Abstract
Although increasing data indicate a role for vitamin D in prostate cancer, little is known about the role of this hormone in the noncancerous prostate. We examined the effect of 1,25-dihydroxyvitamin D3 (1,25 D) on the growth of noncancerous rat prostates in vivo. Rats were castrated and treated with vehicle (controls), 1,25 D, testosterone, or a combination of both hormones for 2 weeks. Histological examination of the harvested prostates revealed that 1,25 D had a selective regressive effect on epithelial cells in treated rats compared to untreated castrated rats and to normal uncastrated rats. However, 1,25 D stimulated stromal growth in the prostate. The mean prostatic weight of the vitamin D-treated rats was twice that of the untreated rats (0.13 ± SEM 0.005 g versus 0.06 ± SEM 0.006 g). The histological differences were less marked in the testosterone-supplemented animals. A greater degree of cellular differentiation was observed in the rats treated with testosterone and vitamin D compared to rats that received testosterone supplementation alone. Studies of the nuclear matrix composition revealed differences between the testosterone-supplemented and the testosterone and 1,25 D-treated rat prostates. We conclude that in the absence of testosterone, 1,25 D may exert a growth-promoting effect on the prostatic stroma in vivo. In concert with testosterone, it may play an important role in the growth and differentiation of the normal rat prostate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1563-1570 |
| Number of pages | 8 |
| Journal | Cell Growth and Differentiation |
| Volume | 7 |
| Issue number | 11 |
| State | Published - Nov 20 1996 |
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
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The role of vitamin D in normal prostate growth and differentiation. / Konety, Badrinath R.; Schwartz, Gary G.; Acierno, James S.; Becich, Michael J.; Getzenberg, Robert H.
In: Cell Growth and Differentiation, Vol. 7, No. 11, 20.11.1996, p. 1563-1570.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of vitamin D in normal prostate growth and differentiation
AU - Konety, Badrinath R.
AU - Schwartz, Gary G.
AU - Acierno, James S.
AU - Becich, Michael J.
AU - Getzenberg, Robert H.
PY - 1996/11/20
Y1 - 1996/11/20
N2 - Although increasing data indicate a role for vitamin D in prostate cancer, little is known about the role of this hormone in the noncancerous prostate. We examined the effect of 1,25-dihydroxyvitamin D3 (1,25 D) on the growth of noncancerous rat prostates in vivo. Rats were castrated and treated with vehicle (controls), 1,25 D, testosterone, or a combination of both hormones for 2 weeks. Histological examination of the harvested prostates revealed that 1,25 D had a selective regressive effect on epithelial cells in treated rats compared to untreated castrated rats and to normal uncastrated rats. However, 1,25 D stimulated stromal growth in the prostate. The mean prostatic weight of the vitamin D-treated rats was twice that of the untreated rats (0.13 ± SEM 0.005 g versus 0.06 ± SEM 0.006 g). The histological differences were less marked in the testosterone-supplemented animals. A greater degree of cellular differentiation was observed in the rats treated with testosterone and vitamin D compared to rats that received testosterone supplementation alone. Studies of the nuclear matrix composition revealed differences between the testosterone-supplemented and the testosterone and 1,25 D-treated rat prostates. We conclude that in the absence of testosterone, 1,25 D may exert a growth-promoting effect on the prostatic stroma in vivo. In concert with testosterone, it may play an important role in the growth and differentiation of the normal rat prostate.
AB - Although increasing data indicate a role for vitamin D in prostate cancer, little is known about the role of this hormone in the noncancerous prostate. We examined the effect of 1,25-dihydroxyvitamin D3 (1,25 D) on the growth of noncancerous rat prostates in vivo. Rats were castrated and treated with vehicle (controls), 1,25 D, testosterone, or a combination of both hormones for 2 weeks. Histological examination of the harvested prostates revealed that 1,25 D had a selective regressive effect on epithelial cells in treated rats compared to untreated castrated rats and to normal uncastrated rats. However, 1,25 D stimulated stromal growth in the prostate. The mean prostatic weight of the vitamin D-treated rats was twice that of the untreated rats (0.13 ± SEM 0.005 g versus 0.06 ± SEM 0.006 g). The histological differences were less marked in the testosterone-supplemented animals. A greater degree of cellular differentiation was observed in the rats treated with testosterone and vitamin D compared to rats that received testosterone supplementation alone. Studies of the nuclear matrix composition revealed differences between the testosterone-supplemented and the testosterone and 1,25 D-treated rat prostates. We conclude that in the absence of testosterone, 1,25 D may exert a growth-promoting effect on the prostatic stroma in vivo. In concert with testosterone, it may play an important role in the growth and differentiation of the normal rat prostate.
UR - http://www.scopus.com/inward/record.url?scp=0029914170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029914170&partnerID=8YFLogxK
M3 - Article
C2 - 8930406
AN - SCOPUS:0029914170
VL - 7
SP - 1563
EP - 1570
JO - Molecular Cancer Research
JF - Molecular Cancer Research
SN - 1541-7786
IS - 11
ER -