The t(14;18) and bcl-2 expression are present in a subset of primary cutaneous follicular lymphoma: Association with lower grade

Lyle C. Lawnicki, Dennis D. Weisenburger, Patricia Aoun, Wing C. Chan, Robert S. Wickert, Timothy Charles Greiner

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

According to the European Organization for Research and Treatment of Cancer classification, primary cutaneous follicle center cell lymphoma is not associated with the t(14;18)(q32;q21) and only rarely expresses bcl-2 protein. To further investigate this issue, we evaluated a series of 20 patients (14 men, 6 women) with primary cutaneous follicular lymphoma (PCFL). The presenting skin lesion was located in the head and neck region in 16 of 20 patients. Most cases were grade 2 (6/20) or grade 3 (13/20), and all had a follicular architecture. Immunohistochemical analysis demonstrated bcl-2 expression in 8 cases (40%), and expression was inversely related to the grade. Of 7 grade 1 or 2 cases, 5 (71%) were positive, whereas only 3 (23%) of 13 grade 3 cases were positive for bcl-2. Clonal immunoglobulin heavy chain gene rearrangements were detected in 9 (45%) of 20 cases. In 4 (20%) of 20 cases, we identified the major breakpoint of the t(14;18) by polymerase chain reaction, 3 of which were grade 1 or 2. We conclude that bcl-2 protein expression and the t(14;18) are present in a subset of PCFL, particularly in lower grade cases.

Original languageEnglish (US)
Pages (from-to)765-772
Number of pages8
JournalAmerican journal of clinical pathology
Volume118
Issue number5
DOIs
Publication statusPublished - Nov 1 2002

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Keywords

  • Cutaneous lymphoma
  • Follicular lymphoma
  • Non-Hodgkin lymphoma
  • bcl-2
  • t(14;18)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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