The role of electrospinning in the emerging field of nanomedicine

S. Y. Chew, Y. Wen, Yuris Dzenis, Kam W. Leong

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

The fact that in vivo the extracellular matrix (ECM) or substratum with which cells interact often includes topography at the nanoscale underscores the importance of investigating cell-substrate interactions and performing cell culture at the submicron scale. An important and exciting direction of research in nanomedicine would be to gain an understanding and exploit the cellular response to nanostructures. Electrospinning is a simple and versatile technique that can produce a macroporous scaffold comprising randomly oriented or aligned nanofibers. It can also accommodate the incorporation of drug delivery function into the fibrous scaffold. Endowed with both topographical and biochemical signals such electrospun nanofibrous scaffolds may provide an optimal microenvironment for the seeded cells. This review covers the analysis and control of the electrospinning process, and describes the types of electrospun fibers fabricated for biomedical applications such as drug delivery and tissue engineering.

Original languageEnglish (US)
Pages (from-to)4751-4770
Number of pages20
JournalCurrent Pharmaceutical Design
Volume12
Issue number36
DOIs
StatePublished - Dec 1 2006

Fingerprint

Nanomedicine
Nanofibers
Cellular Microenvironment
Nanostructures
Tissue Engineering
Cell Communication
Pharmaceutical Preparations
Extracellular Matrix
Cell Culture Techniques
Research
Direction compound

Keywords

  • Antimicrobial
  • Electrospun collagen ribbons
  • Fabrication
  • Lipophilic drugs
  • Nanofibers

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

The role of electrospinning in the emerging field of nanomedicine. / Chew, S. Y.; Wen, Y.; Dzenis, Yuris; Leong, Kam W.

In: Current Pharmaceutical Design, Vol. 12, No. 36, 01.12.2006, p. 4751-4770.

Research output: Contribution to journalArticle

Chew, S. Y. ; Wen, Y. ; Dzenis, Yuris ; Leong, Kam W. / The role of electrospinning in the emerging field of nanomedicine. In: Current Pharmaceutical Design. 2006 ; Vol. 12, No. 36. pp. 4751-4770.
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