Abstract
The diagnostic classification of small round blue cell tumors of the sinonasal area to include diverse malignancies of epithelial, hematolymphoid, neuroectodermal, and mesenchymal origin is challenging to the surgical pathologist using conventional histopathologic approaches because the cytomorphologic features are often overlapping or indistinctive. Rare or occasional clinical presentations in atypical age groups or unusual locations, as well as small biopsy samples may further complicate the differential diagnosis. Immunohistochemistry represents an extensively investigated ancillary technique that may aid in the provision of a definitive diagnosis. In recent years, certain small round blue cell tumors have been shown by cytogenetic analysis to have specific and primary chromosomal alterations, providing clinicians with a valuable tool to enhance their diagnostic armamentarium. The addition of molecular cytogenetic [fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH)] and molecular pathologic [polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR] approaches has further enhanced the sensitivity and accuracy of detecting these genetic alterations including assessment in formalin-fixed, paraffin-embedded tissues. Establishing an accurate diagnosis of a small round blue cell tumor of the sinonasal tract frequently requires adjunctive studies including immunohistochemical and molecular analyses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-93 |
| Number of pages | 10 |
| Journal | Head and Neck Pathology |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 2010 |
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Keywords
- Ewing's sarcoma
- Olfactory neuroblastoma
- Rhabdomyosarcoma
- Sinonasal undifferentiated carcinoma
- Small round cell tumor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Otorhinolaryngology
- Oncology
Cite this
The small round blue cell tumors of the sinonasal area. / Bridge, Julia A.; Bowen, Joslin M.; Smith, Russell B.
In: Head and Neck Pathology, Vol. 4, No. 1, 01.03.2010, p. 84-93.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The small round blue cell tumors of the sinonasal area
AU - Bridge, Julia A.
AU - Bowen, Joslin M.
AU - Smith, Russell B.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - The diagnostic classification of small round blue cell tumors of the sinonasal area to include diverse malignancies of epithelial, hematolymphoid, neuroectodermal, and mesenchymal origin is challenging to the surgical pathologist using conventional histopathologic approaches because the cytomorphologic features are often overlapping or indistinctive. Rare or occasional clinical presentations in atypical age groups or unusual locations, as well as small biopsy samples may further complicate the differential diagnosis. Immunohistochemistry represents an extensively investigated ancillary technique that may aid in the provision of a definitive diagnosis. In recent years, certain small round blue cell tumors have been shown by cytogenetic analysis to have specific and primary chromosomal alterations, providing clinicians with a valuable tool to enhance their diagnostic armamentarium. The addition of molecular cytogenetic [fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH)] and molecular pathologic [polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR] approaches has further enhanced the sensitivity and accuracy of detecting these genetic alterations including assessment in formalin-fixed, paraffin-embedded tissues. Establishing an accurate diagnosis of a small round blue cell tumor of the sinonasal tract frequently requires adjunctive studies including immunohistochemical and molecular analyses.
AB - The diagnostic classification of small round blue cell tumors of the sinonasal area to include diverse malignancies of epithelial, hematolymphoid, neuroectodermal, and mesenchymal origin is challenging to the surgical pathologist using conventional histopathologic approaches because the cytomorphologic features are often overlapping or indistinctive. Rare or occasional clinical presentations in atypical age groups or unusual locations, as well as small biopsy samples may further complicate the differential diagnosis. Immunohistochemistry represents an extensively investigated ancillary technique that may aid in the provision of a definitive diagnosis. In recent years, certain small round blue cell tumors have been shown by cytogenetic analysis to have specific and primary chromosomal alterations, providing clinicians with a valuable tool to enhance their diagnostic armamentarium. The addition of molecular cytogenetic [fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH)] and molecular pathologic [polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR] approaches has further enhanced the sensitivity and accuracy of detecting these genetic alterations including assessment in formalin-fixed, paraffin-embedded tissues. Establishing an accurate diagnosis of a small round blue cell tumor of the sinonasal tract frequently requires adjunctive studies including immunohistochemical and molecular analyses.
KW - Ewing's sarcoma
KW - Olfactory neuroblastoma
KW - Rhabdomyosarcoma
KW - Sinonasal undifferentiated carcinoma
KW - Small round cell tumor
UR - http://www.scopus.com/inward/record.url?scp=77952886540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952886540&partnerID=8YFLogxK
U2 - 10.1007/s12105-009-0158-6
DO - 10.1007/s12105-009-0158-6
M3 - Article
C2 - 20237994
AN - SCOPUS:77952886540
VL - 4
SP - 84
EP - 93
JO - Head and Neck Pathology
JF - Head and Neck Pathology
SN - 1936-055X
IS - 1
ER -