The relationship of ethanol feeding to the methyl folate trap

A. J. Barak, H. C. Beckenhauer, N. Hidiroglou, M. E. Camilo, J. Selhub, D. J. Tuma

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Feeding rats a semiliquid ethanol diet for a period of four weeks produced a hepatic accumulation of the methylating agent N5-methyltetrahydrofolate (N5CH3THF). When the ethanol-containing diet was supplemented with 0.5% betaine, an agent known to promote the generation of methionine and S-adenosylmethionine (SAM) in ethanol-fed animals, the accumulation of N5CH3THF was prevented. One index that the methyl folate trap exists is the hepatic accumulation of N5CH3THF, and a second index is that the N5CH3THF accumulation can be relieved by methionine administration. Since ethanol is shown to produce N5CH3THF accumulation in this study, and since betaine (a generator of methionine and SAM) acts to eliminate this accumulation, it is suggestive that ethanol can contribute to the impairing hepatic condition referred to as the "methyl folate trap.".

Original languageEnglish (US)
Pages (from-to)495-497
Number of pages3
JournalAlcohol
Volume10
Issue number6
DOIs
StatePublished - Jan 1 1993

Fingerprint

Ethanol
Methionine
S-Adenosylmethionine
Betaine
Nutrition
Liver
Diet
Rats
Animals
5-methyltetrahydrofolate
animal

Keywords

  • Betaine
  • Ethanol
  • Methionine metabolism
  • Methyl folate trap
  • N-Methyltetrahydrofolate

ASJC Scopus subject areas

  • Health(social science)
  • Medicine(all)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Cite this

Barak, A. J., Beckenhauer, H. C., Hidiroglou, N., Camilo, M. E., Selhub, J., & Tuma, D. J. (1993). The relationship of ethanol feeding to the methyl folate trap. Alcohol, 10(6), 495-497. https://doi.org/10.1016/0741-8329(93)90072-V

The relationship of ethanol feeding to the methyl folate trap. / Barak, A. J.; Beckenhauer, H. C.; Hidiroglou, N.; Camilo, M. E.; Selhub, J.; Tuma, D. J.

In: Alcohol, Vol. 10, No. 6, 01.01.1993, p. 495-497.

Research output: Contribution to journalArticle

Barak, AJ, Beckenhauer, HC, Hidiroglou, N, Camilo, ME, Selhub, J & Tuma, DJ 1993, 'The relationship of ethanol feeding to the methyl folate trap', Alcohol, vol. 10, no. 6, pp. 495-497. https://doi.org/10.1016/0741-8329(93)90072-V
Barak AJ, Beckenhauer HC, Hidiroglou N, Camilo ME, Selhub J, Tuma DJ. The relationship of ethanol feeding to the methyl folate trap. Alcohol. 1993 Jan 1;10(6):495-497. https://doi.org/10.1016/0741-8329(93)90072-V
Barak, A. J. ; Beckenhauer, H. C. ; Hidiroglou, N. ; Camilo, M. E. ; Selhub, J. ; Tuma, D. J. / The relationship of ethanol feeding to the methyl folate trap. In: Alcohol. 1993 ; Vol. 10, No. 6. pp. 495-497.
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