylor Wilson, Paul Baltes, Jenny Nowatzke, Jonathan Nguyen, Paul Turner, Barb Boonstra, Katelyn Jelden, Randy Portrey, Doug Stringfield, Bryan Scofield, Gary Svanda, Jolene Horihan, Chris Dahl, Megan Bruno, Kelsey Malm, Ron Litz, Jessica Fehringer, Katie Paladino, Tammy Opp, Sonia Bell, Anne Adams, Mary Beth Allen, Robert Bachman, William Bornstein, Dee Cantrell, Pam Cosper, Nancye Feistritzer, John Fox, Bryce Gartland, Jen Goodman, Susan Grant, Dallis Howard-Crow, Ira Horowitz, David Pugh, Chad Ritenour, Toni Ash, Christopher Barnes, Jason Calhoun, Lauren Chapman, Tracey Daye, Haley Durr, Shunasee Evans, Janice Gentry, Jan Ginnane, Chris Haynes, Carolyn Hill, Dustin Hillis, Crystal Johnson, Jessica Loomis, Josia Mamora, Laura Mitchell, Jill Morgan, Nancy Osakwe, Jacqueline Owen, Sarah Piazza, Kristina Shirley, Jodi Siddens, Carrie Silas, Jason Slabach, Elaina Tirador, Donnette Todd, Sharon Vanairsdale, Nicole Brammer, Juli Buchanan, Eileen Burd, John Cardella, Brenda Eaves, Crystal Evans, Krista Hostetler, Karen Jenkins, Maureen Lindsey, Jordan Magee, Randall Powers, James Ritchie, Emily Ryan, Shannon Bonds, Amir Emamifar, Tish Kuban, Jan Pack, Susan Rogers, George Golston, Sean Kaufman, Patricia Olinger, Sean Olinger, Kalpana Rengarajan, Scott Thomaston, Emily Beck, Paula Desroches, Cynthia Hall, Celeste Walker, Connie Bryant, Betsy Hackman, Regina Howard, Marolyn Jones, Jeff Broughton, Brian Frisle, Robert Jackson, Jerry Lewis, Robin Brown-Haithco, Miranda Lynn Gartin, Erica Geralds-Washington, Rhonda James-Jones, Donald Miller, Dan Stark, Gentrice McGee, Porcia Jones, Linda Scott-Harris, James Cain, Roderick Davis, Tyrone Johnson, Tyrone Pickett, Anthony Shaw, Tenina Truesdale, Jim Blum, Laureen Hill, Jon Sevransky, Joel Zivot, Seth Walker, Matthew Klopman, Ricky Matkins, Cathy Meechan, Paul Meechan, Kathy Schwock, Jen Schuck, Kathy Stack, Francis Wolf, Bruce Bray, Alex Isakov, Sam Shartar, Wade Miles, Aaro Jamison, John Arevalo, Gail Stallings, Janet Christenbury, Vince Dollard, Melanie De Gennaro, Holly Korschun, Nancy Seideman, Tom Ziegler, Daniel P. Griffith, Nisha Dave, Susan Wall, Melida Hall, Dwania McGhee, Tim Clarke, Rachel Vaught, Katrina Peterson-Pileri

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.

Original languageEnglish (US)
Pages (from-to)496-502
Number of pages7
JournalClinical Infectious Diseases
Volume61
Issue number4
DOIs
StatePublished - Aug 15 2015

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Ebola Hemorrhagic Fever
Western Africa
Investigational Therapies
Renal Replacement Therapy
Artificial Respiration
Critical Illness
Disease Outbreaks
Patient Care
Clinical Trials
Therapeutics
Pharmaceutical Preparations

Keywords

  • Ebola virus
  • Ebola virus disease
  • TKM-Ebola
  • convalescent plasma
  • convalescent serum

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States. / Kraft, Colleen S.; Hewlett, Angela L; Koepsell, Scott A; Winkler, Anne M.; Kratochvil, Christopher J; Larson, Luann; Varkey, Jay B.; Mehta, Aneesh K.; Lyon, G. Marshall; Friedman-Moraco, Rachel J.; Marconi, Vincent C.; Hill, Charles E.; Sullivan, James N; Johnson, Daniel W; Lisco, Steven J; Mulligan, Mark J.; Uyeki, Timothy M.; McElroy, Anita K.; Sealy, Tara; Campbell, Shelley; Spiropoulou, Christina; Ströher, Ute; Crozier, Ian; Sacra, Richard; Connor, Michael J.; Sueblinvong, Viranuj; Franch, Harold A.; Smith, Philip W.; Ribner, Bruce S.; Schwedhelm, Shelly; Boulter, Kate; Beam, Elizabeth L; Gibbs, Shawn; Lowe, John-Martin J; Piquette, Craig Arnold; Bailey, Kristina L; Auxier, Joseph; Boer, Brian; Hanson, Travis; Kaseman, Julia; Khan, M. Salman; Rhee, Ji Hyun; Wells, Adam; Florescu, Diana F; Kalil, Andre C; Rupp, Mark Edmund; Becker, Valerie; Boeckman, Bridget; Elder, Erica; Fitch, Abby; Flood, Elizabeth; Freml, Meagan; Frigge, Roman; Hanzlik, Kelly Ann; Jensen, Lois; Kraus, Nicole; Molacek, Drew; Nevins, Jerry; Parker, Alicia; Peters, Jeff; Rand, Cheryl; Roesler, Karen; Ryalls, Kendall; Shradar, Morgan; Strain, Amanda; Sunderman, Timothy; Sundermeier, Jennifer; Swanhorst, John; Vasa, Angela; Bellinghausen, Jean; Freihaut, Frank; Denny, Susan; Mainelli, Lauren; Pinkney, Dee; Ray, Deborah; Jevne, Jay; Knight, Kalen; McCroy, Derrick; Nadeau, Ralph; Nightser, Anna; Iwen, Peter Charles; Sambol, Tony; Herrera, Vicki; Morgan, David; Trotter, Sarah; Kerby, Amy; Peters, Sue; Southern, Timothy; Murphy, Caitlin; Morris, Rosanna; Nuss, Suzanne; Franco, Theresa; Ogden, Connie; Lazure, Julie; Straub, Dawn; Hinrichs, Steven Heye; Plumb, Troy J; Florescu, Marius C; Becker, John; Souchek, Jenna; Beck, Jon; Heires, Peggy; Gordon, Bruce; Paulsen, Gail; Wolford, Barb; Petersen, Jill; Marion, Nedra; Hayes, Kim; Tyner, Kate; Wilson, Taylor; Baltes, Paul; Nowatzke, Jenny; Nguyen, Jonathan; Turner, Paul; Boonstra, Barb; Jelden, Katelyn; Portrey, Randy; Stringfield, Doug; Scofield, Bryan; Svanda, Gary; Horihan, Jolene; Dahl, Chris; Bruno, Megan; Malm, Kelsey; Litz, Ron; Fehringer, Jessica; Paladino, Katie; Opp, Tammy; Bell, Sonia; Adams, Anne; Allen, Mary Beth; Bachman, Robert; Bornstein, William; Cantrell, Dee; Cosper, Pam; Feistritzer, Nancye; Fox, John; Gartland, Bryce; Goodman, Jen; Grant, Susan; Howard-Crow, Dallis; Horowitz, Ira; Pugh, David; Ritenour, Chad; Ash, Toni; Barnes, Christopher; Calhoun, Jason; Chapman, Lauren; Daye, Tracey; Durr, Haley; Evans, Shunasee; Gentry, Janice; Ginnane, Jan; Haynes, Chris; Hill, Carolyn; Hillis, Dustin; Johnson, Crystal; Loomis, Jessica; Mamora, Josia; Mitchell, Laura; Morgan, Jill; Osakwe, Nancy; Owen, Jacqueline; Piazza, Sarah; Shirley, Kristina; Siddens, Jodi; Silas, Carrie; Slabach, Jason; Tirador, Elaina; Todd, Donnette; Vanairsdale, Sharon; Brammer, Nicole; Buchanan, Juli; Burd, Eileen; Cardella, John; Eaves, Brenda; Evans, Crystal; Hostetler, Krista; Jenkins, Karen; Lindsey, Maureen; Magee, Jordan; Powers, Randall; Ritchie, James; Ryan, Emily; Bonds, Shannon; Emamifar, Amir; Kuban, Tish; Pack, Jan; Rogers, Susan; Golston, George; Kaufman, Sean; Olinger, Patricia; Olinger, Sean; Rengarajan, Kalpana; Thomaston, Scott; Beck, Emily; Desroches, Paula; Hall, Cynthia; Walker, Celeste; Bryant, Connie; Hackman, Betsy; Howard, Regina; Jones, Marolyn; Broughton, Jeff; Frisle, Brian; Jackson, Robert; Lewis, Jerry; Brown-Haithco, Robin; Gartin, Miranda Lynn; Geralds-Washington, Erica; James-Jones, Rhonda; Miller, Donald; Stark, Dan; McGee, Gentrice; Jones, Porcia; Scott-Harris, Linda; Cain, James; Davis, Roderick; Johnson, Tyrone; Pickett, Tyrone; Shaw, Anthony; Truesdale, Tenina; Blum, Jim; Hill, Laureen; Sevransky, Jon; Zivot, Joel; Walker, Seth; Klopman, Matthew; Matkins, Ricky; Meechan, Cathy; Meechan, Paul; Schwock, Kathy; Schuck, Jen; Stack, Kathy; Wolf, Francis; Bray, Bruce; Isakov, Alex; Shartar, Sam; Miles, Wade; Jamison, Aaro; Arevalo, John; Stallings, Gail; Christenbury, Janet; Dollard, Vince; De Gennaro, Melanie; Korschun, Holly; Seideman, Nancy; Ziegler, Tom; Griffith, Daniel P.; Dave, Nisha; Wall, Susan; Hall, Melida; McGhee, Dwania; Clarke, Tim; Vaught, Rachel; Peterson-Pileri, Katrina.

In: Clinical Infectious Diseases, Vol. 61, No. 4, 15.08.2015, p. 496-502.

Research output: Contribution to journalArticle

Kraft, CS, Hewlett, AL, Koepsell, SA, Winkler, AM, Kratochvil, CJ, Larson, L, Varkey, JB, Mehta, AK, Lyon, GM, Friedman-Moraco, RJ, Marconi, VC, Hill, CE, Sullivan, JN, Johnson, DW, Lisco, SJ, Mulligan, MJ, Uyeki, TM, McElroy, AK, Sealy, T, Campbell, S, Spiropoulou, C, Ströher, U, Crozier, I, Sacra, R, Connor, MJ, Sueblinvong, V, Franch, HA, Smith, PW, Ribner, BS, Schwedhelm, S, Boulter, K, Beam, EL, Gibbs, S, Lowe, J-MJ, Piquette, CA, Bailey, KL, Auxier, J, Boer, B, Hanson, T, Kaseman, J, Khan, MS, Rhee, JH, Wells, A, Florescu, DF, Kalil, AC, Rupp, ME, Becker, V, Boeckman, B, Elder, E, Fitch, A, Flood, E, Freml, M, Frigge, R, Hanzlik, KA, Jensen, L, Kraus, N, Molacek, D, Nevins, J, Parker, A, Peters, J, Rand, C, Roesler, K, Ryalls, K, Shradar, M, Strain, A, Sunderman, T, Sundermeier, J, Swanhorst, J, Vasa, A, Bellinghausen, J, Freihaut, F, Denny, S, Mainelli, L, Pinkney, D, Ray, D, Jevne, J, Knight, K, McCroy, D, Nadeau, R, Nightser, A, Iwen, PC, Sambol, T, Herrera, V, Morgan, D, Trotter, S, Kerby, A, Peters, S, Southern, T, Murphy, C, Morris, R, Nuss, S, Franco, T, Ogden, C, Lazure, J, Straub, D, Hinrichs, SH, Plumb, TJ, Florescu, MC, Becker, J, Souchek, J, Beck, J, Heires, P, Gordon, B, Paulsen, G, Wolford, B, Petersen, J, Marion, N, Hayes, K, Tyner, K, Wilson, T, Baltes, P, Nowatzke, J, Nguyen, J, Turner, P, Boonstra, B, Jelden, K, Portrey, R, Stringfield, D, Scofield, B, Svanda, G, Horihan, J, Dahl, C, Bruno, M, Malm, K, Litz, R, Fehringer, J, Paladino, K, Opp, T, Bell, S, Adams, A, Allen, MB, Bachman, R, Bornstein, W, Cantrell, D, Cosper, P, Feistritzer, N, Fox, J, Gartland, B, Goodman, J, Grant, S, Howard-Crow, D, Horowitz, I, Pugh, D, Ritenour, C, Ash, T, Barnes, C, Calhoun, J, Chapman, L, Daye, T, Durr, H, Evans, S, Gentry, J, Ginnane, J, Haynes, C, Hill, C, Hillis, D, Johnson, C, Loomis, J, Mamora, J, Mitchell, L, Morgan, J, Osakwe, N, Owen, J, Piazza, S, Shirley, K, Siddens, J, Silas, C, Slabach, J, Tirador, E, Todd, D, Vanairsdale, S, Brammer, N, Buchanan, J, Burd, E, Cardella, J, Eaves, B, Evans, C, Hostetler, K, Jenkins, K, Lindsey, M, Magee, J, Powers, R, Ritchie, J, Ryan, E, Bonds, S, Emamifar, A, Kuban, T, Pack, J, Rogers, S, Golston, G, Kaufman, S, Olinger, P, Olinger, S, Rengarajan, K, Thomaston, S, Beck, E, Desroches, P, Hall, C, Walker, C, Bryant, C, Hackman, B, Howard, R, Jones, M, Broughton, J, Frisle, B, Jackson, R, Lewis, J, Brown-Haithco, R, Gartin, ML, Geralds-Washington, E, James-Jones, R, Miller, D, Stark, D, McGee, G, Jones, P, Scott-Harris, L, Cain, J, Davis, R, Johnson, T, Pickett, T, Shaw, A, Truesdale, T, Blum, J, Hill, L, Sevransky, J, Zivot, J, Walker, S, Klopman, M, Matkins, R, Meechan, C, Meechan, P, Schwock, K, Schuck, J, Stack, K, Wolf, F, Bray, B, Isakov, A, Shartar, S, Miles, W, Jamison, A, Arevalo, J, Stallings, G, Christenbury, J, Dollard, V, De Gennaro, M, Korschun, H, Seideman, N, Ziegler, T, Griffith, DP, Dave, N, Wall, S, Hall, M, McGhee, D, Clarke, T, Vaught, R & Peterson-Pileri, K 2015, 'The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States', Clinical Infectious Diseases, vol. 61, no. 4, pp. 496-502. https://doi.org/10.1093/cid/civ334
Kraft, Colleen S. ; Hewlett, Angela L ; Koepsell, Scott A ; Winkler, Anne M. ; Kratochvil, Christopher J ; Larson, Luann ; Varkey, Jay B. ; Mehta, Aneesh K. ; Lyon, G. Marshall ; Friedman-Moraco, Rachel J. ; Marconi, Vincent C. ; Hill, Charles E. ; Sullivan, James N ; Johnson, Daniel W ; Lisco, Steven J ; Mulligan, Mark J. ; Uyeki, Timothy M. ; McElroy, Anita K. ; Sealy, Tara ; Campbell, Shelley ; Spiropoulou, Christina ; Ströher, Ute ; Crozier, Ian ; Sacra, Richard ; Connor, Michael J. ; Sueblinvong, Viranuj ; Franch, Harold A. ; Smith, Philip W. ; Ribner, Bruce S. ; Schwedhelm, Shelly ; Boulter, Kate ; Beam, Elizabeth L ; Gibbs, Shawn ; Lowe, John-Martin J ; Piquette, Craig Arnold ; Bailey, Kristina L ; Auxier, Joseph ; Boer, Brian ; Hanson, Travis ; Kaseman, Julia ; Khan, M. Salman ; Rhee, Ji Hyun ; Wells, Adam ; Florescu, Diana F ; Kalil, Andre C ; Rupp, Mark Edmund ; Becker, Valerie ; Boeckman, Bridget ; Elder, Erica ; Fitch, Abby ; Flood, Elizabeth ; Freml, Meagan ; Frigge, Roman ; Hanzlik, Kelly Ann ; Jensen, Lois ; Kraus, Nicole ; Molacek, Drew ; Nevins, Jerry ; Parker, Alicia ; Peters, Jeff ; Rand, Cheryl ; Roesler, Karen ; Ryalls, Kendall ; Shradar, Morgan ; Strain, Amanda ; Sunderman, Timothy ; Sundermeier, Jennifer ; Swanhorst, John ; Vasa, Angela ; Bellinghausen, Jean ; Freihaut, Frank ; Denny, Susan ; Mainelli, Lauren ; Pinkney, Dee ; Ray, Deborah ; Jevne, Jay ; Knight, Kalen ; McCroy, Derrick ; Nadeau, Ralph ; Nightser, Anna ; Iwen, Peter Charles ; Sambol, Tony ; Herrera, Vicki ; Morgan, David ; Trotter, Sarah ; Kerby, Amy ; Peters, Sue ; Southern, Timothy ; Murphy, Caitlin ; Morris, Rosanna ; Nuss, Suzanne ; Franco, Theresa ; Ogden, Connie ; Lazure, Julie ; Straub, Dawn ; Hinrichs, Steven Heye ; Plumb, Troy J ; Florescu, Marius C ; Becker, John ; Souchek, Jenna ; Beck, Jon ; Heires, Peggy ; Gordon, Bruce ; Paulsen, Gail ; Wolford, Barb ; Petersen, Jill ; Marion, Nedra ; Hayes, Kim ; Tyner, Kate ; Wilson, Taylor ; Baltes, Paul ; Nowatzke, Jenny ; Nguyen, Jonathan ; Turner, Paul ; Boonstra, Barb ; Jelden, Katelyn ; Portrey, Randy ; Stringfield, Doug ; Scofield, Bryan ; Svanda, Gary ; Horihan, Jolene ; Dahl, Chris ; Bruno, Megan ; Malm, Kelsey ; Litz, Ron ; Fehringer, Jessica ; Paladino, Katie ; Opp, Tammy ; Bell, Sonia ; Adams, Anne ; Allen, Mary Beth ; Bachman, Robert ; Bornstein, William ; Cantrell, Dee ; Cosper, Pam ; Feistritzer, Nancye ; Fox, John ; Gartland, Bryce ; Goodman, Jen ; Grant, Susan ; Howard-Crow, Dallis ; Horowitz, Ira ; Pugh, David ; Ritenour, Chad ; Ash, Toni ; Barnes, Christopher ; Calhoun, Jason ; Chapman, Lauren ; Daye, Tracey ; Durr, Haley ; Evans, Shunasee ; Gentry, Janice ; Ginnane, Jan ; Haynes, Chris ; Hill, Carolyn ; Hillis, Dustin ; Johnson, Crystal ; Loomis, Jessica ; Mamora, Josia ; Mitchell, Laura ; Morgan, Jill ; Osakwe, Nancy ; Owen, Jacqueline ; Piazza, Sarah ; Shirley, Kristina ; Siddens, Jodi ; Silas, Carrie ; Slabach, Jason ; Tirador, Elaina ; Todd, Donnette ; Vanairsdale, Sharon ; Brammer, Nicole ; Buchanan, Juli ; Burd, Eileen ; Cardella, John ; Eaves, Brenda ; Evans, Crystal ; Hostetler, Krista ; Jenkins, Karen ; Lindsey, Maureen ; Magee, Jordan ; Powers, Randall ; Ritchie, James ; Ryan, Emily ; Bonds, Shannon ; Emamifar, Amir ; Kuban, Tish ; Pack, Jan ; Rogers, Susan ; Golston, George ; Kaufman, Sean ; Olinger, Patricia ; Olinger, Sean ; Rengarajan, Kalpana ; Thomaston, Scott ; Beck, Emily ; Desroches, Paula ; Hall, Cynthia ; Walker, Celeste ; Bryant, Connie ; Hackman, Betsy ; Howard, Regina ; Jones, Marolyn ; Broughton, Jeff ; Frisle, Brian ; Jackson, Robert ; Lewis, Jerry ; Brown-Haithco, Robin ; Gartin, Miranda Lynn ; Geralds-Washington, Erica ; James-Jones, Rhonda ; Miller, Donald ; Stark, Dan ; McGee, Gentrice ; Jones, Porcia ; Scott-Harris, Linda ; Cain, James ; Davis, Roderick ; Johnson, Tyrone ; Pickett, Tyrone ; Shaw, Anthony ; Truesdale, Tenina ; Blum, Jim ; Hill, Laureen ; Sevransky, Jon ; Zivot, Joel ; Walker, Seth ; Klopman, Matthew ; Matkins, Ricky ; Meechan, Cathy ; Meechan, Paul ; Schwock, Kathy ; Schuck, Jen ; Stack, Kathy ; Wolf, Francis ; Bray, Bruce ; Isakov, Alex ; Shartar, Sam ; Miles, Wade ; Jamison, Aaro ; Arevalo, John ; Stallings, Gail ; Christenbury, Janet ; Dollard, Vince ; De Gennaro, Melanie ; Korschun, Holly ; Seideman, Nancy ; Ziegler, Tom ; Griffith, Daniel P. ; Dave, Nisha ; Wall, Susan ; Hall, Melida ; McGhee, Dwania ; Clarke, Tim ; Vaught, Rachel ; Peterson-Pileri, Katrina. / The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States. In: Clinical Infectious Diseases. 2015 ; Vol. 61, No. 4. pp. 496-502.
@article{3529c5e645874bbe88cb1be69960830b,
title = "The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States",
abstract = "Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.",
keywords = "Ebola virus, Ebola virus disease, TKM-Ebola, convalescent plasma, convalescent serum",
author = "Kraft, {Colleen S.} and Hewlett, {Angela L} and Koepsell, {Scott A} and Winkler, {Anne M.} and Kratochvil, {Christopher J} and Luann Larson and Varkey, {Jay B.} and Mehta, {Aneesh K.} and Lyon, {G. Marshall} and Friedman-Moraco, {Rachel J.} and Marconi, {Vincent C.} and Hill, {Charles E.} and Sullivan, {James N} and Johnson, {Daniel W} and Lisco, {Steven J} and Mulligan, {Mark J.} and Uyeki, {Timothy M.} and McElroy, {Anita K.} and Tara Sealy and Shelley Campbell and Christina Spiropoulou and Ute Str{\"o}her and Ian Crozier and Richard Sacra and Connor, {Michael J.} and Viranuj Sueblinvong and Franch, {Harold A.} and Smith, {Philip W.} and Ribner, {Bruce S.} and Shelly Schwedhelm and Kate Boulter and Beam, {Elizabeth L} and Shawn Gibbs and Lowe, {John-Martin J} and Piquette, {Craig Arnold} and Bailey, {Kristina L} and Joseph Auxier and Brian Boer and Travis Hanson and Julia Kaseman and Khan, {M. Salman} and Rhee, {Ji Hyun} and Adam Wells and Florescu, {Diana F} and Kalil, {Andre C} and Rupp, {Mark Edmund} and Valerie Becker and Bridget Boeckman and Erica Elder and Abby Fitch and Elizabeth Flood and Meagan Freml and Roman Frigge and Hanzlik, {Kelly Ann} and Lois Jensen and Nicole Kraus and Drew Molacek and Jerry Nevins and Alicia Parker and Jeff Peters and Cheryl Rand and Karen Roesler and Kendall Ryalls and Morgan Shradar and Amanda Strain and Timothy Sunderman and Jennifer Sundermeier and John Swanhorst and Angela Vasa and Jean Bellinghausen and Frank Freihaut and Susan Denny and Lauren Mainelli and Dee Pinkney and Deborah Ray and Jay Jevne and Kalen Knight and Derrick McCroy and Ralph Nadeau and Anna Nightser and Iwen, {Peter Charles} and Tony Sambol and Vicki Herrera and David Morgan and Sarah Trotter and Amy Kerby and Sue Peters and Timothy Southern and Caitlin Murphy and Rosanna Morris and Suzanne Nuss and Theresa Franco and Connie Ogden and Julie Lazure and Dawn Straub and Hinrichs, {Steven Heye} and Plumb, {Troy J} and Florescu, {Marius C} and John Becker and Jenna Souchek and Jon Beck and Peggy Heires and Bruce Gordon and Gail Paulsen and Barb Wolford and Jill Petersen and Nedra Marion and Kim Hayes and Kate Tyner and Taylor Wilson and Paul Baltes and Jenny Nowatzke and Jonathan Nguyen and Paul Turner and Barb Boonstra and Katelyn Jelden and Randy Portrey and Doug Stringfield and Bryan Scofield and Gary Svanda and Jolene Horihan and Chris Dahl and Megan Bruno and Kelsey Malm and Ron Litz and Jessica Fehringer and Katie Paladino and Tammy Opp and Sonia Bell and Anne Adams and Allen, {Mary Beth} and Robert Bachman and William Bornstein and Dee Cantrell and Pam Cosper and Nancye Feistritzer and John Fox and Bryce Gartland and Jen Goodman and Susan Grant and Dallis Howard-Crow and Ira Horowitz and David Pugh and Chad Ritenour and Toni Ash and Christopher Barnes and Jason Calhoun and Lauren Chapman and Tracey Daye and Haley Durr and Shunasee Evans and Janice Gentry and Jan Ginnane and Chris Haynes and Carolyn Hill and Dustin Hillis and Crystal Johnson and Jessica Loomis and Josia Mamora and Laura Mitchell and Jill Morgan and Nancy Osakwe and Jacqueline Owen and Sarah Piazza and Kristina Shirley and Jodi Siddens and Carrie Silas and Jason Slabach and Elaina Tirador and Donnette Todd and Sharon Vanairsdale and Nicole Brammer and Juli Buchanan and Eileen Burd and John Cardella and Brenda Eaves and Crystal Evans and Krista Hostetler and Karen Jenkins and Maureen Lindsey and Jordan Magee and Randall Powers and James Ritchie and Emily Ryan and Shannon Bonds and Amir Emamifar and Tish Kuban and Jan Pack and Susan Rogers and George Golston and Sean Kaufman and Patricia Olinger and Sean Olinger and Kalpana Rengarajan and Scott Thomaston and Emily Beck and Paula Desroches and Cynthia Hall and Celeste Walker and Connie Bryant and Betsy Hackman and Regina Howard and Marolyn Jones and Jeff Broughton and Brian Frisle and Robert Jackson and Jerry Lewis and Robin Brown-Haithco and Gartin, {Miranda Lynn} and Erica Geralds-Washington and Rhonda James-Jones and Donald Miller and Dan Stark and Gentrice McGee and Porcia Jones and Linda Scott-Harris and James Cain and Roderick Davis and Tyrone Johnson and Tyrone Pickett and Anthony Shaw and Tenina Truesdale and Jim Blum and Laureen Hill and Jon Sevransky and Joel Zivot and Seth Walker and Matthew Klopman and Ricky Matkins and Cathy Meechan and Paul Meechan and Kathy Schwock and Jen Schuck and Kathy Stack and Francis Wolf and Bruce Bray and Alex Isakov and Sam Shartar and Wade Miles and Aaro Jamison and John Arevalo and Gail Stallings and Janet Christenbury and Vince Dollard and {De Gennaro}, Melanie and Holly Korschun and Nancy Seideman and Tom Ziegler and Griffith, {Daniel P.} and Nisha Dave and Susan Wall and Melida Hall and Dwania McGhee and Tim Clarke and Rachel Vaught and Katrina Peterson-Pileri",
year = "2015",
month = "8",
day = "15",
doi = "10.1093/cid/civ334",
language = "English (US)",
volume = "61",
pages = "496--502",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "4",

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TY - JOUR

T1 - The Use of TKM-100802 and Convalescent Plasma in 2 Patients with Ebola Virus Disease in the United States

AU - Kraft, Colleen S.

AU - Hewlett, Angela L

AU - Koepsell, Scott A

AU - Winkler, Anne M.

AU - Kratochvil, Christopher J

AU - Larson, Luann

AU - Varkey, Jay B.

AU - Mehta, Aneesh K.

AU - Lyon, G. Marshall

AU - Friedman-Moraco, Rachel J.

AU - Marconi, Vincent C.

AU - Hill, Charles E.

AU - Sullivan, James N

AU - Johnson, Daniel W

AU - Lisco, Steven J

AU - Mulligan, Mark J.

AU - Uyeki, Timothy M.

AU - McElroy, Anita K.

AU - Sealy, Tara

AU - Campbell, Shelley

AU - Spiropoulou, Christina

AU - Ströher, Ute

AU - Crozier, Ian

AU - Sacra, Richard

AU - Connor, Michael J.

AU - Sueblinvong, Viranuj

AU - Franch, Harold A.

AU - Smith, Philip W.

AU - Ribner, Bruce S.

AU - Schwedhelm, Shelly

AU - Boulter, Kate

AU - Beam, Elizabeth L

AU - Gibbs, Shawn

AU - Lowe, John-Martin J

AU - Piquette, Craig Arnold

AU - Bailey, Kristina L

AU - Auxier, Joseph

AU - Boer, Brian

AU - Hanson, Travis

AU - Kaseman, Julia

AU - Khan, M. Salman

AU - Rhee, Ji Hyun

AU - Wells, Adam

AU - Florescu, Diana F

AU - Kalil, Andre C

AU - Rupp, Mark Edmund

AU - Becker, Valerie

AU - Boeckman, Bridget

AU - Elder, Erica

AU - Fitch, Abby

AU - Flood, Elizabeth

AU - Freml, Meagan

AU - Frigge, Roman

AU - Hanzlik, Kelly Ann

AU - Jensen, Lois

AU - Kraus, Nicole

AU - Molacek, Drew

AU - Nevins, Jerry

AU - Parker, Alicia

AU - Peters, Jeff

AU - Rand, Cheryl

AU - Roesler, Karen

AU - Ryalls, Kendall

AU - Shradar, Morgan

AU - Strain, Amanda

AU - Sunderman, Timothy

AU - Sundermeier, Jennifer

AU - Swanhorst, John

AU - Vasa, Angela

AU - Bellinghausen, Jean

AU - Freihaut, Frank

AU - Denny, Susan

AU - Mainelli, Lauren

AU - Pinkney, Dee

AU - Ray, Deborah

AU - Jevne, Jay

AU - Knight, Kalen

AU - McCroy, Derrick

AU - Nadeau, Ralph

AU - Nightser, Anna

AU - Iwen, Peter Charles

AU - Sambol, Tony

AU - Herrera, Vicki

AU - Morgan, David

AU - Trotter, Sarah

AU - Kerby, Amy

AU - Peters, Sue

AU - Southern, Timothy

AU - Murphy, Caitlin

AU - Morris, Rosanna

AU - Nuss, Suzanne

AU - Franco, Theresa

AU - Ogden, Connie

AU - Lazure, Julie

AU - Straub, Dawn

AU - Hinrichs, Steven Heye

AU - Plumb, Troy J

AU - Florescu, Marius C

AU - Becker, John

AU - Souchek, Jenna

AU - Beck, Jon

AU - Heires, Peggy

AU - Gordon, Bruce

AU - Paulsen, Gail

AU - Wolford, Barb

AU - Petersen, Jill

AU - Marion, Nedra

AU - Hayes, Kim

AU - Tyner, Kate

AU - Wilson, Taylor

AU - Baltes, Paul

AU - Nowatzke, Jenny

AU - Nguyen, Jonathan

AU - Turner, Paul

AU - Boonstra, Barb

AU - Jelden, Katelyn

AU - Portrey, Randy

AU - Stringfield, Doug

AU - Scofield, Bryan

AU - Svanda, Gary

AU - Horihan, Jolene

AU - Dahl, Chris

AU - Bruno, Megan

AU - Malm, Kelsey

AU - Litz, Ron

AU - Fehringer, Jessica

AU - Paladino, Katie

AU - Opp, Tammy

AU - Bell, Sonia

AU - Adams, Anne

AU - Allen, Mary Beth

AU - Bachman, Robert

AU - Bornstein, William

AU - Cantrell, Dee

AU - Cosper, Pam

AU - Feistritzer, Nancye

AU - Fox, John

AU - Gartland, Bryce

AU - Goodman, Jen

AU - Grant, Susan

AU - Howard-Crow, Dallis

AU - Horowitz, Ira

AU - Pugh, David

AU - Ritenour, Chad

AU - Ash, Toni

AU - Barnes, Christopher

AU - Calhoun, Jason

AU - Chapman, Lauren

AU - Daye, Tracey

AU - Durr, Haley

AU - Evans, Shunasee

AU - Gentry, Janice

AU - Ginnane, Jan

AU - Haynes, Chris

AU - Hill, Carolyn

AU - Hillis, Dustin

AU - Johnson, Crystal

AU - Loomis, Jessica

AU - Mamora, Josia

AU - Mitchell, Laura

AU - Morgan, Jill

AU - Osakwe, Nancy

AU - Owen, Jacqueline

AU - Piazza, Sarah

AU - Shirley, Kristina

AU - Siddens, Jodi

AU - Silas, Carrie

AU - Slabach, Jason

AU - Tirador, Elaina

AU - Todd, Donnette

AU - Vanairsdale, Sharon

AU - Brammer, Nicole

AU - Buchanan, Juli

AU - Burd, Eileen

AU - Cardella, John

AU - Eaves, Brenda

AU - Evans, Crystal

AU - Hostetler, Krista

AU - Jenkins, Karen

AU - Lindsey, Maureen

AU - Magee, Jordan

AU - Powers, Randall

AU - Ritchie, James

AU - Ryan, Emily

AU - Bonds, Shannon

AU - Emamifar, Amir

AU - Kuban, Tish

AU - Pack, Jan

AU - Rogers, Susan

AU - Golston, George

AU - Kaufman, Sean

AU - Olinger, Patricia

AU - Olinger, Sean

AU - Rengarajan, Kalpana

AU - Thomaston, Scott

AU - Beck, Emily

AU - Desroches, Paula

AU - Hall, Cynthia

AU - Walker, Celeste

AU - Bryant, Connie

AU - Hackman, Betsy

AU - Howard, Regina

AU - Jones, Marolyn

AU - Broughton, Jeff

AU - Frisle, Brian

AU - Jackson, Robert

AU - Lewis, Jerry

AU - Brown-Haithco, Robin

AU - Gartin, Miranda Lynn

AU - Geralds-Washington, Erica

AU - James-Jones, Rhonda

AU - Miller, Donald

AU - Stark, Dan

AU - McGee, Gentrice

AU - Jones, Porcia

AU - Scott-Harris, Linda

AU - Cain, James

AU - Davis, Roderick

AU - Johnson, Tyrone

AU - Pickett, Tyrone

AU - Shaw, Anthony

AU - Truesdale, Tenina

AU - Blum, Jim

AU - Hill, Laureen

AU - Sevransky, Jon

AU - Zivot, Joel

AU - Walker, Seth

AU - Klopman, Matthew

AU - Matkins, Ricky

AU - Meechan, Cathy

AU - Meechan, Paul

AU - Schwock, Kathy

AU - Schuck, Jen

AU - Stack, Kathy

AU - Wolf, Francis

AU - Bray, Bruce

AU - Isakov, Alex

AU - Shartar, Sam

AU - Miles, Wade

AU - Jamison, Aaro

AU - Arevalo, John

AU - Stallings, Gail

AU - Christenbury, Janet

AU - Dollard, Vince

AU - De Gennaro, Melanie

AU - Korschun, Holly

AU - Seideman, Nancy

AU - Ziegler, Tom

AU - Griffith, Daniel P.

AU - Dave, Nisha

AU - Wall, Susan

AU - Hall, Melida

AU - McGhee, Dwania

AU - Clarke, Tim

AU - Vaught, Rachel

AU - Peterson-Pileri, Katrina

PY - 2015/8/15

Y1 - 2015/8/15

N2 - Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.

AB - Background. The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management. Methods. We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma. Results. While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date. Conclusions. It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.

KW - Ebola virus

KW - Ebola virus disease

KW - TKM-Ebola

KW - convalescent plasma

KW - convalescent serum

UR - http://www.scopus.com/inward/record.url?scp=84931448280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931448280&partnerID=8YFLogxK

U2 - 10.1093/cid/civ334

DO - 10.1093/cid/civ334

M3 - Article

C2 - 25904375

AN - SCOPUS:84931448280

VL - 61

SP - 496

EP - 502

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 4

ER -