The use of pegorgotein in the treatment of frostbite

Robert Leo Muelleman, P. Matthew Grandstaff, William A. Robinson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Free oxygen radicals have been postulated to be an important mediator of injury in frostbite. A long-acting version of the endogenous scavenger enzyme, superoxide dismutase, has been created by conjugating it with polyethylene glycol (pegorgotein, formerly known as PEG-SOD). This study evaluated the efficacy of pegorgotein on frostbite tissue survival when administered prior to rewarming. In a prospective study, two groups of nine rabbits received a standardized frostbite injury using a modified Weatherley- White model. A control group received no pharmacologic therapy; the treatment group received 10 000 IU/kg pegorgotein intravenously immediately postinjury. Healing was followed until a clear line of demarcation was apparent (10 days). The percentage of viable ear surface remaining at the end of the study was measured and used to compare the effectiveness of treatment. Student's t- test was used to determine statistical significance. The study was designed to have an 80% ability to detect a 35% difference in tissue survival. No significant difference in frostbite injury (p = 0.967) was observed between the control and treatment groups. The treatment group showed a 9.3 ± 15.5% tissue survival, whereas the control group had 9.6 ± 14.5% tissue survival. These results indicate no significant treatment effect for pegorgotein on tissue survival in a rabbit frostbite injury model when administered immediately postinjury.

Original languageEnglish (US)
Pages (from-to)17-19
Number of pages3
JournalWilderness and Environmental Medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1997

Fingerprint

Frostbite
Tissue Survival
Wounds and Injuries
Control Groups
Rabbits
Therapeutics
Rewarming
Superoxide Dismutase
Free Radicals
Ear
Reactive Oxygen Species
polyethylene glycol-superoxide dismutase
Prospective Studies
Students
Enzymes

Keywords

  • Free radical scavengers
  • Frostbite
  • Pegorgotein

ASJC Scopus subject areas

  • Emergency Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine
  • Critical Care and Intensive Care Medicine
  • Public Health, Environmental and Occupational Health

Cite this

The use of pegorgotein in the treatment of frostbite. / Muelleman, Robert Leo; Matthew Grandstaff, P.; Robinson, William A.

In: Wilderness and Environmental Medicine, Vol. 8, No. 1, 01.01.1997, p. 17-19.

Research output: Contribution to journalArticle

Muelleman, Robert Leo ; Matthew Grandstaff, P. ; Robinson, William A. / The use of pegorgotein in the treatment of frostbite. In: Wilderness and Environmental Medicine. 1997 ; Vol. 8, No. 1. pp. 17-19.
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