The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

Research output: Contribution to journalReview article

92 Citations (Scopus)

Abstract

The mechanisms that control the replication state, latency versus lytic, of human herpesviruses have been under intense investigations. Here we summarize some of the recent findings that help define such mechanisms for Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8). For HHV-8, the viral regulator of transcription activation (RTA) is a key mediator of the switch from latency to lytic gene expression in infected cells. RTA is necessary and sufficient to drive HHV-8 lyric replication and the production of viral progeny. The RTA is an immediate-early gene product, it is the initial activator of expression of a multitude of viral and cellular genes that have been implicated in the replication of HHV-8 and pathogenesis of KS. Interactions of RTA with a number of viral promoters, and with a number of transcription factors or transcriptional co-activators are highlighted. Modulation of transactivation, through alternate RTA-protein, or RTA-promoter interactions, is hypothesisized to participate in the selective tissue tropism and differential pathogenesis observed in KS.

Original languageEnglish (US)
Pages (from-to)5150-5163
Number of pages14
JournalOncogene
Volume22
Issue number33 REV. ISS. 2
DOIs
StatePublished - Aug 11 2003

Fingerprint

Human Herpesvirus 8
Transcriptional Activation
Gene Expression
Immediate-Early Genes
Tropism
Viral Genes
Herpesviridae
Transcription Factors

Keywords

  • KSHV, HHV-8, herpesvirus
  • Kaposi's sarcoma
  • RTA
  • Transcriptional control

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression. / West, John T; Wood, Charles.

In: Oncogene, Vol. 22, No. 33 REV. ISS. 2, 11.08.2003, p. 5150-5163.

Research output: Contribution to journalReview article

@article{04e4fa6a044342689fff8b1a8ddedfcc,
title = "The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression",
abstract = "The mechanisms that control the replication state, latency versus lytic, of human herpesviruses have been under intense investigations. Here we summarize some of the recent findings that help define such mechanisms for Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8). For HHV-8, the viral regulator of transcription activation (RTA) is a key mediator of the switch from latency to lytic gene expression in infected cells. RTA is necessary and sufficient to drive HHV-8 lyric replication and the production of viral progeny. The RTA is an immediate-early gene product, it is the initial activator of expression of a multitude of viral and cellular genes that have been implicated in the replication of HHV-8 and pathogenesis of KS. Interactions of RTA with a number of viral promoters, and with a number of transcription factors or transcriptional co-activators are highlighted. Modulation of transactivation, through alternate RTA-protein, or RTA-promoter interactions, is hypothesisized to participate in the selective tissue tropism and differential pathogenesis observed in KS.",
keywords = "KSHV, HHV-8, herpesvirus, Kaposi's sarcoma, RTA, Transcriptional control",
author = "West, {John T} and Charles Wood",
year = "2003",
month = "8",
day = "11",
doi = "10.1038/sj.onc.1206555",
language = "English (US)",
volume = "22",
pages = "5150--5163",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "33 REV. ISS. 2",

}

TY - JOUR

T1 - The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

AU - West, John T

AU - Wood, Charles

PY - 2003/8/11

Y1 - 2003/8/11

N2 - The mechanisms that control the replication state, latency versus lytic, of human herpesviruses have been under intense investigations. Here we summarize some of the recent findings that help define such mechanisms for Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8). For HHV-8, the viral regulator of transcription activation (RTA) is a key mediator of the switch from latency to lytic gene expression in infected cells. RTA is necessary and sufficient to drive HHV-8 lyric replication and the production of viral progeny. The RTA is an immediate-early gene product, it is the initial activator of expression of a multitude of viral and cellular genes that have been implicated in the replication of HHV-8 and pathogenesis of KS. Interactions of RTA with a number of viral promoters, and with a number of transcription factors or transcriptional co-activators are highlighted. Modulation of transactivation, through alternate RTA-protein, or RTA-promoter interactions, is hypothesisized to participate in the selective tissue tropism and differential pathogenesis observed in KS.

AB - The mechanisms that control the replication state, latency versus lytic, of human herpesviruses have been under intense investigations. Here we summarize some of the recent findings that help define such mechanisms for Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8). For HHV-8, the viral regulator of transcription activation (RTA) is a key mediator of the switch from latency to lytic gene expression in infected cells. RTA is necessary and sufficient to drive HHV-8 lyric replication and the production of viral progeny. The RTA is an immediate-early gene product, it is the initial activator of expression of a multitude of viral and cellular genes that have been implicated in the replication of HHV-8 and pathogenesis of KS. Interactions of RTA with a number of viral promoters, and with a number of transcription factors or transcriptional co-activators are highlighted. Modulation of transactivation, through alternate RTA-protein, or RTA-promoter interactions, is hypothesisized to participate in the selective tissue tropism and differential pathogenesis observed in KS.

KW - KSHV, HHV-8, herpesvirus

KW - Kaposi's sarcoma

KW - RTA

KW - Transcriptional control

UR - http://www.scopus.com/inward/record.url?scp=0042467672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042467672&partnerID=8YFLogxK

U2 - 10.1038/sj.onc.1206555

DO - 10.1038/sj.onc.1206555

M3 - Review article

VL - 22

SP - 5150

EP - 5163

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 33 REV. ISS. 2

ER -