The practicality of mesoporous silica nanoparticles as drug delivery devices and progress toward this goal

Robert Roggers, Shrey Kanvinde, Suthida Boonsith, David Oupický

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Mesoporous silica nanoparticles (MSNs) have been proposed as drug delivery devices for approximately 15 years. The history of in vitro studies has been promising, demonstrating that MSNs have the capability for stimulus-responsive controlled release, good cellular uptake, cell specific targeting, and the ability to carry a variety of cargoes from hydrophobic drug molecules to imaging agents. However, the translation of the in vitro findings to in vivo conditions has been slow. Herein, we review the current state-of-the-art in the use of MSN for systemic drug delivery in vivo and provide critical insight into the future of MSNs as systemic drug delivery devices and directions that should be undertaken to improve their practicality.

Original languageEnglish (US)
Pages (from-to)1163-1171
Number of pages9
JournalAAPS PharmSciTech
Volume15
Issue number5
DOIs
StatePublished - Oct 1 2014

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Keywords

  • drug delivery
  • mesoporous silica
  • nanoparticles

ASJC Scopus subject areas

  • Pharmaceutical Science

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