The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema

Elham Hatef, Elizabeth Colantuoni, Jianmin Wang, Mohamed Ibrahim, Matthew Shulman, Fatima Adhi, Yasir Jamal Sepah, Roomasa Channa, Afsheen Khwaja, Quan Dong Nguyen, Diana V Do

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.

Original languageEnglish (US)
Pages (from-to)400-405.e2
JournalAmerican Journal of Ophthalmology
Volume152
Issue number3
DOIs
StatePublished - Jan 1 2011

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Macular Edema
Retina
Tomography
Visual Field Tests
Observational Studies
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Hatef, E., Colantuoni, E., Wang, J., Ibrahim, M., Shulman, M., Adhi, F., ... Do, D. V. (2011). The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema. American Journal of Ophthalmology, 152(3), 400-405.e2. https://doi.org/10.1016/j.ajo.2011.02.024

The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema. / Hatef, Elham; Colantuoni, Elizabeth; Wang, Jianmin; Ibrahim, Mohamed; Shulman, Matthew; Adhi, Fatima; Sepah, Yasir Jamal; Channa, Roomasa; Khwaja, Afsheen; Nguyen, Quan Dong; Do, Diana V.

In: American Journal of Ophthalmology, Vol. 152, No. 3, 01.01.2011, p. 400-405.e2.

Research output: Contribution to journalArticle

Hatef, E, Colantuoni, E, Wang, J, Ibrahim, M, Shulman, M, Adhi, F, Sepah, YJ, Channa, R, Khwaja, A, Nguyen, QD & Do, DV 2011, 'The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema', American Journal of Ophthalmology, vol. 152, no. 3, pp. 400-405.e2. https://doi.org/10.1016/j.ajo.2011.02.024
Hatef, Elham ; Colantuoni, Elizabeth ; Wang, Jianmin ; Ibrahim, Mohamed ; Shulman, Matthew ; Adhi, Fatima ; Sepah, Yasir Jamal ; Channa, Roomasa ; Khwaja, Afsheen ; Nguyen, Quan Dong ; Do, Diana V. / The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema. In: American Journal of Ophthalmology. 2011 ; Vol. 152, No. 3. pp. 400-405.e2.
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abstract = "Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4{\%}) had stable fixation (>75{\%} within central 2 degrees of point of fixation) and 1 eye (4.5{\%}) had relatively unstable fixation (<75{\%} of fixation points located within 2 degrees, >75{\%} located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2{\%}) had central (>50{\%} of fixation points within 0.5 mm of fovea), 3 eyes (13.6{\%}) pericentral (25{\%} to 50{\%} within 0.5 mm of fovea), and 4 eyes (18.2{\%}) eccentric (<25{\%} of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95{\%} confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95{\%} CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.",
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AU - Shulman, Matthew

AU - Adhi, Fatima

AU - Sepah, Yasir Jamal

AU - Channa, Roomasa

AU - Khwaja, Afsheen

AU - Nguyen, Quan Dong

AU - Do, Diana V

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AB - Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.

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