The role of parvovirus b19 in aplastic crisis and erythema infectiosum (Fifth disease)

Terence Chorba, Peter Coccia, Robert C. Holman, Peter Tattersall, Larry J. Anderson, Jon Sudman, Neal S. Young, Elizabeth Kurczynski, Ulla M. Saarinen, Robyn Moir, Dale N. Lawrence, Janine M. Jason, Bruce Evatt, Terence Chorba, Peter Coccia, Robert C. Holman, Peter Tattersall, Larry J. Anderson, Jon Sudman, Neal S. YoungElizabeth Kurczynski, Ulla M. Saarinen, Robyn Moir, Dale N. Lawrence, Janine M. Jason, Bruce Evatt, Terence Chorba, Peter Coccia, Robert C. Holman, Peter Tattersall, Larry J. Anderson, Jon Sudman, Neal S. Young, Elizabeth Kurczynski, Ulla M. Saarinen, Robyn Moir, Dale N. Lawrence, Janine M. Jason, Bruce Evatt, Terence Chorba, Peter Coccia, Robert C. Holman, Peter Tattersall, Larry J. Anderson, Jon Sudman, Neal S. Young, Elizabeth Kurczynski, Ulla M. Saarinen, Robyn Moir, Dale N. Lawrence, Janine M. Jason, Bruce Evatt, Terence Chorba, Peter Coccia, Robert C. Holman, Peter Tattersall, Larry J. Anderson, Jon Sudman, Neal S. Young, Elizabeth Kurczynski, Ulla M. Saarinen, Robyn Moir, Dale N. Lawrence, Janine M. Jason, Bruce Evatt

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

In 1984, simultaneous outbreaks of aplastic crisis and erythema infectiosum occurred in northeastern Ohio. Sera were analyzed from 26 patients with aplastic crisis: 24 had IgM specific for parvovirus B19, five had B19-like particles by electron microscopy, and 13 had DNA from B19; no sera from 33 controls had evidence of recent infection with B19 (P<.0001). DNA from B19 was also detected in specimens of throat gargle and urine from two patients with aplastic crisis. Sera from 36 of 51 children with erythema infectiosum had B19-specific IgM, compared with serum from one of 42 susceptible controls (P<.0001). DNA from B19 was detected in sera from only two of 51 patients who had erythema infectiosum. The secondary attack rates among susceptible contacts decreased with age (overall total, 49.6%). Differential rates of asymptomatic infection were observed among black (68.8%) and white (20.0%) household members (P =.003). These were the first identified simultaneous outbreaks of aplastic crisis and erythema infectiosum. Their occurrence provided an opportunity to study the epidemiology and spectrum of B19 infection with geographically and temporally matched comparison groups; our results support the hypothesis that infection with parvovirus causes these two clinical entities.

Original languageEnglish (US)
Pages (from-to)383-393
Number of pages11
JournalJournal of Infectious Diseases
Volume154
Issue number3
DOIs
StatePublished - Sep 1986

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Erythema Infectiosum
Parvovirus
Serum
Disease Outbreaks
Immunoglobulin M
DNA
Parvoviridae Infections
Asymptomatic Infections
Pharynx
Infection
Electron Microscopy
Epidemiology
Research Design
Urine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Chorba, T., Coccia, P., Holman, R. C., Tattersall, P., Anderson, L. J., Sudman, J., ... Evatt, B. (1986). The role of parvovirus b19 in aplastic crisis and erythema infectiosum (Fifth disease). Journal of Infectious Diseases, 154(3), 383-393. https://doi.org/10.1093/infdis/154.3.383

The role of parvovirus b19 in aplastic crisis and erythema infectiosum (Fifth disease). / Chorba, Terence; Coccia, Peter; Holman, Robert C.; Tattersall, Peter; Anderson, Larry J.; Sudman, Jon; Young, Neal S.; Kurczynski, Elizabeth; Saarinen, Ulla M.; Moir, Robyn; Lawrence, Dale N.; Jason, Janine M.; Evatt, Bruce; Chorba, Terence; Coccia, Peter; Holman, Robert C.; Tattersall, Peter; Anderson, Larry J.; Sudman, Jon; Young, Neal S.; Kurczynski, Elizabeth; Saarinen, Ulla M.; Moir, Robyn; Lawrence, Dale N.; Jason, Janine M.; Evatt, Bruce; Chorba, Terence; Coccia, Peter; Holman, Robert C.; Tattersall, Peter; Anderson, Larry J.; Sudman, Jon; Young, Neal S.; Kurczynski, Elizabeth; Saarinen, Ulla M.; Moir, Robyn; Lawrence, Dale N.; Jason, Janine M.; Evatt, Bruce; Chorba, Terence; Coccia, Peter; Holman, Robert C.; Tattersall, Peter; Anderson, Larry J.; Sudman, Jon; Young, Neal S.; Kurczynski, Elizabeth; Saarinen, Ulla M.; Moir, Robyn; Lawrence, Dale N.; Jason, Janine M.; Evatt, Bruce; Chorba, Terence; Coccia, Peter; Holman, Robert C.; Tattersall, Peter; Anderson, Larry J.; Sudman, Jon; Young, Neal S.; Kurczynski, Elizabeth; Saarinen, Ulla M.; Moir, Robyn; Lawrence, Dale N.; Jason, Janine M.; Evatt, Bruce.

In: Journal of Infectious Diseases, Vol. 154, No. 3, 09.1986, p. 383-393.

Research output: Contribution to journalArticle

Chorba, T, Coccia, P, Holman, RC, Tattersall, P, Anderson, LJ, Sudman, J, Young, NS, Kurczynski, E, Saarinen, UM, Moir, R, Lawrence, DN, Jason, JM, Evatt, B, Chorba, T, Coccia, P, Holman, RC, Tattersall, P, Anderson, LJ, Sudman, J, Young, NS, Kurczynski, E, Saarinen, UM, Moir, R, Lawrence, DN, Jason, JM, Evatt, B, Chorba, T, Coccia, P, Holman, RC, Tattersall, P, Anderson, LJ, Sudman, J, Young, NS, Kurczynski, E, Saarinen, UM, Moir, R, Lawrence, DN, Jason, JM, Evatt, B, Chorba, T, Coccia, P, Holman, RC, Tattersall, P, Anderson, LJ, Sudman, J, Young, NS, Kurczynski, E, Saarinen, UM, Moir, R, Lawrence, DN, Jason, JM, Evatt, B, Chorba, T, Coccia, P, Holman, RC, Tattersall, P, Anderson, LJ, Sudman, J, Young, NS, Kurczynski, E, Saarinen, UM, Moir, R, Lawrence, DN, Jason, JM & Evatt, B 1986, 'The role of parvovirus b19 in aplastic crisis and erythema infectiosum (Fifth disease)', Journal of Infectious Diseases, vol. 154, no. 3, pp. 383-393. https://doi.org/10.1093/infdis/154.3.383
Chorba, Terence ; Coccia, Peter ; Holman, Robert C. ; Tattersall, Peter ; Anderson, Larry J. ; Sudman, Jon ; Young, Neal S. ; Kurczynski, Elizabeth ; Saarinen, Ulla M. ; Moir, Robyn ; Lawrence, Dale N. ; Jason, Janine M. ; Evatt, Bruce ; Chorba, Terence ; Coccia, Peter ; Holman, Robert C. ; Tattersall, Peter ; Anderson, Larry J. ; Sudman, Jon ; Young, Neal S. ; Kurczynski, Elizabeth ; Saarinen, Ulla M. ; Moir, Robyn ; Lawrence, Dale N. ; Jason, Janine M. ; Evatt, Bruce ; Chorba, Terence ; Coccia, Peter ; Holman, Robert C. ; Tattersall, Peter ; Anderson, Larry J. ; Sudman, Jon ; Young, Neal S. ; Kurczynski, Elizabeth ; Saarinen, Ulla M. ; Moir, Robyn ; Lawrence, Dale N. ; Jason, Janine M. ; Evatt, Bruce ; Chorba, Terence ; Coccia, Peter ; Holman, Robert C. ; Tattersall, Peter ; Anderson, Larry J. ; Sudman, Jon ; Young, Neal S. ; Kurczynski, Elizabeth ; Saarinen, Ulla M. ; Moir, Robyn ; Lawrence, Dale N. ; Jason, Janine M. ; Evatt, Bruce ; Chorba, Terence ; Coccia, Peter ; Holman, Robert C. ; Tattersall, Peter ; Anderson, Larry J. ; Sudman, Jon ; Young, Neal S. ; Kurczynski, Elizabeth ; Saarinen, Ulla M. ; Moir, Robyn ; Lawrence, Dale N. ; Jason, Janine M. ; Evatt, Bruce. / The role of parvovirus b19 in aplastic crisis and erythema infectiosum (Fifth disease). In: Journal of Infectious Diseases. 1986 ; Vol. 154, No. 3. pp. 383-393.
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abstract = "In 1984, simultaneous outbreaks of aplastic crisis and erythema infectiosum occurred in northeastern Ohio. Sera were analyzed from 26 patients with aplastic crisis: 24 had IgM specific for parvovirus B19, five had B19-like particles by electron microscopy, and 13 had DNA from B19; no sera from 33 controls had evidence of recent infection with B19 (P<.0001). DNA from B19 was also detected in specimens of throat gargle and urine from two patients with aplastic crisis. Sera from 36 of 51 children with erythema infectiosum had B19-specific IgM, compared with serum from one of 42 susceptible controls (P<.0001). DNA from B19 was detected in sera from only two of 51 patients who had erythema infectiosum. The secondary attack rates among susceptible contacts decreased with age (overall total, 49.6{\%}). Differential rates of asymptomatic infection were observed among black (68.8{\%}) and white (20.0{\%}) household members (P =.003). These were the first identified simultaneous outbreaks of aplastic crisis and erythema infectiosum. Their occurrence provided an opportunity to study the epidemiology and spectrum of B19 infection with geographically and temporally matched comparison groups; our results support the hypothesis that infection with parvovirus causes these two clinical entities.",
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T1 - The role of parvovirus b19 in aplastic crisis and erythema infectiosum (Fifth disease)

AU - Chorba, Terence

AU - Coccia, Peter

AU - Holman, Robert C.

AU - Tattersall, Peter

AU - Anderson, Larry J.

AU - Sudman, Jon

AU - Young, Neal S.

AU - Kurczynski, Elizabeth

AU - Saarinen, Ulla M.

AU - Moir, Robyn

AU - Lawrence, Dale N.

AU - Jason, Janine M.

AU - Evatt, Bruce

AU - Chorba, Terence

AU - Coccia, Peter

AU - Holman, Robert C.

AU - Tattersall, Peter

AU - Anderson, Larry J.

AU - Sudman, Jon

AU - Young, Neal S.

AU - Kurczynski, Elizabeth

AU - Saarinen, Ulla M.

AU - Moir, Robyn

AU - Lawrence, Dale N.

AU - Jason, Janine M.

AU - Evatt, Bruce

AU - Chorba, Terence

AU - Coccia, Peter

AU - Holman, Robert C.

AU - Tattersall, Peter

AU - Anderson, Larry J.

AU - Sudman, Jon

AU - Young, Neal S.

AU - Kurczynski, Elizabeth

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AU - Chorba, Terence

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AU - Holman, Robert C.

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AU - Anderson, Larry J.

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AU - Young, Neal S.

AU - Kurczynski, Elizabeth

AU - Saarinen, Ulla M.

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AU - Lawrence, Dale N.

AU - Jason, Janine M.

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