The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons

Mahmoud Hasan, Shahrzad Latifi, Cyril J.F. Kahn, Ali Tamayol, Rouhollah Habibey, Elodie Passeri, Michel Linder, Elmira Arab-Tehrany

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6 Scopus citations

Abstract

Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

Original languageEnglish (US)
Article number218
JournalMarine Drugs
Volume16
Issue number7
DOIs
StatePublished - Jul 2018

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Keywords

  • Curcumin
  • Nanoliposome
  • Polar lipid
  • Primary cortical neurons
  • Transfer

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Hasan, M., Latifi, S., Kahn, C. J. F., Tamayol, A., Habibey, R., Passeri, E., Linder, M., & Arab-Tehrany, E. (2018). The positive role of curcumin-loaded Salmon nanoliposomes on the culture of primary cortical neurons. Marine Drugs, 16(7), [218]. https://doi.org/10.3390/md16070218