The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses

Ghada Soliman

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The mechanistic Target of Rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase which is a member of the PI3K related kinase (PIKK) family. mTOR emerged as a central node in cellular metabolism, cell growth, and differentiation, as well as cancer metabolism. mTOR senses the nutrients, energy, insulin, growth factors, and environmental cues and transmits signals to downstream targets to effectuate the cellular and metabolic response. Recently, mTOR was also implicated in the regulation of both the innate and adaptive immune responses. This paper will summarize the current knowledge of mTOR, as related to the immune microenvironment and immune responses.

Original languageEnglish (US)
Pages (from-to)2231-2257
Number of pages27
JournalNutrients
Volume5
Issue number6
DOIs
StatePublished - Jun 19 2013

Fingerprint

Sirolimus
phosphotransferases (kinases)
immune response
metabolism
phosphatidylinositol 3-kinase
threonine
cell differentiation
serine
growth factors
cell growth
insulin
neoplasms
energy
nutrients
Protein-Serine-Threonine Kinases
Adaptive Immunity
Phosphatidylinositol 3-Kinases
Innate Immunity
Cues
Cell Differentiation

Keywords

  • Adaptive immunity
  • B cells
  • Immunosuppression
  • Innate immunity
  • Rapamycin
  • Regulatory T cells
  • T helper
  • mTOR
  • mTORC1
  • mTORC2

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses. / Soliman, Ghada.

In: Nutrients, Vol. 5, No. 6, 19.06.2013, p. 2231-2257.

Research output: Contribution to journalReview article

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