The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons

Mahmoud Hasan, Shahrzad Latifi, Cyril J.F. Kahn, Ali Tamayol, Rouhollah Habibey, Elodie Passeri, Michel Linder, Elmira Arab-Tehrany

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

Original languageEnglish (US)
Article number218
JournalMarine Drugs
Volume16
Issue number7
DOIs
StatePublished - Jul 2018

Fingerprint

Curcumin
Salmon
Neurons
Solubility
Biological Availability
Lecithins
Insurance Benefits
Liposomes
Apoptosis
Water

Keywords

  • Curcumin
  • Nanoliposome
  • Polar lipid
  • Primary cortical neurons
  • Transfer

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Hasan, M., Latifi, S., Kahn, C. J. F., Tamayol, A., Habibey, R., Passeri, E., ... Arab-Tehrany, E. (2018). The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons. Marine Drugs, 16(7), [218]. https://doi.org/10.3390/md16070218

The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons. / Hasan, Mahmoud; Latifi, Shahrzad; Kahn, Cyril J.F.; Tamayol, Ali; Habibey, Rouhollah; Passeri, Elodie; Linder, Michel; Arab-Tehrany, Elmira.

In: Marine Drugs, Vol. 16, No. 7, 218, 07.2018.

Research output: Contribution to journalArticle

Hasan, M, Latifi, S, Kahn, CJF, Tamayol, A, Habibey, R, Passeri, E, Linder, M & Arab-Tehrany, E 2018, 'The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons', Marine Drugs, vol. 16, no. 7, 218. https://doi.org/10.3390/md16070218
Hasan, Mahmoud ; Latifi, Shahrzad ; Kahn, Cyril J.F. ; Tamayol, Ali ; Habibey, Rouhollah ; Passeri, Elodie ; Linder, Michel ; Arab-Tehrany, Elmira. / The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons. In: Marine Drugs. 2018 ; Vol. 16, No. 7.
@article{f9944d3f3c8a43be85e84c9bbde25d3b,
title = "The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons",
abstract = "Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.",
keywords = "Curcumin, Nanoliposome, Polar lipid, Primary cortical neurons, Transfer",
author = "Mahmoud Hasan and Shahrzad Latifi and Kahn, {Cyril J.F.} and Ali Tamayol and Rouhollah Habibey and Elodie Passeri and Michel Linder and Elmira Arab-Tehrany",
year = "2018",
month = "7",
doi = "10.3390/md16070218",
language = "English (US)",
volume = "16",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

TY - JOUR

T1 - The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons

AU - Hasan, Mahmoud

AU - Latifi, Shahrzad

AU - Kahn, Cyril J.F.

AU - Tamayol, Ali

AU - Habibey, Rouhollah

AU - Passeri, Elodie

AU - Linder, Michel

AU - Arab-Tehrany, Elmira

PY - 2018/7

Y1 - 2018/7

N2 - Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

AB - Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

KW - Curcumin

KW - Nanoliposome

KW - Polar lipid

KW - Primary cortical neurons

KW - Transfer

UR - http://www.scopus.com/inward/record.url?scp=85051645717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051645717&partnerID=8YFLogxK

U2 - 10.3390/md16070218

DO - 10.3390/md16070218

M3 - Article

C2 - 29941790

AN - SCOPUS:85051645717

VL - 16

JO - Marine Drugs

JF - Marine Drugs

SN - 1660-3397

IS - 7

M1 - 218

ER -