The significance of lamina propria invasion on the prognosis of patients with bladder tumors

C. Anderstrom, S. Johansson, S. Nilsson

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

We reviewed 177 patients with superficial bladder tumors. The prognosis for 78 patients with non-invasive grades 1 to 3 tumors was excellent regardless of treatment. In 99 patients with tumors infiltrating the lamina propria the 5 and 10-year survival rates were 71 and 64 per cent, respectively. The prognosis of patients with grades 2 and 3 tumors infiltrating the lamina propria submitted to transurethral resection or cystectomy was excellent. In contrast, the prognosis was poor among patients with signs of tumor invasion of the lymphatic vessels of the lamina propria and patients undergoing transurethral resection and supervoltage irradiation. Our study indicates that patients with grades 1 to 3 bladder tumors, which are confined to the mucosa or do not infiltrate deeper than into the lamina propria should, if possible, be managed by transurethral resection. However, if lymphatic invasion is present the patient does not seem to benefit from an operation alone. Thus, the combined treatment of supervoltage irradiation and an extensive operation may be considered in these patients.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalJournal of Urology
Volume124
Issue number1
DOIs
StatePublished - Jan 1 1980

Fingerprint

Urinary Bladder Neoplasms
Mucous Membrane
Lymphatic Vessel Tumors
Neoplasms
Cystectomy
Survival Rate
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

The significance of lamina propria invasion on the prognosis of patients with bladder tumors. / Anderstrom, C.; Johansson, S.; Nilsson, S.

In: Journal of Urology, Vol. 124, No. 1, 01.01.1980, p. 23-26.

Research output: Contribution to journalArticle

Anderstrom, C. ; Johansson, S. ; Nilsson, S. / The significance of lamina propria invasion on the prognosis of patients with bladder tumors. In: Journal of Urology. 1980 ; Vol. 124, No. 1. pp. 23-26.
@article{8946117e68c34aaa87a615ef8983aa84,
title = "The significance of lamina propria invasion on the prognosis of patients with bladder tumors",
abstract = "We reviewed 177 patients with superficial bladder tumors. The prognosis for 78 patients with non-invasive grades 1 to 3 tumors was excellent regardless of treatment. In 99 patients with tumors infiltrating the lamina propria the 5 and 10-year survival rates were 71 and 64 per cent, respectively. The prognosis of patients with grades 2 and 3 tumors infiltrating the lamina propria submitted to transurethral resection or cystectomy was excellent. In contrast, the prognosis was poor among patients with signs of tumor invasion of the lymphatic vessels of the lamina propria and patients undergoing transurethral resection and supervoltage irradiation. Our study indicates that patients with grades 1 to 3 bladder tumors, which are confined to the mucosa or do not infiltrate deeper than into the lamina propria should, if possible, be managed by transurethral resection. However, if lymphatic invasion is present the patient does not seem to benefit from an operation alone. Thus, the combined treatment of supervoltage irradiation and an extensive operation may be considered in these patients.",
author = "C. Anderstrom and S. Johansson and S. Nilsson",
year = "1980",
month = "1",
day = "1",
doi = "10.1016/S0022-5347(17)55272-6",
language = "English (US)",
volume = "124",
pages = "23--26",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - The significance of lamina propria invasion on the prognosis of patients with bladder tumors

AU - Anderstrom, C.

AU - Johansson, S.

AU - Nilsson, S.

PY - 1980/1/1

Y1 - 1980/1/1

N2 - We reviewed 177 patients with superficial bladder tumors. The prognosis for 78 patients with non-invasive grades 1 to 3 tumors was excellent regardless of treatment. In 99 patients with tumors infiltrating the lamina propria the 5 and 10-year survival rates were 71 and 64 per cent, respectively. The prognosis of patients with grades 2 and 3 tumors infiltrating the lamina propria submitted to transurethral resection or cystectomy was excellent. In contrast, the prognosis was poor among patients with signs of tumor invasion of the lymphatic vessels of the lamina propria and patients undergoing transurethral resection and supervoltage irradiation. Our study indicates that patients with grades 1 to 3 bladder tumors, which are confined to the mucosa or do not infiltrate deeper than into the lamina propria should, if possible, be managed by transurethral resection. However, if lymphatic invasion is present the patient does not seem to benefit from an operation alone. Thus, the combined treatment of supervoltage irradiation and an extensive operation may be considered in these patients.

AB - We reviewed 177 patients with superficial bladder tumors. The prognosis for 78 patients with non-invasive grades 1 to 3 tumors was excellent regardless of treatment. In 99 patients with tumors infiltrating the lamina propria the 5 and 10-year survival rates were 71 and 64 per cent, respectively. The prognosis of patients with grades 2 and 3 tumors infiltrating the lamina propria submitted to transurethral resection or cystectomy was excellent. In contrast, the prognosis was poor among patients with signs of tumor invasion of the lymphatic vessels of the lamina propria and patients undergoing transurethral resection and supervoltage irradiation. Our study indicates that patients with grades 1 to 3 bladder tumors, which are confined to the mucosa or do not infiltrate deeper than into the lamina propria should, if possible, be managed by transurethral resection. However, if lymphatic invasion is present the patient does not seem to benefit from an operation alone. Thus, the combined treatment of supervoltage irradiation and an extensive operation may be considered in these patients.

UR - http://www.scopus.com/inward/record.url?scp=0018933863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018933863&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(17)55272-6

DO - 10.1016/S0022-5347(17)55272-6

M3 - Article

C2 - 7411714

AN - SCOPUS:0018933863

VL - 124

SP - 23

EP - 26

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -