The T4 glycoprotein is a cell-surface receptor for the AIDS virus

J. S. McDougal, P. J. Maddon, A. G. Dalgleish, P. R. Clapham, D. R. Littman, Maurice Godfrey, L. Chess, R. A. Weiss, R. Axel

Research output: Contribution to journalArticle

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Abstract

Taken together, our studies suggest a mechanism of AIDS virus infection that initially involves the specific association of the AIDS virus with T4 molecules on the cell surface. This association does not require additional T-cell-specific molecules and can be demonstrated on both B lymphocytes and epithelial cell lines. The T4-AIDS virus complex is likely to be internalized in endosomes via receptor-mediated endocytosis. The virus can then fuse with the vacuolar membrane, releasing the viral nucleocapsid into the cytoplasm to undergo uncoating. Viral replication does not appear to require the environment of a T lymphocyte because active infection is also observed in human T4+ B lymphocytes and epithelial cell lines. Moreover, the T4 gene is expressed in the brain as well as in lymphocytes, providing an explanation for the dual neurotropic and lymphoctropic character of the virus. In this manner, a T-lymphocyte surface protein thought to be important in mediating effector cell-target cell interactions has been exploited by a human lymphotropic virus to target the AIDS virus specifically to populations of T4+ cells.

Original languageEnglish (US)
Pages (from-to)703-711
Number of pages9
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume51
Issue number2
StatePublished - Dec 1 1986

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Cell Surface Receptors
Viruses
Glycoproteins
HIV
CD4-Positive T-Lymphocytes
T-cells
Lymphocytes
T-Lymphocytes
B-Lymphocytes
Epithelial Cells
Cell Line
Nucleocapsid
Endosomes
Virus Diseases
Endocytosis
Cell Communication
Membrane Proteins
Cytoplasm
Molecules
Electric fuses

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

McDougal, J. S., Maddon, P. J., Dalgleish, A. G., Clapham, P. R., Littman, D. R., Godfrey, M., ... Axel, R. (1986). The T4 glycoprotein is a cell-surface receptor for the AIDS virus. Cold Spring Harbor Symposia on Quantitative Biology, 51(2), 703-711.

The T4 glycoprotein is a cell-surface receptor for the AIDS virus. / McDougal, J. S.; Maddon, P. J.; Dalgleish, A. G.; Clapham, P. R.; Littman, D. R.; Godfrey, Maurice; Chess, L.; Weiss, R. A.; Axel, R.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 51, No. 2, 01.12.1986, p. 703-711.

Research output: Contribution to journalArticle

McDougal, JS, Maddon, PJ, Dalgleish, AG, Clapham, PR, Littman, DR, Godfrey, M, Chess, L, Weiss, RA & Axel, R 1986, 'The T4 glycoprotein is a cell-surface receptor for the AIDS virus', Cold Spring Harbor Symposia on Quantitative Biology, vol. 51, no. 2, pp. 703-711.
McDougal JS, Maddon PJ, Dalgleish AG, Clapham PR, Littman DR, Godfrey M et al. The T4 glycoprotein is a cell-surface receptor for the AIDS virus. Cold Spring Harbor Symposia on Quantitative Biology. 1986 Dec 1;51(2):703-711.
McDougal, J. S. ; Maddon, P. J. ; Dalgleish, A. G. ; Clapham, P. R. ; Littman, D. R. ; Godfrey, Maurice ; Chess, L. ; Weiss, R. A. ; Axel, R. / The T4 glycoprotein is a cell-surface receptor for the AIDS virus. In: Cold Spring Harbor Symposia on Quantitative Biology. 1986 ; Vol. 51, No. 2. pp. 703-711.
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