Abstract
Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 400-405.e2 |
| Journal | American journal of ophthalmology |
| Volume | 152 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2011 |
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ASJC Scopus subject areas
- Ophthalmology
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The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema. / Hatef, Elham; Colantuoni, Elizabeth; Wang, Jianmin; Ibrahim, Mohamed; Shulman, Matthew; Adhi, Fatima; Sepah, Yasir Jamal; Channa, Roomasa; Khwaja, Afsheen; Nguyen, Quan Dong; Do, Diana V.
In: American journal of ophthalmology, Vol. 152, No. 3, 09.2011, p. 400-405.e2.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship between macular sensitivity and retinal thickness in eyes with diabetic macular edema
AU - Hatef, Elham
AU - Colantuoni, Elizabeth
AU - Wang, Jianmin
AU - Ibrahim, Mohamed
AU - Shulman, Matthew
AU - Adhi, Fatima
AU - Sepah, Yasir Jamal
AU - Channa, Roomasa
AU - Khwaja, Afsheen
AU - Nguyen, Quan Dong
AU - Do, Diana V.
PY - 2011/9
Y1 - 2011/9
N2 - Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
AB - Purpose: To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME). Design: Prospective observational study. Methods: settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness. Results: Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm. Conclusions: In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
UR - http://www.scopus.com/inward/record.url?scp=80051877718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051877718&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2011.02.024
DO - 10.1016/j.ajo.2011.02.024
M3 - Article
C2 - 21696702
AN - SCOPUS:80051877718
VL - 152
SP - 400-405.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 3
ER -