The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases.

Yunlong Huang, N. Erdmann, H. Peng, Y. Zhao, Jialin C Zheng

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions, and in many cases neuronal cell death. Although the etiology of neurodegenerative diseases may be distinct, different diseases display a similar pathogenesis, for example abnormal immunity within the central nervous system (CNS), activation of macrophage/microglia and the involvement of proinflammatory cytokines. Recent studies show that neurons in a neurodegenerative state undergo a highly regulated programmed cell death, also called apoptosis. TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, has been shown to be involved in apoptosis during many diseases. As one member of a death ligand family, TRAIL was originally thought to target only tumor cells and was not present in CNS. However, recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages, a major disease inducing cell during HIV-1-associated dementia (HAD). TRAIL is also induced on neuron by beta-amyloid protein, an important pathogen for Alzheimer's disease. In this review, we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases, TRAIL induced apoptosis signaling in the CNS cells, and specific role of TRAIL in individual diseases.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalCellular & molecular immunology
Volume2
Issue number2
StatePublished - Apr 2005

Fingerprint

TNF-Related Apoptosis-Inducing Ligand
Neurodegenerative Diseases
Central Nervous System
Apoptosis
HIV-1
Cell Death
Neurons
Macrophage Activation
Amyloid beta-Peptides
Microglia
Dementia
Immunity
Alzheimer Disease
Macrophages
Cytokines
Ligands

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. / Huang, Yunlong; Erdmann, N.; Peng, H.; Zhao, Y.; Zheng, Jialin C.

In: Cellular & molecular immunology, Vol. 2, No. 2, 04.2005, p. 113-122.

Research output: Contribution to journalReview article

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