The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells.

Huanfa Yi, Y. Zhen, Lingling Jiang, Jialin Zheng, Yong Zhao

Research output: Contribution to journalReview article

103 Citations (Scopus)

Abstract

The homeostasis of the immune system depends on the balance between the immune response to an invaded pathogen and the immune tolerance to self antigens. Both central and peripheral tolerances are important mechanisms for the induction and maintenance of T cell tolerance. Recently, much attention has been paid to regulatory T cells (Treg), which play a significant role in maintaining peripheral immune tolerance. So far, there has been no satisfactory advance regarding the surface markers of Treg cells, as none is unique for Treg cells. In this review, we summarize some important molecules expressed in naturally occurring CD4+CD25+ Treg cells (nTreg), including forkhead/winged-helix family transcriptional repressor p3 (Foxp3), the tumor necrosis factor receptor (TNFR) family, CD28/CTLA4 molecules, chemokine receptors, Toll-like receptors (TLRs), membrane-bound TGF-beta and other molecules, such as neuropilin-1, lymphocyte activation gene-3 (LAG)-3 and granzyme. This review provides a collective view on current studies of nTreg cell activation and development related to the expression of molecules and cell phenotype markers, which is important for elucidation of nTreg cell origin, development and function.

Original languageEnglish (US)
Pages (from-to)189-195
Number of pages7
JournalCellular & molecular immunology
Volume3
Issue number3
StatePublished - Jun 2006

Fingerprint

Regulatory T-Lymphocytes
Peripheral Tolerance
T-Lymphocytes
Immune Tolerance
Central Tolerance
Neuropilin-1
Granzymes
Tumor Necrosis Factor Receptors
Chemokine Receptors
Toll-Like Receptors
Autoantigens
Lymphocyte Activation
Transforming Growth Factor beta
Immune System
Homeostasis
Maintenance
Phenotype
Membranes
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells. / Yi, Huanfa; Zhen, Y.; Jiang, Lingling; Zheng, Jialin; Zhao, Yong.

In: Cellular & molecular immunology, Vol. 3, No. 3, 06.2006, p. 189-195.

Research output: Contribution to journalReview article

Yi, Huanfa ; Zhen, Y. ; Jiang, Lingling ; Zheng, Jialin ; Zhao, Yong. / The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells. In: Cellular & molecular immunology. 2006 ; Vol. 3, No. 3. pp. 189-195.
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