Abstract
Current evidence suggests an increasing role for inflammation as a critical link to tumor progression. The host response to a cancer shares many parallels with an infection or a wound. Thus it is not surprising that many tumors arise from areas of infection or chronic inflammation. Tumors have been described as wounds that never heal. The local production of cytokines, including chemokines not only attracts circulating immune cells, but also activates stromal cells in the surrounding microenvironment. Of particular interest are tumor-associated macrophages (TAM). The infiltration of tumors with TAM has been shown to correlate with poor prognosis in several cancers. Recent studies suggest an emerging role for TAM in the remodeling of the tumor microenvironment to support growth and metastasis and support the concept of modifying TAM's responses as novel therapeutic approaches. In this review, we will discuss our current understanding of the role of macrophages, and inflammation in the progression to malignant disease and possibilities for development of better therapeutics for the treatment and perhaps prevention of malignancies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-155 |
| Number of pages | 17 |
| Journal | Clinical Research and Regulatory Affairs |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2008 |
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Keywords
- Chemokines
- Cytokines
- Inflammation
- Malignancy
- Stromal cells
- Tumor
- Tumor-associated macrophage
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Pharmacology (medical)
Cite this
The role of inflammation in tumor progression : Targeting tumor-associated macrophages. / Varney, Michelle L.; Singh, Rakesh K.
In: Clinical Research and Regulatory Affairs, Vol. 25, No. 3, 01.09.2008, p. 139-155.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The role of inflammation in tumor progression
T2 - Targeting tumor-associated macrophages
AU - Varney, Michelle L.
AU - Singh, Rakesh K
PY - 2008/9/1
Y1 - 2008/9/1
N2 - Current evidence suggests an increasing role for inflammation as a critical link to tumor progression. The host response to a cancer shares many parallels with an infection or a wound. Thus it is not surprising that many tumors arise from areas of infection or chronic inflammation. Tumors have been described as wounds that never heal. The local production of cytokines, including chemokines not only attracts circulating immune cells, but also activates stromal cells in the surrounding microenvironment. Of particular interest are tumor-associated macrophages (TAM). The infiltration of tumors with TAM has been shown to correlate with poor prognosis in several cancers. Recent studies suggest an emerging role for TAM in the remodeling of the tumor microenvironment to support growth and metastasis and support the concept of modifying TAM's responses as novel therapeutic approaches. In this review, we will discuss our current understanding of the role of macrophages, and inflammation in the progression to malignant disease and possibilities for development of better therapeutics for the treatment and perhaps prevention of malignancies.
AB - Current evidence suggests an increasing role for inflammation as a critical link to tumor progression. The host response to a cancer shares many parallels with an infection or a wound. Thus it is not surprising that many tumors arise from areas of infection or chronic inflammation. Tumors have been described as wounds that never heal. The local production of cytokines, including chemokines not only attracts circulating immune cells, but also activates stromal cells in the surrounding microenvironment. Of particular interest are tumor-associated macrophages (TAM). The infiltration of tumors with TAM has been shown to correlate with poor prognosis in several cancers. Recent studies suggest an emerging role for TAM in the remodeling of the tumor microenvironment to support growth and metastasis and support the concept of modifying TAM's responses as novel therapeutic approaches. In this review, we will discuss our current understanding of the role of macrophages, and inflammation in the progression to malignant disease and possibilities for development of better therapeutics for the treatment and perhaps prevention of malignancies.
KW - Chemokines
KW - Cytokines
KW - Inflammation
KW - Malignancy
KW - Stromal cells
KW - Tumor
KW - Tumor-associated macrophage
UR - http://www.scopus.com/inward/record.url?scp=53149091275&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53149091275&partnerID=8YFLogxK
U2 - 10.1080/10601330802208291
DO - 10.1080/10601330802208291
M3 - Review article
AN - SCOPUS:53149091275
VL - 25
SP - 139
EP - 155
JO - Clinical Research Practices and Drug Regulatory Affairs
JF - Clinical Research Practices and Drug Regulatory Affairs
SN - 1060-1333
IS - 3
ER -