The spectrum of orbital Rosai-Dorfman disease

Yasaman Mohadjer, John B. Holds, Jack Rootman, Mathew W. Wilson, James W. Gigantelli, Philip L. Custer

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

PURPOSE: To describe the spectrum and treatment of orbital Rosai-Dorfman disease and to review previously documented cases. METHODS: Retrospective, interventional case series of seven patients and literature review. RESULTS: Each patient with Rosai-Dorfman disease had unique disease expression requiring aggressive therapy, such as chemotherapy, radiation, and/or surgical excision. One systemically aggressive case presented with intraocular and choroidal invasion, a previously unreported finding. Response to therapy was variable and unpredictable. CONCLUSIONS: Rosai-Dorfman disease, although historically described as benign and self-limiting, may cause significant morbidity and mortality involving multiple organ systems. Available treatment options may not control the disease. Further research and long-term clinical correlation is necessary.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalOphthalmic Plastic and Reconstructive Surgery
Volume22
Issue number3
DOIs
StatePublished - May 1 2006

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ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Mohadjer, Y., Holds, J. B., Rootman, J., Wilson, M. W., Gigantelli, J. W., & Custer, P. L. (2006). The spectrum of orbital Rosai-Dorfman disease. Ophthalmic Plastic and Reconstructive Surgery, 22(3), 163-168. https://doi.org/10.1097/01.iop.0000217563.00975.a3

The spectrum of orbital Rosai-Dorfman disease. / Mohadjer, Yasaman; Holds, John B.; Rootman, Jack; Wilson, Mathew W.; Gigantelli, James W.; Custer, Philip L.

In: Ophthalmic Plastic and Reconstructive Surgery, Vol. 22, No. 3, 01.05.2006, p. 163-168.

Research output: Contribution to journalArticle

Mohadjer, Y, Holds, JB, Rootman, J, Wilson, MW, Gigantelli, JW & Custer, PL 2006, 'The spectrum of orbital Rosai-Dorfman disease', Ophthalmic Plastic and Reconstructive Surgery, vol. 22, no. 3, pp. 163-168. https://doi.org/10.1097/01.iop.0000217563.00975.a3
Mohadjer Y, Holds JB, Rootman J, Wilson MW, Gigantelli JW, Custer PL. The spectrum of orbital Rosai-Dorfman disease. Ophthalmic Plastic and Reconstructive Surgery. 2006 May 1;22(3):163-168. https://doi.org/10.1097/01.iop.0000217563.00975.a3
Mohadjer, Yasaman ; Holds, John B. ; Rootman, Jack ; Wilson, Mathew W. ; Gigantelli, James W. ; Custer, Philip L. / The spectrum of orbital Rosai-Dorfman disease. In: Ophthalmic Plastic and Reconstructive Surgery. 2006 ; Vol. 22, No. 3. pp. 163-168.
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