The Transport of Urate in Frog Gastric Mucosa

S. C. Sansom, Y. J. Kuo, L. L. Shanbour, E. J. Weinman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The mechanism for the transport of urate was examined using the gastric mucosa of the frog. After short circuiting the tissue to zero potential, both the unidirectional serosal to mucosal and the mucosal to serosal flux of urate were found to be a direct function of the initial concentration of urate. The serosal to mucosal permeability coefficient averaged 6.5 ± 0.8 × 10−10 cm/sec; a value not different from the mucosal to serosal permeability coefficient of 7.7 ± 0.8 × 10−10 cm/sec. These results suggest that urate passes through the gastric mucosa by passive diffusion only. When compared to the small intestine and proximal tubule of the rat the permeability coefficient for urate is significantly lower. Though the gastrointestinal tract is a potential route for the elimination of uric acid, the stomach does not appear to play a major role.

Original languageEnglish (US)
Pages (from-to)363-366
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume170
Issue number3
DOIs
StatePublished - Jul 1982

Fingerprint

Gastric Mucosa
Uric Acid
Anura
Hydraulic conductivity
Permeability
Small Intestine
Gastrointestinal Tract
Mucous Membrane
Rats
Stomach
Tissue
Fluxes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The Transport of Urate in Frog Gastric Mucosa. / Sansom, S. C.; Kuo, Y. J.; Shanbour, L. L.; Weinman, E. J.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 170, No. 3, 07.1982, p. 363-366.

Research output: Contribution to journalArticle

Sansom, S. C. ; Kuo, Y. J. ; Shanbour, L. L. ; Weinman, E. J. / The Transport of Urate in Frog Gastric Mucosa. In: Proceedings of the Society for Experimental Biology and Medicine. 1982 ; Vol. 170, No. 3. pp. 363-366.
@article{e51203055f294fd38fcf2b7d012f72a5,
title = "The Transport of Urate in Frog Gastric Mucosa",
abstract = "The mechanism for the transport of urate was examined using the gastric mucosa of the frog. After short circuiting the tissue to zero potential, both the unidirectional serosal to mucosal and the mucosal to serosal flux of urate were found to be a direct function of the initial concentration of urate. The serosal to mucosal permeability coefficient averaged 6.5 ± 0.8 × 10−10 cm/sec; a value not different from the mucosal to serosal permeability coefficient of 7.7 ± 0.8 × 10−10 cm/sec. These results suggest that urate passes through the gastric mucosa by passive diffusion only. When compared to the small intestine and proximal tubule of the rat the permeability coefficient for urate is significantly lower. Though the gastrointestinal tract is a potential route for the elimination of uric acid, the stomach does not appear to play a major role.",
author = "Sansom, {S. C.} and Kuo, {Y. J.} and Shanbour, {L. L.} and Weinman, {E. J.}",
year = "1982",
month = "7",
doi = "10.3181/00379727-170-41443",
language = "English (US)",
volume = "170",
pages = "363--366",
journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",
issn = "1535-3702",
publisher = "Society for Experimental Biology and Medicine",
number = "3",

}

TY - JOUR

T1 - The Transport of Urate in Frog Gastric Mucosa

AU - Sansom, S. C.

AU - Kuo, Y. J.

AU - Shanbour, L. L.

AU - Weinman, E. J.

PY - 1982/7

Y1 - 1982/7

N2 - The mechanism for the transport of urate was examined using the gastric mucosa of the frog. After short circuiting the tissue to zero potential, both the unidirectional serosal to mucosal and the mucosal to serosal flux of urate were found to be a direct function of the initial concentration of urate. The serosal to mucosal permeability coefficient averaged 6.5 ± 0.8 × 10−10 cm/sec; a value not different from the mucosal to serosal permeability coefficient of 7.7 ± 0.8 × 10−10 cm/sec. These results suggest that urate passes through the gastric mucosa by passive diffusion only. When compared to the small intestine and proximal tubule of the rat the permeability coefficient for urate is significantly lower. Though the gastrointestinal tract is a potential route for the elimination of uric acid, the stomach does not appear to play a major role.

AB - The mechanism for the transport of urate was examined using the gastric mucosa of the frog. After short circuiting the tissue to zero potential, both the unidirectional serosal to mucosal and the mucosal to serosal flux of urate were found to be a direct function of the initial concentration of urate. The serosal to mucosal permeability coefficient averaged 6.5 ± 0.8 × 10−10 cm/sec; a value not different from the mucosal to serosal permeability coefficient of 7.7 ± 0.8 × 10−10 cm/sec. These results suggest that urate passes through the gastric mucosa by passive diffusion only. When compared to the small intestine and proximal tubule of the rat the permeability coefficient for urate is significantly lower. Though the gastrointestinal tract is a potential route for the elimination of uric acid, the stomach does not appear to play a major role.

UR - http://www.scopus.com/inward/record.url?scp=0020265799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020265799&partnerID=8YFLogxK

U2 - 10.3181/00379727-170-41443

DO - 10.3181/00379727-170-41443

M3 - Article

C2 - 6979754

AN - SCOPUS:0020265799

VL - 170

SP - 363

EP - 366

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

SN - 1535-3702

IS - 3

ER -