Abstract
Most studies of immunosuppressive therapy (IST) in myelodysplastic syndromes (MDS) are limited by small numbers and their single-center nature, and report conflicting data regarding predictors for response to IST.We examined outcomes associated with IST and predictors of benefit in a large international cohort of patientswith MDS. Datawere collected from 15 centers in the United States and Europe. Responses, including red blood cell (RBC) transfusion independence (TI), were assessed based on the 2006MDS InternationalWorking Group criteria, and overall survival (OS) was estimated by Kaplan-Meier methods. Logistic regression models estimated odds for response and TI, and Cox Proportional Hazard models estimated hazards ratios forOS.Weidentified 207patientswithMDSreceiving IST, excluding steroidmonotherapy. Themost common IST regimen was anti-thymocyte globulin (ATG) plus prednisone (43%). Overall response rate (ORR) was 48.8%, including 11.2% (95% confidence interval [CI], 6.5%-18.4%)who achieved a complete remission and 30% (95% CI, 22.3%-39.5%) who achieved RBC TI. Median OS was 47.4 months (95% CI, 37-72.3 months) and was longer for patients who achieved a response or TI. Achievement of RBC TI was associated with a hypocellular bone marrow(cellularity, 20%); horse ATG plus cyclosporinewas more effective than rabbit ATG or ATG without cyclosporine. Age, transfusion dependence, presence of paroxysmal nocturnal hemoglobinuria or large granular lymphocyte clones, and HLA DR15 positivity did not predict response to IST. IST leads to objective responses in nearly half the selected patients with the highest rate of RBC TI achieved in patients with hypocellular bone marrows.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1765-1772 |
| Number of pages | 8 |
| Journal | Blood Advances |
| Volume | 2 |
| Issue number | 14 |
| DOIs | |
| State | Published - Jul 24 2018 |
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ASJC Scopus subject areas
- Hematology
Cite this
The use of immunosuppressive therapy in MDS : Clinical outcomes and their predictors in a large international patient cohort. / Stahl, Maximilian; DeVeaux, Michelle; De Witte, Theo; Neukirchen, Judith; Sekeres, Mikkael A.; Brunner, Andrew M.; Roboz, Gail J.; Steensma, David P.; Bhatt, Vijaya R.; Platzbecker, Uwe; Cluzeau, Thomas; Prata, Pedro H.; Itzykson, Raphaël; Fenaux, Pierre; Fathi, Amir T.; Smith, Alexandra; Germing, Ulrich; Ritchie, Ellen K.; Verma, Vivek; Nazha, Aziz; Maciejewski, Jaroslaw P.; Podoltsev, Nikolai A.; Prebet, Thomas; Santini, Valeria; Gore, Steven D.; Komrokji, Rami S.; Zeidan, Amer M.
In: Blood Advances, Vol. 2, No. 14, 24.07.2018, p. 1765-1772.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of immunosuppressive therapy in MDS
T2 - Clinical outcomes and their predictors in a large international patient cohort
AU - Stahl, Maximilian
AU - DeVeaux, Michelle
AU - De Witte, Theo
AU - Neukirchen, Judith
AU - Sekeres, Mikkael A.
AU - Brunner, Andrew M.
AU - Roboz, Gail J.
AU - Steensma, David P.
AU - Bhatt, Vijaya R.
AU - Platzbecker, Uwe
AU - Cluzeau, Thomas
AU - Prata, Pedro H.
AU - Itzykson, Raphaël
AU - Fenaux, Pierre
AU - Fathi, Amir T.
AU - Smith, Alexandra
AU - Germing, Ulrich
AU - Ritchie, Ellen K.
AU - Verma, Vivek
AU - Nazha, Aziz
AU - Maciejewski, Jaroslaw P.
AU - Podoltsev, Nikolai A.
AU - Prebet, Thomas
AU - Santini, Valeria
AU - Gore, Steven D.
AU - Komrokji, Rami S.
AU - Zeidan, Amer M.
PY - 2018/7/24
Y1 - 2018/7/24
N2 - Most studies of immunosuppressive therapy (IST) in myelodysplastic syndromes (MDS) are limited by small numbers and their single-center nature, and report conflicting data regarding predictors for response to IST.We examined outcomes associated with IST and predictors of benefit in a large international cohort of patientswith MDS. Datawere collected from 15 centers in the United States and Europe. Responses, including red blood cell (RBC) transfusion independence (TI), were assessed based on the 2006MDS InternationalWorking Group criteria, and overall survival (OS) was estimated by Kaplan-Meier methods. Logistic regression models estimated odds for response and TI, and Cox Proportional Hazard models estimated hazards ratios forOS.Weidentified 207patientswithMDSreceiving IST, excluding steroidmonotherapy. Themost common IST regimen was anti-thymocyte globulin (ATG) plus prednisone (43%). Overall response rate (ORR) was 48.8%, including 11.2% (95% confidence interval [CI], 6.5%-18.4%)who achieved a complete remission and 30% (95% CI, 22.3%-39.5%) who achieved RBC TI. Median OS was 47.4 months (95% CI, 37-72.3 months) and was longer for patients who achieved a response or TI. Achievement of RBC TI was associated with a hypocellular bone marrow(cellularity, 20%); horse ATG plus cyclosporinewas more effective than rabbit ATG or ATG without cyclosporine. Age, transfusion dependence, presence of paroxysmal nocturnal hemoglobinuria or large granular lymphocyte clones, and HLA DR15 positivity did not predict response to IST. IST leads to objective responses in nearly half the selected patients with the highest rate of RBC TI achieved in patients with hypocellular bone marrows.
AB - Most studies of immunosuppressive therapy (IST) in myelodysplastic syndromes (MDS) are limited by small numbers and their single-center nature, and report conflicting data regarding predictors for response to IST.We examined outcomes associated with IST and predictors of benefit in a large international cohort of patientswith MDS. Datawere collected from 15 centers in the United States and Europe. Responses, including red blood cell (RBC) transfusion independence (TI), were assessed based on the 2006MDS InternationalWorking Group criteria, and overall survival (OS) was estimated by Kaplan-Meier methods. Logistic regression models estimated odds for response and TI, and Cox Proportional Hazard models estimated hazards ratios forOS.Weidentified 207patientswithMDSreceiving IST, excluding steroidmonotherapy. Themost common IST regimen was anti-thymocyte globulin (ATG) plus prednisone (43%). Overall response rate (ORR) was 48.8%, including 11.2% (95% confidence interval [CI], 6.5%-18.4%)who achieved a complete remission and 30% (95% CI, 22.3%-39.5%) who achieved RBC TI. Median OS was 47.4 months (95% CI, 37-72.3 months) and was longer for patients who achieved a response or TI. Achievement of RBC TI was associated with a hypocellular bone marrow(cellularity, 20%); horse ATG plus cyclosporinewas more effective than rabbit ATG or ATG without cyclosporine. Age, transfusion dependence, presence of paroxysmal nocturnal hemoglobinuria or large granular lymphocyte clones, and HLA DR15 positivity did not predict response to IST. IST leads to objective responses in nearly half the selected patients with the highest rate of RBC TI achieved in patients with hypocellular bone marrows.
UR - http://www.scopus.com/inward/record.url?scp=85072746246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85072746246&partnerID=8YFLogxK
U2 - 10.1182/bloodadvances.2018019414
DO - 10.1182/bloodadvances.2018019414
M3 - Article
C2 - 30037803
AN - SCOPUS:85072746246
VL - 2
SP - 1765
EP - 1772
JO - Blood advances
JF - Blood advances
SN - 2473-9529
IS - 14
ER -