The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model

Jason M. Graham, Bruce P. Ayati, Sarah A. Holstein, James A. Martin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling. However, there is increasing evidence that osteocytes play important roles in the cycle of targeted bone remodeling, in serving as a significant source of RANKL to support osteoclastogenesis, and in secreting the bone formation inhibitor sclerostin. Moreover, there is also increasing interest in sclerostin, an osteocyte-secreted bone formation inhibitor, and its role in regulating local response to changes in the bone microenvironment. Here we develop a cell population model of bone remodeling that includes the role of osteocytes, sclerostin, and allows for the possibility of RANKL expression by osteocyte cell populations. We have aimed to give a simple, yet still tractable, model that remains faithful to the underlying system based on the known literature. This model extends and complements many of the existing mathematical models for bone remodeling, but can be used to explore aspects of the process of bone remodeling that were previously beyond the scope of prior modeling work. Through numerical simulations we demonstrate that our model can be used to explore theoretically many of the qualitative features of the role of osteocytes in bone biology as presented in recent literature.

Original languageEnglish (US)
Article numbere63884
JournalPloS one
Volume8
Issue number5
DOIs
StatePublished - May 22 2013

Fingerprint

Osteocytes
Bone Remodeling
Bone
Theoretical Models
mathematical models
bones
Mathematical models
Osteogenesis
Bone and Bones
bone formation
Osteoclasts
Osteoblasts
cells
Population
osteoclasts
Cells
osteoblasts
complement
Linings
Biological Sciences

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

The Role of Osteocytes in Targeted Bone Remodeling : A Mathematical Model. / Graham, Jason M.; Ayati, Bruce P.; Holstein, Sarah A.; Martin, James A.

In: PloS one, Vol. 8, No. 5, e63884, 22.05.2013.

Research output: Contribution to journalArticle

Graham, Jason M. ; Ayati, Bruce P. ; Holstein, Sarah A. ; Martin, James A. / The Role of Osteocytes in Targeted Bone Remodeling : A Mathematical Model. In: PloS one. 2013 ; Vol. 8, No. 5.
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