The role of aldose reductase in the development of diabetic complications of the lens and cornea

P. F. Kador, S. Sato, M. B. Datilles

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In summary, the accumulation of polyols initiated by aldose reductase is associated with altered morphology and/or function of the lens, corneal epithelium and corneal endothelium. Prevention studies with aldose reductase inhibitors in either diabetic or galactose-fed animals indicate that these changes can be ameliorated and these results provide strong clinical implications. Although there are many similarities between these animal studies and man, long-term clinical evaluations with aldose reductase inhibitors are required to establish firmly the clinical ralationship between aldose reductase and the onset of diabetic cataracts and keratopathy.

Original languageEnglish (US)
Title of host publicationCurrent status of prevention and treatment of diabetic complications
Subtitle of host publicationproceedings of the Third International Symposium on treatment of Diabetes Mellitus. ICS821
EditorsN. Sakamoto, K.G.M.M. Alberti, N. Hotta, N. Sakamoto, K.G.M.M. Alberti, N. Hotta
PublisherElsevier Science Publishers B.V.
Pages173-180
Number of pages8
ISBN (Print)0444811605
StatePublished - Jan 1 1990
EventThe Third International Symposium on treatment of Diabetes Mellitus -
Duration: Jul 13 1988Jul 15 1988

Publication series

NameCurrent status of prevention and treatment of diabetic complications: proceedings of the Third International Symposium on treatment of Diabetes Mellitus. ICS821

Other

OtherThe Third International Symposium on treatment of Diabetes Mellitus
Period7/13/887/15/88

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kador, P. F., Sato, S., & Datilles, M. B. (1990). The role of aldose reductase in the development of diabetic complications of the lens and cornea. In N. Sakamoto, K. G. M. M. Alberti, N. Hotta, N. Sakamoto, K. G. M. M. Alberti, & N. Hotta (Eds.), Current status of prevention and treatment of diabetic complications: proceedings of the Third International Symposium on treatment of Diabetes Mellitus. ICS821 (pp. 173-180). (Current status of prevention and treatment of diabetic complications: proceedings of the Third International Symposium on treatment of Diabetes Mellitus. ICS821). Elsevier Science Publishers B.V..