The spectrum of Pneumocystis carinii infection after liver transplantation in children

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Abstract

We report the experience with Pneumocystis carinii lung infections in the 109 children undergoing liver transplantation at our hospital between August, 1985 and May, 1989. PCP developed in 9 of the 86 patients (10%) surviving ≥6 weeks after transplantation and not receiving P carinii chemoprophylaxis. Of the 59 patients undergoing BAL 2 or more weeks after transplantation there were 16 specimens from 14 patients (24%) positive for P carinii. These patients had a spectrum of illness ranging from asymptomatic to severe pneumonia requiring mechanical ventilation. The mean interval from first transplantation to bronchoalveolar lavage positive for P carinii was 24.9 weeks and the mean interval to first PCP was 28.0 weeks. The earliest and latest occurrences of PCP were 7 weeks and 73 weeks, respectively, after transplantation. There were no complications attributed to BAL.

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalTransplantation
Volume54
Issue number4
StatePublished - Oct 1992

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Pneumocystis Infections
Liver Transplantation
Transplantation
Dimercaprol
Chemoprevention
Bronchoalveolar Lavage
Artificial Respiration
Pneumonia
Lung

ASJC Scopus subject areas

  • Transplantation

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The spectrum of Pneumocystis carinii infection after liver transplantation in children. / Colombo, John Louis; Sammut, Paul Henry; Langnas, Alan Norman; Shaw, B. W.

In: Transplantation, Vol. 54, No. 4, 10.1992, p. 621-624.

Research output: Contribution to journalArticle

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