The surgical treatment of Parkinson's disease

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Surgical treatment of Parkinson' s disease (PD) can provide gratifying symptomatic improvements for many individuals who suffer from persistent disabling symptoms despite the best available medical management. Current surgical therapies include ablative techniques (thalamotomy and pallidotomy), augmentative techniques (nondestructive) (deep brain stimulation), and restorative techniques (tissue transplantation and gene therapy). Ablative procedures can provide substantial clinical benefit, but the current trend is toward deep brain stimulation, which can provide similar symptomatic improvement in a nondestructive manner. Restorative techniques, such as tissue transplantation and gene therapy, are exciting but have significant obstacles to overcome before their promise can be realized. Until the underlying pathological defect of PD can be identified and treated, surgical intervention is likely to remain important in the symptomatic treatment of this disabling disease.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalAnnual Review of Medicine
Volume51
DOIs
StatePublished - May 3 2000

Fingerprint

Transplantation (surgical)
Parkinson Disease
Tissue Transplantation
Gene therapy
Deep Brain Stimulation
Cell- and Tissue-Based Therapy
Genetic Therapy
Brain
Pallidotomy
Therapeutics
Defects

Keywords

  • Deep brains stimulation
  • Movement disorder
  • Pallidotomy
  • Thalamotomy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The surgical treatment of Parkinson's disease. / Follett, Kenneth A.

In: Annual Review of Medicine, Vol. 51, 03.05.2000, p. 135-147.

Research output: Contribution to journalReview article

@article{e25553c3dc3046fca60c20c354fb3c05,
title = "The surgical treatment of Parkinson's disease",
abstract = "Surgical treatment of Parkinson' s disease (PD) can provide gratifying symptomatic improvements for many individuals who suffer from persistent disabling symptoms despite the best available medical management. Current surgical therapies include ablative techniques (thalamotomy and pallidotomy), augmentative techniques (nondestructive) (deep brain stimulation), and restorative techniques (tissue transplantation and gene therapy). Ablative procedures can provide substantial clinical benefit, but the current trend is toward deep brain stimulation, which can provide similar symptomatic improvement in a nondestructive manner. Restorative techniques, such as tissue transplantation and gene therapy, are exciting but have significant obstacles to overcome before their promise can be realized. Until the underlying pathological defect of PD can be identified and treated, surgical intervention is likely to remain important in the symptomatic treatment of this disabling disease.",
keywords = "Deep brains stimulation, Movement disorder, Pallidotomy, Thalamotomy",
author = "Follett, {Kenneth A}",
year = "2000",
month = "5",
day = "3",
doi = "10.1146/annurev.med.51.1.135",
language = "English (US)",
volume = "51",
pages = "135--147",
journal = "Annual Review of Medicine",
issn = "0066-4219",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - The surgical treatment of Parkinson's disease

AU - Follett, Kenneth A

PY - 2000/5/3

Y1 - 2000/5/3

N2 - Surgical treatment of Parkinson' s disease (PD) can provide gratifying symptomatic improvements for many individuals who suffer from persistent disabling symptoms despite the best available medical management. Current surgical therapies include ablative techniques (thalamotomy and pallidotomy), augmentative techniques (nondestructive) (deep brain stimulation), and restorative techniques (tissue transplantation and gene therapy). Ablative procedures can provide substantial clinical benefit, but the current trend is toward deep brain stimulation, which can provide similar symptomatic improvement in a nondestructive manner. Restorative techniques, such as tissue transplantation and gene therapy, are exciting but have significant obstacles to overcome before their promise can be realized. Until the underlying pathological defect of PD can be identified and treated, surgical intervention is likely to remain important in the symptomatic treatment of this disabling disease.

AB - Surgical treatment of Parkinson' s disease (PD) can provide gratifying symptomatic improvements for many individuals who suffer from persistent disabling symptoms despite the best available medical management. Current surgical therapies include ablative techniques (thalamotomy and pallidotomy), augmentative techniques (nondestructive) (deep brain stimulation), and restorative techniques (tissue transplantation and gene therapy). Ablative procedures can provide substantial clinical benefit, but the current trend is toward deep brain stimulation, which can provide similar symptomatic improvement in a nondestructive manner. Restorative techniques, such as tissue transplantation and gene therapy, are exciting but have significant obstacles to overcome before their promise can be realized. Until the underlying pathological defect of PD can be identified and treated, surgical intervention is likely to remain important in the symptomatic treatment of this disabling disease.

KW - Deep brains stimulation

KW - Movement disorder

KW - Pallidotomy

KW - Thalamotomy

UR - http://www.scopus.com/inward/record.url?scp=0034051040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034051040&partnerID=8YFLogxK

U2 - 10.1146/annurev.med.51.1.135

DO - 10.1146/annurev.med.51.1.135

M3 - Review article

VL - 51

SP - 135

EP - 147

JO - Annual Review of Medicine

JF - Annual Review of Medicine

SN - 0066-4219

ER -