The role of specialized pro-resolving mediators in maternal-fetal health

E. Elliott, Corrine K Hanson, Ann L Anderson Berry, T. M. Nordgren

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.

Original languageEnglish (US)
Pages (from-to)98-104
Number of pages7
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume126
DOIs
Publication statusPublished - Nov 2017

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Keywords

  • Docosahexaenoic acid
  • Fetal health
  • Omega-3 fatty acid
  • Pregnancy
  • Pro-resolving lipid mediator
  • Resolvins

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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