The study of the effect of human chorionic gonadotrophic (HCG) hormone on the survival of adrenal medulla transplant in brain. Preliminary study

Arun-Angelo Patil, K. Fillmore, J. Valentine, D. Hill

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Autologous adrenal cortex was completely dissected off the medula using microdissection. The adrenal medulla tissue was transplanted to the lateral ventricle in twenty-one adult rats. Group A consisting of ten animals received 200 units of HCG per 100 gram body weight daily for one week and then on every alternate day for seven weeks. The remaining rats (group B) served as control. After eight weeks the brains were removed and a volumetric study was done using histological sections. High pressure liquid chromatography (HPLC) with electrochemical detection for catecholamine assay of the graft was also undertaken. The graft survival in group A was significantly higher (p<0.005) than group B. The level of norepinephrine was significantly higher in group A while dopamine was higher in group B. The higher volume of graft tissue in group A suggests that HCG may help in increased survival and growth of the transplanted tissue. Higher levels of norepinephrine in group A would suggest a tendency for such grafts to be active to a greater extent with the treatment of HCG.

Original languageEnglish (US)
Pages (from-to)76-78
Number of pages3
JournalActa Neurochirurgica
Volume87
Issue number1-2
DOIs
StatePublished - Aug 1 1987

Fingerprint

Adrenal Medulla
Hormones
Transplants
Norepinephrine
Brain
Microdissection
Lateral Ventricles
Adrenal Cortex
Graft Survival
Catecholamines
Dopamine
High Pressure Liquid Chromatography
Body Weight
Survival
Growth

Keywords

  • Adrenal medulla
  • CNS transplantation
  • catecholamine
  • human chorionic gonadotrophic hormone
  • transplant

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

The study of the effect of human chorionic gonadotrophic (HCG) hormone on the survival of adrenal medulla transplant in brain. Preliminary study. / Patil, Arun-Angelo; Fillmore, K.; Valentine, J.; Hill, D.

In: Acta Neurochirurgica, Vol. 87, No. 1-2, 01.08.1987, p. 76-78.

Research output: Contribution to journalArticle

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