The prevalence and clinical impact of obesity in adults with Marfan syndrome

Anji T. Yetman, Brian W. McCrindle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. Objective: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. Methods: Fifty outpatients (30 female) with a mean ( ± SD) age of 38 ±13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kg/m2), overweight (BMI 25 kg/m 2 to 29.9 kg/m2) or obese (BMI 30 kg/m2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. Results: A family history of aortic dissection was present in 13 (26%) patients. In 23 (46%) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4 ±7.4 kg/m2, with 18 (36%) patients having an elevated BMI. Positive smoking status was present in 15 (30%), hypertension in 13 (26%) and hyperlipidemia in 19 (38%) patients. Adverse clinical outcome was present in 27 (54%) patients. Logistic regression analysis revealed only index case (OR 44; P<0.001) and higher BMI (OR 1.2; P=0.04) to be significantly and independently associated with increased risk of adverse clinical outcome. CONCLUSIONS: Obesity is common in adults with Marfan syndrome and is associated with an increased risk of aortic complications.

Original languageEnglish (US)
Pages (from-to)e137-e139
JournalCanadian Journal of Cardiology
Volume26
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Marfan Syndrome
Body Mass Index
Obesity
Dissection
Hyperlipidemias
Outpatients
Logistic Models
Smoking
Regression Analysis
Demography
Hypertension

Keywords

  • Aorta
  • Marfan
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The prevalence and clinical impact of obesity in adults with Marfan syndrome. / Yetman, Anji T.; McCrindle, Brian W.

In: Canadian Journal of Cardiology, Vol. 26, No. 4, 04.2010, p. e137-e139.

Research output: Contribution to journalArticle

@article{3c4518c3097842afbd3a29288d60b3fa,
title = "The prevalence and clinical impact of obesity in adults with Marfan syndrome",
abstract = "Background: Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. Objective: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. Methods: Fifty outpatients (30 female) with a mean ( ± SD) age of 38 ±13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kg/m2), overweight (BMI 25 kg/m 2 to 29.9 kg/m2) or obese (BMI 30 kg/m2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. Results: A family history of aortic dissection was present in 13 (26{\%}) patients. In 23 (46{\%}) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4 ±7.4 kg/m2, with 18 (36{\%}) patients having an elevated BMI. Positive smoking status was present in 15 (30{\%}), hypertension in 13 (26{\%}) and hyperlipidemia in 19 (38{\%}) patients. Adverse clinical outcome was present in 27 (54{\%}) patients. Logistic regression analysis revealed only index case (OR 44; P<0.001) and higher BMI (OR 1.2; P=0.04) to be significantly and independently associated with increased risk of adverse clinical outcome. CONCLUSIONS: Obesity is common in adults with Marfan syndrome and is associated with an increased risk of aortic complications.",
keywords = "Aorta, Marfan, Obesity",
author = "Yetman, {Anji T.} and McCrindle, {Brian W.}",
year = "2010",
month = "4",
doi = "10.1016/S0828-282X(10)70370-6",
language = "English (US)",
volume = "26",
pages = "e137--e139",
journal = "Canadian Journal of Cardiology",
issn = "0828-282X",
publisher = "Pulsus Group Inc.",
number = "4",

}

TY - JOUR

T1 - The prevalence and clinical impact of obesity in adults with Marfan syndrome

AU - Yetman, Anji T.

AU - McCrindle, Brian W.

PY - 2010/4

Y1 - 2010/4

N2 - Background: Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. Objective: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. Methods: Fifty outpatients (30 female) with a mean ( ± SD) age of 38 ±13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kg/m2), overweight (BMI 25 kg/m 2 to 29.9 kg/m2) or obese (BMI 30 kg/m2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. Results: A family history of aortic dissection was present in 13 (26%) patients. In 23 (46%) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4 ±7.4 kg/m2, with 18 (36%) patients having an elevated BMI. Positive smoking status was present in 15 (30%), hypertension in 13 (26%) and hyperlipidemia in 19 (38%) patients. Adverse clinical outcome was present in 27 (54%) patients. Logistic regression analysis revealed only index case (OR 44; P<0.001) and higher BMI (OR 1.2; P=0.04) to be significantly and independently associated with increased risk of adverse clinical outcome. CONCLUSIONS: Obesity is common in adults with Marfan syndrome and is associated with an increased risk of aortic complications.

AB - Background: Patients with Marfan syndrome characteristically have an asthenic body habitus and are considered to be exempt from the obesity epidemic. Objective: To examine the prevalence and clinical impact of obesity in a cohort of adults with Marfan syndrome. Methods: Fifty outpatients (30 female) with a mean ( ± SD) age of 38 ±13 years were studied. Demographic variables including previously identified risk factors for aortic dissection were recorded. Body mass index (BMI) was determined and patients were classified as normal (BMI less than 25 kg/m2), overweight (BMI 25 kg/m 2 to 29.9 kg/m2) or obese (BMI 30 kg/m2 or greater). Other cardiovascular risk factors were examined. An adverse clinical outcome was defined as either the attainment of surgical criteria for aortic root replacement or the presence of aortic dissection. Results: A family history of aortic dissection was present in 13 (26%) patients. In 23 (46%) patients, there was no known family history of Marfan syndrome. Mean BMI was 25.4 ±7.4 kg/m2, with 18 (36%) patients having an elevated BMI. Positive smoking status was present in 15 (30%), hypertension in 13 (26%) and hyperlipidemia in 19 (38%) patients. Adverse clinical outcome was present in 27 (54%) patients. Logistic regression analysis revealed only index case (OR 44; P<0.001) and higher BMI (OR 1.2; P=0.04) to be significantly and independently associated with increased risk of adverse clinical outcome. CONCLUSIONS: Obesity is common in adults with Marfan syndrome and is associated with an increased risk of aortic complications.

KW - Aorta

KW - Marfan

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=77950620248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950620248&partnerID=8YFLogxK

U2 - 10.1016/S0828-282X(10)70370-6

DO - 10.1016/S0828-282X(10)70370-6

M3 - Article

C2 - 20386774

AN - SCOPUS:77950620248

VL - 26

SP - e137-e139

JO - Canadian Journal of Cardiology

JF - Canadian Journal of Cardiology

SN - 0828-282X

IS - 4

ER -