The Pharmacology and Clinical Use of Methotrexate

Jacques Jolivet, Kenneth H Cowan, Gregory A. Curt, Neil J. Clendeninn, Bruce A. Chabner

Research output: Contribution to journalReview article

598 Citations (Scopus)

Abstract

METHOTREXATE, the most widely used antimetabolite in cancer chemotherapy, has an essential role in the treatment of such diverse diseases as acute lymphocytic leukemia, non-Hodgkin's lymphoma, osteosarcoma, choriocarcinoma, head and neck cancer, and breast cancer.1 It has also become an important therapeutic alternative in the treatment of severe psoriasis2 and in the suppression of graft-versus-host disease after bone-marrow transplantation,3 as well as in the experimental treatment of various rheumatic diseases after primary therapy has failed.4 Through pharmacologic research we have gained an understanding of the basic steps in the action of methotrexate, including its transport across cell membranes, its intracellular.

Original languageEnglish (US)
Pages (from-to)1094-1104
Number of pages11
JournalNew England Journal of Medicine
Volume309
Issue number18
DOIs
StatePublished - Nov 3 1983

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Clinical Pharmacology
Methotrexate
Therapeutics
Antimetabolites
Choriocarcinoma
Graft vs Host Disease
Osteosarcoma
Head and Neck Neoplasms
Rheumatic Diseases
Bone Marrow Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-Hodgkin's Lymphoma
Cell Membrane
Breast Neoplasms
Drug Therapy
Research
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jolivet, J., Cowan, K. H., Curt, G. A., Clendeninn, N. J., & Chabner, B. A. (1983). The Pharmacology and Clinical Use of Methotrexate. New England Journal of Medicine, 309(18), 1094-1104. https://doi.org/10.1056/NEJM198311033091805

The Pharmacology and Clinical Use of Methotrexate. / Jolivet, Jacques; Cowan, Kenneth H; Curt, Gregory A.; Clendeninn, Neil J.; Chabner, Bruce A.

In: New England Journal of Medicine, Vol. 309, No. 18, 03.11.1983, p. 1094-1104.

Research output: Contribution to journalReview article

Jolivet, J, Cowan, KH, Curt, GA, Clendeninn, NJ & Chabner, BA 1983, 'The Pharmacology and Clinical Use of Methotrexate', New England Journal of Medicine, vol. 309, no. 18, pp. 1094-1104. https://doi.org/10.1056/NEJM198311033091805
Jolivet, Jacques ; Cowan, Kenneth H ; Curt, Gregory A. ; Clendeninn, Neil J. ; Chabner, Bruce A. / The Pharmacology and Clinical Use of Methotrexate. In: New England Journal of Medicine. 1983 ; Vol. 309, No. 18. pp. 1094-1104.
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