The small round blue cell tumors of the sinonasal area

Julia A. Bridge, Joslin M. Bowen, Russell B. Smith

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The diagnostic classification of small round blue cell tumors of the sinonasal area to include diverse malignancies of epithelial, hematolymphoid, neuroectodermal, and mesenchymal origin is challenging to the surgical pathologist using conventional histopathologic approaches because the cytomorphologic features are often overlapping or indistinctive. Rare or occasional clinical presentations in atypical age groups or unusual locations, as well as small biopsy samples may further complicate the differential diagnosis. Immunohistochemistry represents an extensively investigated ancillary technique that may aid in the provision of a definitive diagnosis. In recent years, certain small round blue cell tumors have been shown by cytogenetic analysis to have specific and primary chromosomal alterations, providing clinicians with a valuable tool to enhance their diagnostic armamentarium. The addition of molecular cytogenetic [fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH)] and molecular pathologic [polymerase chain reaction (PCR) and reverse transcriptase (RT)-PCR] approaches has further enhanced the sensitivity and accuracy of detecting these genetic alterations including assessment in formalin-fixed, paraffin-embedded tissues. Establishing an accurate diagnosis of a small round blue cell tumor of the sinonasal tract frequently requires adjunctive studies including immunohistochemical and molecular analyses.

Original languageEnglish (US)
Pages (from-to)84-93
Number of pages10
JournalHead and Neck Pathology
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2010

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Neoplasms
Comparative Genomic Hybridization
Cytogenetic Analysis
Reverse Transcriptase Polymerase Chain Reaction
Fluorescence In Situ Hybridization
Cytogenetics
Paraffin
Formaldehyde
Differential Diagnosis
Age Groups
Immunohistochemistry
Biopsy
Polymerase Chain Reaction
Pathologists

Keywords

  • Ewing's sarcoma
  • Olfactory neuroblastoma
  • Rhabdomyosarcoma
  • Sinonasal undifferentiated carcinoma
  • Small round cell tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

Cite this

The small round blue cell tumors of the sinonasal area. / Bridge, Julia A.; Bowen, Joslin M.; Smith, Russell B.

In: Head and Neck Pathology, Vol. 4, No. 1, 01.03.2010, p. 84-93.

Research output: Contribution to journalArticle

Bridge, Julia A. ; Bowen, Joslin M. ; Smith, Russell B. / The small round blue cell tumors of the sinonasal area. In: Head and Neck Pathology. 2010 ; Vol. 4, No. 1. pp. 84-93.
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