Abstract
Objective: To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Design: Prospective study; institutional review board-approved clinical trial. Setting: Tertiary care pediatric medical center. Patients: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. Outcome: The efficacy and safety of mitomycin in the prevention of scar formation. Intervention: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Results: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Conclusion: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 401-406 |
| Number of pages | 6 |
| Journal | Archives of Otolaryngology - Head and Neck Surgery |
| Volume | 128 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2002 |
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ASJC Scopus subject areas
- Surgery
- Otorhinolaryngology
Cite this
The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract : Friend or foe? / Rahbar, Reza; Jones, Dwight T.; Nuss, Roger C.; Roberson, David W.; Kenna, Margaret A.; McGill, Trevor J.; Healy, Gerald B.
In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 128, No. 4, 01.01.2002, p. 401-406.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract
T2 - Friend or foe?
AU - Rahbar, Reza
AU - Jones, Dwight T.
AU - Nuss, Roger C.
AU - Roberson, David W.
AU - Kenna, Margaret A.
AU - McGill, Trevor J.
AU - Healy, Gerald B.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Objective: To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Design: Prospective study; institutional review board-approved clinical trial. Setting: Tertiary care pediatric medical center. Patients: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. Outcome: The efficacy and safety of mitomycin in the prevention of scar formation. Intervention: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Results: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Conclusion: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
AB - Objective: To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Design: Prospective study; institutional review board-approved clinical trial. Setting: Tertiary care pediatric medical center. Patients: Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. Outcome: The efficacy and safety of mitomycin in the prevention of scar formation. Intervention: All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Results: Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Conclusion: Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.
UR - http://www.scopus.com/inward/record.url?scp=0036216659&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036216659&partnerID=8YFLogxK
U2 - 10.1001/archotol.128.4.401
DO - 10.1001/archotol.128.4.401
M3 - Article
C2 - 11926915
AN - SCOPUS:0036216659
VL - 128
SP - 401
EP - 406
JO - JAMA Otolaryngology - Head and Neck Surgery
JF - JAMA Otolaryngology - Head and Neck Surgery
SN - 2168-6181
IS - 4
ER -