The safety of intraocular ketorolac in rabbits

Eyal Margalit, Lance J Kugler, Matthew V. Brumm, Jane L Meza, Uday B. Kompella, Edith R. Escobar, Gerald R. Christensen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

PURPOSE. To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS. Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0.1 mL) was injected into the vitreous of the right eye of 15 rabbits. Physiologic saline solution (BSS; Alcon, Ft. Worth, TX) was injected into the left eye of each rabbit as a control. A standard electroretinogram and intraocular pressure measurements were obtained before injection, and repeated 1 day and 1, 2, 3, and 4 weeks after injection. After 4 weeks, the rabbits were euthanatized and the retinas examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure, and histopathology between the two eyes were recorded. Further, the elimination half-life of the drug in the vitreous was assessed. RESULTS. There were no statistically significant differences in electroretinograms, or intraocular pressure measurements obtained between the ketorolac-injected eyes and the control eyes. The half life of the drug was measured to be 2.3 hours. No histopathologic changes were observed in study eyes compared with control eyes. CONCLUSIONS. Preservative-free ketorolac tromethamine is nontoxic to the retinas of rabbits when injected intravitreally and could be considered as an alternative to intraocular steroid injections.

Original languageEnglish (US)
Pages (from-to)2093-2099
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume47
Issue number5
DOIs
StatePublished - May 1 2006

Fingerprint

Ketorolac
Rabbits
Ketorolac Tromethamine
Safety
Intraocular Injections
Intraocular Pressure
Half-Life
Retina
Steroids
Pharmaceutical Preparations
Injections
Ophthalmic Solutions
Sodium Chloride
Electron Microscopy
Anti-Inflammatory Agents
Light

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Margalit, E., Kugler, L. J., Brumm, M. V., Meza, J. L., Kompella, U. B., Escobar, E. R., & Christensen, G. R. (2006). The safety of intraocular ketorolac in rabbits. Investigative Ophthalmology and Visual Science, 47(5), 2093-2099. https://doi.org/10.1167/iovs.05-0764

The safety of intraocular ketorolac in rabbits. / Margalit, Eyal; Kugler, Lance J; Brumm, Matthew V.; Meza, Jane L; Kompella, Uday B.; Escobar, Edith R.; Christensen, Gerald R.

In: Investigative Ophthalmology and Visual Science, Vol. 47, No. 5, 01.05.2006, p. 2093-2099.

Research output: Contribution to journalArticle

Margalit, E, Kugler, LJ, Brumm, MV, Meza, JL, Kompella, UB, Escobar, ER & Christensen, GR 2006, 'The safety of intraocular ketorolac in rabbits', Investigative Ophthalmology and Visual Science, vol. 47, no. 5, pp. 2093-2099. https://doi.org/10.1167/iovs.05-0764
Margalit, Eyal ; Kugler, Lance J ; Brumm, Matthew V. ; Meza, Jane L ; Kompella, Uday B. ; Escobar, Edith R. ; Christensen, Gerald R. / The safety of intraocular ketorolac in rabbits. In: Investigative Ophthalmology and Visual Science. 2006 ; Vol. 47, No. 5. pp. 2093-2099.
@article{b2ed3deefc6f43c1abc3ce1ca2652942,
title = "The safety of intraocular ketorolac in rabbits",
abstract = "PURPOSE. To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS. Either 0.5{\%} or 0.25{\%} preservative-free ketorolac tromethamine ophthalmic solution (0.1 mL) was injected into the vitreous of the right eye of 15 rabbits. Physiologic saline solution (BSS; Alcon, Ft. Worth, TX) was injected into the left eye of each rabbit as a control. A standard electroretinogram and intraocular pressure measurements were obtained before injection, and repeated 1 day and 1, 2, 3, and 4 weeks after injection. After 4 weeks, the rabbits were euthanatized and the retinas examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure, and histopathology between the two eyes were recorded. Further, the elimination half-life of the drug in the vitreous was assessed. RESULTS. There were no statistically significant differences in electroretinograms, or intraocular pressure measurements obtained between the ketorolac-injected eyes and the control eyes. The half life of the drug was measured to be 2.3 hours. No histopathologic changes were observed in study eyes compared with control eyes. CONCLUSIONS. Preservative-free ketorolac tromethamine is nontoxic to the retinas of rabbits when injected intravitreally and could be considered as an alternative to intraocular steroid injections.",
author = "Eyal Margalit and Kugler, {Lance J} and Brumm, {Matthew V.} and Meza, {Jane L} and Kompella, {Uday B.} and Escobar, {Edith R.} and Christensen, {Gerald R.}",
year = "2006",
month = "5",
day = "1",
doi = "10.1167/iovs.05-0764",
language = "English (US)",
volume = "47",
pages = "2093--2099",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "5",

}

TY - JOUR

T1 - The safety of intraocular ketorolac in rabbits

AU - Margalit, Eyal

AU - Kugler, Lance J

AU - Brumm, Matthew V.

AU - Meza, Jane L

AU - Kompella, Uday B.

AU - Escobar, Edith R.

AU - Christensen, Gerald R.

PY - 2006/5/1

Y1 - 2006/5/1

N2 - PURPOSE. To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS. Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0.1 mL) was injected into the vitreous of the right eye of 15 rabbits. Physiologic saline solution (BSS; Alcon, Ft. Worth, TX) was injected into the left eye of each rabbit as a control. A standard electroretinogram and intraocular pressure measurements were obtained before injection, and repeated 1 day and 1, 2, 3, and 4 weeks after injection. After 4 weeks, the rabbits were euthanatized and the retinas examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure, and histopathology between the two eyes were recorded. Further, the elimination half-life of the drug in the vitreous was assessed. RESULTS. There were no statistically significant differences in electroretinograms, or intraocular pressure measurements obtained between the ketorolac-injected eyes and the control eyes. The half life of the drug was measured to be 2.3 hours. No histopathologic changes were observed in study eyes compared with control eyes. CONCLUSIONS. Preservative-free ketorolac tromethamine is nontoxic to the retinas of rabbits when injected intravitreally and could be considered as an alternative to intraocular steroid injections.

AB - PURPOSE. To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS. Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0.1 mL) was injected into the vitreous of the right eye of 15 rabbits. Physiologic saline solution (BSS; Alcon, Ft. Worth, TX) was injected into the left eye of each rabbit as a control. A standard electroretinogram and intraocular pressure measurements were obtained before injection, and repeated 1 day and 1, 2, 3, and 4 weeks after injection. After 4 weeks, the rabbits were euthanatized and the retinas examined by light and electron microscopy. Differences in the electroretinograms, intraocular pressure, and histopathology between the two eyes were recorded. Further, the elimination half-life of the drug in the vitreous was assessed. RESULTS. There were no statistically significant differences in electroretinograms, or intraocular pressure measurements obtained between the ketorolac-injected eyes and the control eyes. The half life of the drug was measured to be 2.3 hours. No histopathologic changes were observed in study eyes compared with control eyes. CONCLUSIONS. Preservative-free ketorolac tromethamine is nontoxic to the retinas of rabbits when injected intravitreally and could be considered as an alternative to intraocular steroid injections.

UR - http://www.scopus.com/inward/record.url?scp=33744724283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33744724283&partnerID=8YFLogxK

U2 - 10.1167/iovs.05-0764

DO - 10.1167/iovs.05-0764

M3 - Article

C2 - 16639020

AN - SCOPUS:33744724283

VL - 47

SP - 2093

EP - 2099

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 5

ER -