The use of 5% mafenide acetate solution in the postgraft treatment of necrotizing fasciitis

E. C. Heinle, W. R. Dougherty, W. L. Garner, D. A. Reilly

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Twenty-nine patients with necrotizing fasciitis who were treated with 5% mafenide acetate solution (MAS) as an adjunct after grafting were compared with 45 patients treated without MAS. Statistical analysis of differences was obtained through P values by X2 testing. The MAS+ (M) and MAS- (C) groups were similar in percent skin deficit (M = 7.5%; C = 9.8%), with the extremity being the most common area of infection. Streptococcus was the most common single organism but polymicrobial infections were the most prevalent (M = 48%; C = 58%). Patients with necrotizing fasciitis treated with MAS had fewer debridements per patient (M = 3.7; C = 5.4), fewer closure procedures (average per patient: M = 1.2; C = 1.73) and a higher percent of first-time closures (83 vs 59%; X2 = 4.26; P = 0.039). There is a trend toward a lower mortality rate (3.4 vs 13%; X2 = 2.00; P = 0.158). We conclude that MAS is a useful adjunct in necrotizing fasciitis wound care protocols.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalJournal of Burn Care and Rehabilitation
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2001

Fingerprint

Mafenide
Necrotizing Fasciitis
Therapeutics
Debridement
Streptococcus
Coinfection
Extremities
Skin
Mortality
Wounds and Injuries
Infection

ASJC Scopus subject areas

  • Surgery
  • Nursing(all)
  • Emergency Medicine
  • Rehabilitation
  • Health Professions(all)

Cite this

The use of 5% mafenide acetate solution in the postgraft treatment of necrotizing fasciitis. / Heinle, E. C.; Dougherty, W. R.; Garner, W. L.; Reilly, D. A.

In: Journal of Burn Care and Rehabilitation, Vol. 22, No. 1, 01.01.2001, p. 35-40.

Research output: Contribution to journalArticle

@article{03e95c08f48246f0af6c2dad5a090fab,
title = "The use of 5{\%} mafenide acetate solution in the postgraft treatment of necrotizing fasciitis",
abstract = "Twenty-nine patients with necrotizing fasciitis who were treated with 5{\%} mafenide acetate solution (MAS) as an adjunct after grafting were compared with 45 patients treated without MAS. Statistical analysis of differences was obtained through P values by X2 testing. The MAS+ (M) and MAS- (C) groups were similar in percent skin deficit (M = 7.5{\%}; C = 9.8{\%}), with the extremity being the most common area of infection. Streptococcus was the most common single organism but polymicrobial infections were the most prevalent (M = 48{\%}; C = 58{\%}). Patients with necrotizing fasciitis treated with MAS had fewer debridements per patient (M = 3.7; C = 5.4), fewer closure procedures (average per patient: M = 1.2; C = 1.73) and a higher percent of first-time closures (83 vs 59{\%}; X2 = 4.26; P = 0.039). There is a trend toward a lower mortality rate (3.4 vs 13{\%}; X2 = 2.00; P = 0.158). We conclude that MAS is a useful adjunct in necrotizing fasciitis wound care protocols.",
author = "Heinle, {E. C.} and Dougherty, {W. R.} and Garner, {W. L.} and Reilly, {D. A.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1097/00004630-200101000-00008",
language = "English (US)",
volume = "22",
pages = "35--40",
journal = "Journal of Burn Care and Research",
issn = "1559-047X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - The use of 5% mafenide acetate solution in the postgraft treatment of necrotizing fasciitis

AU - Heinle, E. C.

AU - Dougherty, W. R.

AU - Garner, W. L.

AU - Reilly, D. A.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Twenty-nine patients with necrotizing fasciitis who were treated with 5% mafenide acetate solution (MAS) as an adjunct after grafting were compared with 45 patients treated without MAS. Statistical analysis of differences was obtained through P values by X2 testing. The MAS+ (M) and MAS- (C) groups were similar in percent skin deficit (M = 7.5%; C = 9.8%), with the extremity being the most common area of infection. Streptococcus was the most common single organism but polymicrobial infections were the most prevalent (M = 48%; C = 58%). Patients with necrotizing fasciitis treated with MAS had fewer debridements per patient (M = 3.7; C = 5.4), fewer closure procedures (average per patient: M = 1.2; C = 1.73) and a higher percent of first-time closures (83 vs 59%; X2 = 4.26; P = 0.039). There is a trend toward a lower mortality rate (3.4 vs 13%; X2 = 2.00; P = 0.158). We conclude that MAS is a useful adjunct in necrotizing fasciitis wound care protocols.

AB - Twenty-nine patients with necrotizing fasciitis who were treated with 5% mafenide acetate solution (MAS) as an adjunct after grafting were compared with 45 patients treated without MAS. Statistical analysis of differences was obtained through P values by X2 testing. The MAS+ (M) and MAS- (C) groups were similar in percent skin deficit (M = 7.5%; C = 9.8%), with the extremity being the most common area of infection. Streptococcus was the most common single organism but polymicrobial infections were the most prevalent (M = 48%; C = 58%). Patients with necrotizing fasciitis treated with MAS had fewer debridements per patient (M = 3.7; C = 5.4), fewer closure procedures (average per patient: M = 1.2; C = 1.73) and a higher percent of first-time closures (83 vs 59%; X2 = 4.26; P = 0.039). There is a trend toward a lower mortality rate (3.4 vs 13%; X2 = 2.00; P = 0.158). We conclude that MAS is a useful adjunct in necrotizing fasciitis wound care protocols.

UR - http://www.scopus.com/inward/record.url?scp=0035133853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035133853&partnerID=8YFLogxK

U2 - 10.1097/00004630-200101000-00008

DO - 10.1097/00004630-200101000-00008

M3 - Article

C2 - 11227682

AN - SCOPUS:0035133853

VL - 22

SP - 35

EP - 40

JO - Journal of Burn Care and Research

JF - Journal of Burn Care and Research

SN - 1559-047X

IS - 1

ER -