The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar

Jennifer F. Thorson, Amy T. Desaulniers, Chanho Lee, Brett R. White, J. Joe Ford, Clay A. Lents

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

RFamide-related peptide 3 (RFRP3) has been implicated in regulating reproduction and growth. This regulation appears to be dependent upon sex, species, physiological status, and developmental stage. The objective of the present study was to evaluate the effects of RFRP3 on circulating concentrations of luteinizing hormone (LH) and growth hormone (GH) in mature boars. The hypothesis was RFRP3 would reduce circulating concentrations of LH and increase concentrations of GH. Meishan boars (716.6. ±. 2.8 days of age 125.0. ±. 12.4. kg BW) were randomly assigned to treatment: saline (. n=. 4) or RFRP3 (8.5. mg; n=. 5). Plasma was collected at 15-min intervals during 3 periods: pre-treatment, treatment, and post-treatment. During the treatment period, saline or RFRP3 were administered at 15-min intervals. Treatment was administered as a loading dose of 5. mg RFRP3, followed by seven repeated injections of 0.5. mg RFRP3. Pulsatile secretion of LH and GH were not affected by saline treatment. Mean concentrations of LH in RFRP3-treated boars were greater (. P<. 0.01) in the pre-treatment period than in the treatment and post-treatment periods; however, the individual response to RFRP3 challenge was varied. RFRP3 suppressed (. P<. 0.05) mean concentrations of GH during the treatment period. It is concluded that RFRP3 can act to suppress LH secretion in some boars, but the minimal and varied response between animals does not strongly support the idea that RFRP3 is a potent hypohysiotropic hormone in the pig. Results indicate that RFRP3 may function in regulating the growth axis of swine.

Original languageEnglish (US)
Pages (from-to)60-65
Number of pages6
JournalAnimal Reproduction Science
Volume159
DOIs
StatePublished - Aug 1 2015

Fingerprint

boars
peptides
Growth
luteinizing hormone
Luteinizing Hormone
somatotropin
Growth Hormone
Therapeutics
RFamide peptide
Swine
pretreatment
Meishan
swine
hormone secretion
physiological state
Reproduction
hormones
developmental stages
secretion
Hormones

Keywords

  • Boar, Growth hormone
  • Luteinizing hormone
  • Neuroendocrinology
  • RFamide-related peptide 3

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

Cite this

The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar. / Thorson, Jennifer F.; Desaulniers, Amy T.; Lee, Chanho; White, Brett R.; Ford, J. Joe; Lents, Clay A.

In: Animal Reproduction Science, Vol. 159, 01.08.2015, p. 60-65.

Research output: Contribution to journalArticle

Thorson, Jennifer F. ; Desaulniers, Amy T. ; Lee, Chanho ; White, Brett R. ; Ford, J. Joe ; Lents, Clay A. / The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar. In: Animal Reproduction Science. 2015 ; Vol. 159. pp. 60-65.
@article{121fa2455f75477ab2d26b98f0765da7,
title = "The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar",
abstract = "RFamide-related peptide 3 (RFRP3) has been implicated in regulating reproduction and growth. This regulation appears to be dependent upon sex, species, physiological status, and developmental stage. The objective of the present study was to evaluate the effects of RFRP3 on circulating concentrations of luteinizing hormone (LH) and growth hormone (GH) in mature boars. The hypothesis was RFRP3 would reduce circulating concentrations of LH and increase concentrations of GH. Meishan boars (716.6. ±. 2.8 days of age 125.0. ±. 12.4. kg BW) were randomly assigned to treatment: saline (. n=. 4) or RFRP3 (8.5. mg; n=. 5). Plasma was collected at 15-min intervals during 3 periods: pre-treatment, treatment, and post-treatment. During the treatment period, saline or RFRP3 were administered at 15-min intervals. Treatment was administered as a loading dose of 5. mg RFRP3, followed by seven repeated injections of 0.5. mg RFRP3. Pulsatile secretion of LH and GH were not affected by saline treatment. Mean concentrations of LH in RFRP3-treated boars were greater (. P<. 0.01) in the pre-treatment period than in the treatment and post-treatment periods; however, the individual response to RFRP3 challenge was varied. RFRP3 suppressed (. P<. 0.05) mean concentrations of GH during the treatment period. It is concluded that RFRP3 can act to suppress LH secretion in some boars, but the minimal and varied response between animals does not strongly support the idea that RFRP3 is a potent hypohysiotropic hormone in the pig. Results indicate that RFRP3 may function in regulating the growth axis of swine.",
keywords = "Boar, Growth hormone, Luteinizing hormone, Neuroendocrinology, RFamide-related peptide 3",
author = "Thorson, {Jennifer F.} and Desaulniers, {Amy T.} and Chanho Lee and White, {Brett R.} and Ford, {J. Joe} and Lents, {Clay A.}",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.anireprosci.2015.05.013",
language = "English (US)",
volume = "159",
pages = "60--65",
journal = "Animal Reproduction Science",
issn = "0378-4320",
publisher = "Elsevier",

}

TY - JOUR

T1 - The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar

AU - Thorson, Jennifer F.

AU - Desaulniers, Amy T.

AU - Lee, Chanho

AU - White, Brett R.

AU - Ford, J. Joe

AU - Lents, Clay A.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - RFamide-related peptide 3 (RFRP3) has been implicated in regulating reproduction and growth. This regulation appears to be dependent upon sex, species, physiological status, and developmental stage. The objective of the present study was to evaluate the effects of RFRP3 on circulating concentrations of luteinizing hormone (LH) and growth hormone (GH) in mature boars. The hypothesis was RFRP3 would reduce circulating concentrations of LH and increase concentrations of GH. Meishan boars (716.6. ±. 2.8 days of age 125.0. ±. 12.4. kg BW) were randomly assigned to treatment: saline (. n=. 4) or RFRP3 (8.5. mg; n=. 5). Plasma was collected at 15-min intervals during 3 periods: pre-treatment, treatment, and post-treatment. During the treatment period, saline or RFRP3 were administered at 15-min intervals. Treatment was administered as a loading dose of 5. mg RFRP3, followed by seven repeated injections of 0.5. mg RFRP3. Pulsatile secretion of LH and GH were not affected by saline treatment. Mean concentrations of LH in RFRP3-treated boars were greater (. P<. 0.01) in the pre-treatment period than in the treatment and post-treatment periods; however, the individual response to RFRP3 challenge was varied. RFRP3 suppressed (. P<. 0.05) mean concentrations of GH during the treatment period. It is concluded that RFRP3 can act to suppress LH secretion in some boars, but the minimal and varied response between animals does not strongly support the idea that RFRP3 is a potent hypohysiotropic hormone in the pig. Results indicate that RFRP3 may function in regulating the growth axis of swine.

AB - RFamide-related peptide 3 (RFRP3) has been implicated in regulating reproduction and growth. This regulation appears to be dependent upon sex, species, physiological status, and developmental stage. The objective of the present study was to evaluate the effects of RFRP3 on circulating concentrations of luteinizing hormone (LH) and growth hormone (GH) in mature boars. The hypothesis was RFRP3 would reduce circulating concentrations of LH and increase concentrations of GH. Meishan boars (716.6. ±. 2.8 days of age 125.0. ±. 12.4. kg BW) were randomly assigned to treatment: saline (. n=. 4) or RFRP3 (8.5. mg; n=. 5). Plasma was collected at 15-min intervals during 3 periods: pre-treatment, treatment, and post-treatment. During the treatment period, saline or RFRP3 were administered at 15-min intervals. Treatment was administered as a loading dose of 5. mg RFRP3, followed by seven repeated injections of 0.5. mg RFRP3. Pulsatile secretion of LH and GH were not affected by saline treatment. Mean concentrations of LH in RFRP3-treated boars were greater (. P<. 0.01) in the pre-treatment period than in the treatment and post-treatment periods; however, the individual response to RFRP3 challenge was varied. RFRP3 suppressed (. P<. 0.05) mean concentrations of GH during the treatment period. It is concluded that RFRP3 can act to suppress LH secretion in some boars, but the minimal and varied response between animals does not strongly support the idea that RFRP3 is a potent hypohysiotropic hormone in the pig. Results indicate that RFRP3 may function in regulating the growth axis of swine.

KW - Boar, Growth hormone

KW - Luteinizing hormone

KW - Neuroendocrinology

KW - RFamide-related peptide 3

UR - http://www.scopus.com/inward/record.url?scp=84937520908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937520908&partnerID=8YFLogxK

U2 - 10.1016/j.anireprosci.2015.05.013

DO - 10.1016/j.anireprosci.2015.05.013

M3 - Article

C2 - 26051609

AN - SCOPUS:84937520908

VL - 159

SP - 60

EP - 65

JO - Animal Reproduction Science

JF - Animal Reproduction Science

SN - 0378-4320

ER -