The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract: Friend or foe?

Reza Rahbar, Dwight T. Jones, Roger C. Nuss, David W. Roberson, Margaret A. Kenna, Trevor J. McGill, Gerald B. Healy

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objective: To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Design: Prospective study; institutional review board-approved clinical trial. Setting: Tertiary care pediatric medical center. Patients: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. Outcome: The efficacy and safety of mitomycin in the prevention of scar formation. Intervention: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Results: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Conclusion: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume128
Issue number4
DOIs
StatePublished - Jan 1 2002

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Mitomycin
Cicatrix
Pediatrics
Therapeutics
Pathologic Constriction
Choanal Atresia
Esophageal Stenosis
Research Ethics Committees
Tertiary Healthcare
Clinical Trials
Prospective Studies
Safety

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract : Friend or foe? / Rahbar, Reza; Jones, Dwight T.; Nuss, Roger C.; Roberson, David W.; Kenna, Margaret A.; McGill, Trevor J.; Healy, Gerald B.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 128, No. 4, 01.01.2002, p. 401-406.

Research output: Contribution to journalArticle

Rahbar, Reza ; Jones, Dwight T. ; Nuss, Roger C. ; Roberson, David W. ; Kenna, Margaret A. ; McGill, Trevor J. ; Healy, Gerald B. / The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract : Friend or foe?. In: Archives of Otolaryngology - Head and Neck Surgery. 2002 ; Vol. 128, No. 4. pp. 401-406.
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