The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development

Dominique Ziech, Rodrigo Franco-Cruz, Alexandros G. Georgakilas, Stavroula Georgakila, Vasiliki Malamou-Mitsi, Onard Schoneveld, Aglaia Pappa, Mihalis I. Panayiotidis

Research output: Contribution to journalReview article

144 Citations (Scopus)

Abstract

Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation.

Original languageEnglish (US)
Pages (from-to)334-339
Number of pages6
JournalChemico-Biological Interactions
Volume188
Issue number2
DOIs
StatePublished - Nov 1 2010

Fingerprint

Oxidative stress
Biomarkers
Reactive Oxygen Species
Carcinogenesis
Oxidative Stress
Environmental Exposure
Toxicity
Epidemiologic Studies
Lipids
Oxidation
DNA
Proteins

Keywords

  • Biomarkers
  • Environmental carcinogenesis
  • Oxidative DNA damage
  • Oxidative stress
  • ROS

ASJC Scopus subject areas

  • Toxicology

Cite this

The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. / Ziech, Dominique; Franco-Cruz, Rodrigo; Georgakilas, Alexandros G.; Georgakila, Stavroula; Malamou-Mitsi, Vasiliki; Schoneveld, Onard; Pappa, Aglaia; Panayiotidis, Mihalis I.

In: Chemico-Biological Interactions, Vol. 188, No. 2, 01.11.2010, p. 334-339.

Research output: Contribution to journalReview article

Ziech, D, Franco-Cruz, R, Georgakilas, AG, Georgakila, S, Malamou-Mitsi, V, Schoneveld, O, Pappa, A & Panayiotidis, MI 2010, 'The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development', Chemico-Biological Interactions, vol. 188, no. 2, pp. 334-339. https://doi.org/10.1016/j.cbi.2010.07.010
Ziech, Dominique ; Franco-Cruz, Rodrigo ; Georgakilas, Alexandros G. ; Georgakila, Stavroula ; Malamou-Mitsi, Vasiliki ; Schoneveld, Onard ; Pappa, Aglaia ; Panayiotidis, Mihalis I. / The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development. In: Chemico-Biological Interactions. 2010 ; Vol. 188, No. 2. pp. 334-339.
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