The role of lactoferrin as an anti-inflammatory molecule

Bradley E Britigan, J. S. Serody, M. S. Cohen

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The formation of hydroxyl radical via the iron catalyzed Haber-Weiss reaction has been implicated in phagocyte-mediated microbicidal activity and inflammatory tissue injury. The fact that neutrophils contain lactoferrin and mononuclear phagocytes have the capacity to acquire exogenous iron has suggested that iron bound to lactoferrin may influence the nature of free radical products generated by these cells. Over the years the iron- lactoferrin complex has been heralded as both a promoter and inhibitor of hydroxyl radical formation. This manuscript is intended to provide an overview of work performed to date related to this controversy and to present results of a number of preliminary studies which shed further light on the role of lactoferrin in inflammation.

Original languageEnglish (US)
Pages (from-to)143-156
Number of pages14
JournalAdvances in experimental medicine and biology
Volume357
StatePublished - Dec 1 1994

Fingerprint

Lactoferrin
Anti-Inflammatory Agents
Iron
Molecules
Phagocytes
Hydroxyl Radical
Free Radicals
Neutrophils
Tissue
Inflammation
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The role of lactoferrin as an anti-inflammatory molecule. / Britigan, Bradley E; Serody, J. S.; Cohen, M. S.

In: Advances in experimental medicine and biology, Vol. 357, 01.12.1994, p. 143-156.

Research output: Contribution to journalArticle

@article{2f3ad6790c144a649c485fc1f8699484,
title = "The role of lactoferrin as an anti-inflammatory molecule",
abstract = "The formation of hydroxyl radical via the iron catalyzed Haber-Weiss reaction has been implicated in phagocyte-mediated microbicidal activity and inflammatory tissue injury. The fact that neutrophils contain lactoferrin and mononuclear phagocytes have the capacity to acquire exogenous iron has suggested that iron bound to lactoferrin may influence the nature of free radical products generated by these cells. Over the years the iron- lactoferrin complex has been heralded as both a promoter and inhibitor of hydroxyl radical formation. This manuscript is intended to provide an overview of work performed to date related to this controversy and to present results of a number of preliminary studies which shed further light on the role of lactoferrin in inflammation.",
author = "Britigan, {Bradley E} and Serody, {J. S.} and Cohen, {M. S.}",
year = "1994",
month = "12",
day = "1",
language = "English (US)",
volume = "357",
pages = "143--156",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-275X",
publisher = "Springer New York",

}

TY - JOUR

T1 - The role of lactoferrin as an anti-inflammatory molecule

AU - Britigan, Bradley E

AU - Serody, J. S.

AU - Cohen, M. S.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - The formation of hydroxyl radical via the iron catalyzed Haber-Weiss reaction has been implicated in phagocyte-mediated microbicidal activity and inflammatory tissue injury. The fact that neutrophils contain lactoferrin and mononuclear phagocytes have the capacity to acquire exogenous iron has suggested that iron bound to lactoferrin may influence the nature of free radical products generated by these cells. Over the years the iron- lactoferrin complex has been heralded as both a promoter and inhibitor of hydroxyl radical formation. This manuscript is intended to provide an overview of work performed to date related to this controversy and to present results of a number of preliminary studies which shed further light on the role of lactoferrin in inflammation.

AB - The formation of hydroxyl radical via the iron catalyzed Haber-Weiss reaction has been implicated in phagocyte-mediated microbicidal activity and inflammatory tissue injury. The fact that neutrophils contain lactoferrin and mononuclear phagocytes have the capacity to acquire exogenous iron has suggested that iron bound to lactoferrin may influence the nature of free radical products generated by these cells. Over the years the iron- lactoferrin complex has been heralded as both a promoter and inhibitor of hydroxyl radical formation. This manuscript is intended to provide an overview of work performed to date related to this controversy and to present results of a number of preliminary studies which shed further light on the role of lactoferrin in inflammation.

UR - http://www.scopus.com/inward/record.url?scp=0028658413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028658413&partnerID=8YFLogxK

M3 - Article

VL - 357

SP - 143

EP - 156

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-275X

ER -