The presence of icaADBC is detrimental to the colonization of human skin by Staphylococcus epidermidis

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Previous studies have demonstrated that Staphylococcus epidermidis isolates colonizing the skin of healthy humans do not typically encode icaADBC, the genes responsible for the production of polysaccharide intercellular adhesin or biofilms. It was therefore hypothesized that the presence of icaADBC was deleterious to the successful colonization of human skin by S. epidermidis. Using a human skin competition model, it was determined that the strong biofilm-producing S. epidermidis strain 1457 was outcompeted at 1, 3, and 10 days by an isogenic icaADBC mutant (1457 ica::dhfr), suggesting a fitness cost for carriage of icaADBC.

Original languageEnglish (US)
Pages (from-to)6155-6157
Number of pages3
JournalApplied and environmental microbiology
Volume74
Issue number19
DOIs
StatePublished - Oct 1 2008

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Staphylococcus epidermidis
skin (animal)
skin
colonization
Biofilms
biofilm
Skin
adhesins
polysaccharide
fitness
polysaccharides
Costs and Cost Analysis
mutants
gene
cost
Genes
genes

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

Cite this

The presence of icaADBC is detrimental to the colonization of human skin by Staphylococcus epidermidis. / Rogers, K. L.; Rupp, Mark Edmund; Fey, Paul D.

In: Applied and environmental microbiology, Vol. 74, No. 19, 01.10.2008, p. 6155-6157.

Research output: Contribution to journalArticle

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